{"id":26780,"date":"2025-10-06T09:16:48","date_gmt":"2025-10-06T09:16:48","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=26780"},"modified":"2026-03-18T13:37:55","modified_gmt":"2026-03-18T13:37:55","slug":"twist-precision-exome-dx","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/twist-precision-exome-dx\/","title":{"rendered":"Twist Precision Exome Dx"},"content":{"rendered":"\n<!-- Bloque de Estilos Scoped (Aislados, Blindados y Escalados a 14px) -->\n<style>\n    \/* Importaci\u00f3n de fuentes corporativas *\/\n    @import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:wght@400;700&family=Raleway:wght@300;400;500;600;700&display=swap');\n\n    \/* Contenedor Principal Aislado *\/\n    .dlw-prod-wrapper {\n        font-family: 'Raleway', sans-serif !important;\n        color: #000000 !important;\n        line-height: 1.6 !important;\n        background-color: transparent !important;\n    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reagents. <strong>The result: achieving the best coverage uniformity on the market and superior quality data for clinical environments.<\/strong><\/p>\n    <\/div>\n\n    <!-- Descripci\u00f3n Detallada -->\n    <h2>Detailed Description<\/h2>\n\n    <h3>Operating Principle<\/h3>\n    <p>The system combines a streamlined library preparation, based on single-tube enzymatic fragmentation, with selective enrichment of regions of interest using high-precision capture probes. The panel design ensures a high on-target rate and uniform coverage, generating highly complex libraries and homogeneous enrichment of the regions of interest.<\/p>\n    \n    <!-- Imagen 2 -->\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/03\/unnamed-2.webp\" alt=\"Twist Exome Workflow\" class=\"dlw-prod-img\" title=\"\">\n\n    <h3>Clinical Applications<\/h3>\n    <p>Whole exome sequencing (WES) is currently an essential tool in clinical practice for identifying genomic alterations with diagnostic and\/or therapeutic relevance. Compared to whole genome sequencing, it offers lower cost and optimal coverage of the coding regions of the human genome, facilitating more precise diagnoses and informed medical decision-making.<\/p>\n\n    <h3>Benefits<\/h3>\n    <p>The panel captures 37.7 Mb of the human genome and includes over 97% of the reference bases such as CCDS, RefSeq, Gencode, and Ensembl v101. Additionally, it covers clinically relevant regions, such as pathogenic or likely pathogenic intronic variants reported in ClinVar, and incorporates the mitochondrial genome.<\/p>\n    <p>This translates into highly complex libraries, uniform enrichment, and robust performance that meets the highest IVDR standards.<\/p>\n\n    <h3>Technology Used<\/h3>\n    <p>The kits include individual library preparation reagents by enzymatic fragmentation, using Unique Dual Indices; and the necessary reagents for target enrichment by capture, including the human mitochondrial genome.<\/p>\n    <p>The IVDR marking guarantees reproducible results, validated quality, and tested performance.<\/p>\n\n    <h3>Intended Audience\/User<\/h3>\n    <p>Molecular diagnostic laboratories working with human genomic DNA samples for whole exome applications, in in vitro diagnostic environments.<\/p>\n\n    <h3>Additional Considerations<\/h3>\n    <p>To facilitate the integration of IVDR workflows in laboratories, Twist has partnered with Platomics and its PlatoX\u00ae IVD Assistant platform, although the end-user must perform additional validation when integrating the products into diagnostic applications.<\/p>\n\n    <!-- Aspectos Clave -->\n    <h2>Key Features<\/h2>\n    \n    <div class=\"dlw-check-list\">\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>98% of on-target bases with \u226530x coverage.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>>95% of regions covered at \u226550x and 98% at \u226530x.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>On-target percentage: ~85%.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Probes covering 37.7 Mb of the human genome.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>>97% coverage in CCDS, RefSeq, Gencode, and Ensembl v101.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Uniformity rate close to 1 (Fold-80 base penalty metric), which translates to fewer wasted reads.<\/span>\n        <\/div>\n    <\/div>\n\n    <!-- Imagen 3 -->\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/03\/Twist-exome-funcionamiento.webp\" alt=\"Twist Exome Funcionamiento\" class=\"dlw-prod-img\" title=\"\">\n\n    <!-- Detalles de Presentaci\u00f3n -->\n    <h2>Presentation Details<\/h2>\n    <p>Available in two formats:<\/p>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\"><strong>By components:<\/strong> Twist Precision Prep and Enrichment Dx Kit and Twist Precision Exome Dx Panel.<\/span>\n        <span class=\"dlw-list-item\"><strong>As a complete solution:<\/strong> Twist Exome Dx Kit.