CE IVD certificate

Free DNA Fetal Kit® RhD


Product family:

Product family:
Hematology and blood bank



The determination of fetal RHD genotyping in maternal blood allows:

  • Establish if a negative RhD pregnant woman requires the immunoprophylaxis vaccine administration.
  • The management of a risky pregnancy, in RhD negative pregnants with anti-D, to determine if the fetus is at risk of Haemolytic Disease of the fetus and Newborn (EHRN).
  • Avoid the unnecessary administration of anti-D immunoglobulin, in case of negative fetal RhD genotype, thus avoiding its associated risk.
  • Increase the availability of anti-D immunoglobulin for use after potential sensitization events (PSE) in pregnancies where the result of Non-invasive Prenatal Diagnosis (NIPD) for the fetal RhD genotype is positive.
  • Avoid unnecessary painful injections for women in whom Non-Invasive Prenatal Diagnosis for the fetal RhD genotype is negative.
  • Reduce the number of prenatal appointments for prophylactic anti-D treatment and the amount of anti-D immunoglobulin used.
  • Reduce the anxiety associated with potential sensitization events for RhD negative women when the outcome of NIPD for the fetal RhD genotype is negative.
  • Provide information to allow RhD negative women to make an informed decision about whether or not they should receive anti-D immunoglobulin treatment based on the outcome of the fetal genotype.

Non-invasive test performed from maternal plasma

Collection in EDTA tubes

Samples collected after 11 weeks of gestation

Based on Real Time PCR technique (RT-PCR)

Amplification of three exons of the RHD gene (exons 5, 7 and 10)

RT-PCR Instruments previously validated:

  • Dx RealTimeSystem (BioRad)
  • LightCycler480 (Roche)
  • LightCycler2 (Roche)

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