{"id":26834,"date":"2026-03-19T12:32:03","date_gmt":"2026-03-19T12:32:03","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=26834"},"modified":"2026-03-19T12:46:20","modified_gmt":"2026-03-19T12:46:20","slug":"cosmx-spatial-molecular-imager-smi","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/cosmx-spatial-molecular-imager-smi\/","title":{"rendered":"CosMx Spatial Molecular Imager (SMI)"},"content":{"rendered":"\n<!-- Bloque de Estilos Scoped (Aislados, Blindados y Escalados a 14px) -->\n<style>\n    \/* Importaci\u00f3n de fuentes corporativas *\/\n    @import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:ital,wght@0,400;0,700;1,400&family=Raleway:wght@300;400;500;600;700&display=swap');\n\n    \/* Contenedor Principal Aislado *\/\n    .dlw-prod-wrapper {\n        font-family: 'Raleway', sans-serif !important;\n        color: #000000 !important;\n        line-height: 1.6 !important;\n        background-color: transparent !important;\n        padding: 0 !important;\n        max-width: 100% !important;\n        text-align: left !important;\n        display: block !important;\n        font-size: 14px !important; \/* ANCLAJE: Ignora el tama\u00f1o root defectuoso de Bricks *\/\n    }\n\n    \/* Variables CSS locales *\/\n    .dlw-prod-wrapper {\n        --dlw-blue-dark: #003a70;\n        --dlw-blue-cyan: #00a1e0;\n        --dlw-light-bg: #f9fbfd;\n        --dlw-grey-bg: #f4f6f8;\n        --dlw-border: #e1e8f0;\n    }\n\n    \/* Titulares H2 *\/\n    .dlw-prod-wrapper h2 {\n        font-family: 'Playfair Display', serif !important;\n        color: var(--dlw-blue-dark) !important;\n        margin-top: 2em !important;\n        margin-bottom: 0.8em !important;\n        font-size: 1.8em !important;\n        font-weight: 700 !important;\n        border-bottom: 2px solid var(--dlw-border) !important;\n        padding-bottom: 10px !important;\n        display: block !important;\n    }\n\n    \/* Titulares H3 *\/\n    .dlw-prod-wrapper h3 {\n        font-family: 'Playfair Display', serif !important;\n        color: var(--dlw-blue-cyan) !important;\n        margin-top: 1.5em !important;\n        margin-bottom: 0.5em !important;\n        font-size: 1.4em !important;\n        font-weight: 700 !important;\n        display: block !important;\n    }\n\n    \/* P\u00e1rrafos est\u00e1ndar *\/\n    .dlw-prod-wrapper p {\n        font-weight: 400 !important;\n        margin-bottom: 1.2em !important;\n        text-align: justify !important;\n        font-size: 1.25em !important; \/* 1.25em sobre 14px = 17.5px reales *\/\n        color: #333333 !important;\n    }\n\n    \/* Negritas corporativas *\/\n    .dlw-prod-wrapper strong {\n        color: var(--dlw-blue-dark) !important;\n        font-weight: 700 !important;\n    }\n\n    \/* Lead \/ Descripci\u00f3n Corta (Caja Azul Corporativa) *\/\n    .dlw-lead-box {\n        background-color: var(--dlw-blue-dark) !important;\n        color: #ffffff !important;\n        padding: 2.5em 3em !important;\n        margin-bottom: 3em !important;\n        border-radius: 8px !important;\n        box-shadow: 0 6px 25px rgba(0, 58, 112, 0.2) !important;\n    }\n\n    .dlw-lead-box p {\n        color: #ffffff !important;\n        font-size: 1.25em !important;\n        font-weight: 400 !important;\n        margin-bottom: 1em !important;\n        text-align: left !important;\n    }\n    \n    .dlw-lead-box p:last-child {\n        margin-bottom: 0 !important;\n    }\n\n    .dlw-lead-box strong {\n        color: var(--dlw-blue-cyan) !important;\n    }\n\n    \/* Im\u00e1genes con Efecto Hover Zoom (Sin sombra, centradas forzosamente) *\/\n    .dlw-news-img-wrapper {\n        text-align: center !important;\n        width: 100% !important;\n        display: block !important;\n        margin: 3em 0 !important;\n    }\n\n    .dlw-news-img {\n        width: 100% !important;\n        height: auto !important;\n        display: inline-block !important; \/* Forzar acatamiento del text-align: center del padre *\/\n        margin: 0 auto !important;\n        max-width: 80% !important;\n        border-radius: 6px !important;\n        box-shadow: none !important; \/* Sin sombra *\/\n        transition: transform 0.4s cubic-bezier(0.165, 0.84, 0.44, 1) !important;\n    }\n\n    .dlw-news-img:hover {\n        transform: scale(1.04) !important;\n        cursor: zoom-in !important;\n    }\n\n    \/* Listas est\u00e1ndar (Puntos) *\/\n    .dlw-list {\n        display: flex !important;\n        flex-direction: column !important;\n        margin-bottom: 2em !important;\n        padding-left: 0 !important;\n    }\n\n    .dlw-list-item {\n        position: relative !important;\n        padding-left: 1.5em !important;\n        margin-bottom: 0.8em !important;\n        text-align: left !important;\n        font-size: 1.25em !important;\n        color: #333333 !important;\n        display: block !important;\n    }\n\n    .dlw-list-item::before {\n        content: \"\u2022\" !important;\n        position: absolute !important;\n        left: 0 !important;\n        color: var(--dlw-blue-cyan) !important;\n        font-weight: bold !important;\n        font-size: 1.2em !important;\n        top: -2px !important;\n    }\n\n    \/* Listas Check (Aspectos Clave) *\/\n    .dlw-check-list {\n        display: grid !important;\n        grid-template-columns: 1fr 1fr !important;\n        gap: 1.5em 2em !important;\n        margin: 2em 0 !important;\n        background-color: var(--dlw-light-bg) !important;\n        padding: 2.5em !important;\n        border-radius: 8px !important;\n        