Prolaris®

CatalogOncologySolid Tumor
MCM5 is a group of MCM proteins that is produced in cells during replication and is a novel cancer biomarker.
Proliferating cells express MCM5 protein at a high level, whilst quiescent terminally differentiated cells, and senescent cells lack MCM5 expression.
In contrast, both non-invasive and invasive urothelial carcinomas express MCM5 in all layers of the urothelium including superficial epithelial cells. This results in the exfoliation of MCM5-expressing tumour cells into the urine. Therefore the presence of MCM5 in the urine sediment is an excellent indicator of the presence of a urological tumour.
ADXBLADDER by Arquer Diagnostics delivers a simple, rapid and highly reliable diagnosis of bladder cancer from urine.
This ELISA kit has been designed for the detection of MCM5 protein in human urine for the diagnostic of bladder cancer in patients who have hematuria and symptoms in the lower urinary tract with suspected malignancy.
The negative predictive value of the Arquer MCM5 ELISA test is 98% (based on a prevalence of 8.38%).
Comparisons to alternative urine tests demonstrate that the Arquer's MCM5 ELISA kit has superior sensitivity to both NMP22 and urine cytology, with the MCM5 ELISA identifying all of the cases detected by these urine based methods.
Public Documentation
Related products
2021 © Diagnóstica Longwood SL
This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.
Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings.
If you disable this cookie, we will not be able to save your preferences. This means that every time you visit this website you will need to enable or disable cookies again.
This website uses Google Analytics to collect anonymous information such as the number of visitors to the site, and the most popular pages.
Keeping this cookie enabled helps us to improve our website.
Please enable Strictly Necessary Cookies first so that we can save your preferences!
Más información sobre nuestra política de cookies