<\/span>\n    <\/div>\n\n    <h3>Included components (depending on kit):<\/h3>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\"><strong>Twist Exome Dx Kit (complete solution):<\/strong> fragmentation and library preparation reagents + target enrichment + exome probes.<\/span>\n        <span class=\"dlw-list-item\"><strong>Twist Precision Prep and Enrichment Dx Kit:<\/strong> reagents for enzymatic fragmentation, library preparation, and target enrichment.<\/span>\n        <span class=\"dlw-list-item\"><strong>Twist Precision Exome Dx Panel:<\/strong> targeted capture probes for exome enrichment.<\/span>\n    <\/div>\n\n    <!-- Referencias (Acordeones Desplegables) -->\n    <h2>References<\/h2>\n\n    <details class=\"dlw-accordion\">\n        <summary class=\"dlw-accordion-header\">Twist Precision Exome Dx Kits<\/summary>\n        <div class=\"dlw-accordion-content\">\n            <table class=\"dlw-table\">\n                <tbody>\n                    <tr>\n                        <td width=\"30%\" class=\"dlw-ref-code\">104984<\/td>\n                        <td width=\"70%\">16\u00d72 samples<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">104985<\/td>\n                        <td>96\u00d712 samples (Plate A)<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">104986<\/td>\n                        <td>96\u00d712 samples (Plate B)<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">104987<\/td>\n                        <td>96\u00d712 samples (Plate C)<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">104988<\/td>\n                        <td>96\u00d712 samples (Plate D)<\/td>\n                    <\/tr>\n                <\/tbody>\n            <\/table>\n        <\/div>\n    <\/details>\n\n    <details class=\"dlw-accordion\">\n        <summary class=\"dlw-accordion-header\">Twist Precision Prep and Enrichment Dx Kits<\/summary>\n        <div class=\"dlw-accordion-content\">\n            <table class=\"dlw-table\">\n                <tbody>\n                    <tr>\n                        <td width=\"30%\" class=\"dlw-ref-code\">107626<\/td>\n                        <td width=\"70%\">16\u00d72 reactions<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">107627<\/td>\n                        <td>96\u00d712 reactions (Plate A)<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">107628<\/td>\n                        <td>96\u00d712 reactions (Plate B)<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">107629<\/td>\n                        <td>96\u00d712 reactions (Plate C)<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">107630<\/td>\n                        <td>96\u00d712 reactions (Plate D)<\/td>\n                    <\/tr>\n                <\/tbody>\n            <\/table>\n        <\/div>\n    <\/details>\n\n    <details class=\"dlw-accordion\">\n        <summary class=\"dlw-accordion-header\">Twist Precision Exome Dx Panels<\/summary>\n        <div class=\"dlw-accordion-content\">\n            <table class=\"dlw-table\">\n                <tbody>\n                    <tr>\n                        <td width=\"30%\" class=\"dlw-ref-code\">107619<\/td>\n                        <td width=\"70%\">2 reactions<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">107620<\/td>\n                        <td>12 reactions<\/td>\n                    <\/tr>\n                <\/tbody>\n            <\/table>\n        <\/div>\n    <\/details>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>IVDR workflow for whole exome sequencing (WES) that integrates Twist&#8217;s exclusive double-stranded DNA (dsDNA) probe technology with its library preparation and targeted capture reagents. The result: achieving the best coverage uniformity on the market and superior quality data for clinical environments. Detailed Description Operating Principle The system combines a streamlined library preparation, based on single-tube [&hellip;]<\/p>\n","protected":false},"featured_media":26772,"template":"","tecnologias":[36],"marcas":[242],"familias":[283,297,425],"class_list":["post-26780","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-next-generation-sequencing-ngs","marcas-twist-bioscience-en","familias-molecular-genetics","familias-exomes","familias-hereditary_and_or_rare_diseases"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/26780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":3,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/26780\/revisions"}],"predecessor-version":[{"id":26797,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/26780\/revisions\/26797"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/26772"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=26780"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=26780"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=26780"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=26780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}