border-left: 6px solid var(--dlw-blue-cyan) !important;\n    }\n\n    .dlw-check-item {\n        display: flex !important;\n        align-items: flex-start !important;\n        gap: 12px !important;\n        font-size: 1.2em !important;\n        color: #333333 !important;\n        line-height: 1.4 !important;\n    }\n\n    .dlw-check-icon {\n        width: 24px !important;\n        height: 24px !important;\n        min-width: 24px !important;\n        fill: var(--dlw-blue-cyan) !important;\n        margin-top: 2px !important;\n    }\n\n    \/* Grid de Paneles (Placeholders T\u00e1cticos) *\/\n    .dlw-panels-grid {\n        display: grid !important;\n        grid-template-columns: 1fr 1fr !important; \/* Forzado estricto a 2 columnas (Grid 2x2) *\/\n        gap: 20px !important;\n        margin: 2.5em 0 !important;\n    }\n\n    .dlw-panel-card {\n        background-color: #ffffff !important;\n        border: 1px solid var(--dlw-border) !important;\n        border-radius: 8px !important;\n        padding: 2em 1.5em !important;\n        text-align: center !important;\n        text-decoration: none !important;\n        transition: all 0.3s ease !important;\n        box-shadow: 0 4px 15px rgba(0, 0, 0, 0.03) !important;\n        display: flex !important;\n        flex-direction: column !important;\n        align-items: center !important;\n        justify-content: center !important;\n    }\n\n    .dlw-panel-card:hover {\n        border-color: var(--dlw-blue-cyan) !important;\n        box-shadow: 0 6px 20px rgba(0, 161, 224, 0.15) !important;\n        transform: translateY(-3px) !important;\n    }\n\n    \/* CSS de im\u00e1genes reales para el grid *\/\n    .dlw-panel-img {\n        width: 120px !important; \n        height: 120px !important; \n        margin-bottom: 15px !important;\n        object-fit: contain !important;\n        transition: transform 0.3s ease !important;\n    }\n\n    .dlw-panel-card:hover .dlw-panel-img {\n        transform: scale(1.1) !important;\n    }\n\n    .dlw-panel-title {\n        font-family: 'Raleway', sans-serif !important;\n        font-weight: 700 !important;\n        color: var(--dlw-blue-dark) !important;\n        font-size: 1.1em !important;\n        margin: 0 !important;\n    }\n\n    \/* Responsive *\/\n    @media (max-width: 768px) {\n        .dlw-lead-box { padding: 1.8em !important; }\n        .dlw-check-list { grid-template-columns: 1fr !important; padding: 1.5em !important; }\n        .dlw-news-img { max-width: 100% !important; }\n        .dlw-panels-grid { grid-template-columns: 1fr !important; } \/* Blindaje UX: Apila a 1 columna en m\u00f3vil *\/\n    }\n<\/style>\n\n<!-- ==========================================\n     CONTENIDO UNIFICADO Y BLINDADO\n     ========================================== -->\n<div class=\"dlw-prod-wrapper\">\n\n    <!-- Descripci\u00f3n Corta (Lead) -->\n    <div class=\"dlw-lead-box\">\n        <p>Bruker&#8217;s <strong>CosMX&#x2122; Spatial Molecular Imager (SMI)<\/strong> is an advanced platform for in situ multi-omic spatial analysis at the single-cell level.<\/p>\n        \n        <p>CosMx SMI is the only in situ imaging platform that offers single-cell spatial biology of the whole transcriptome with unparalleled accuracy, sensitivity, and genomic breadth. It provides spatial multi-omics on formalin-fixed paraffin-embedded (FFPE) and fresh frozen (FF) tissue samples with single-cell and subcellular resolution.<\/p>\n        \n        <p>CosMx SMI enables rapid quantification and visualization of the whole transcriptome (WTX) and 64 validated proteins, offering best-in-class performance for the discovery of unknown and unexpected biology. Capture the history of every cell-to-cell interaction in a whole tissue section with this industry-leading single-cell spatial imaging platform and gain deeper insights for cell atlasing, tissue phenotyping, cell-cell interactions, cellular processes, and biomarker discovery.<\/p>\n    <\/div>\n\n    <!-- Aspectos Clave -->\n    <h2>Key Features<\/h2>\n    \n    <div class=\"dlw-check-list\">\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Unparalleled sensitivity:<\/strong> superior detection efficiency to obtain the highest number of transcripts and unique genes per cell without damaging the tissue.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Maximum single-cell plexity:<\/strong> the first and only spatial platform capable of visualizing the entire protein-coding transcriptome in every cell and more than 64 proteins.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Most accurate cell segmentation:<\/strong> leading AI algorithms for the most precise definition of cell boundaries and transcript assignment to individual cells.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Pre-defined and customizable assays:<\/strong> 1K, 6K, WTX RNA, and 72 proteins.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>AtoMx spatial informatics platform:<\/strong> study-level data exploration suite with flexible export formats for open-source analysis.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Same-cell multi-omics:<\/strong> add another dimension by combining WTX RNA and 72 proteins in the same cell.<\/span>\n        <\/div>\n    <\/div>\n\n    <!-- \u00bfC\u00f3mo funciona? -->\n    <h2>How does it work?<\/h2>\n    \n    <p>CosMx SMI is an integrated system with mature cyclic fluorescent in situ hybridization (FISH) chemistry, high-resolution imaging, and interactive software for data analysis and visualization.<\/p>\n    \n    <div class=\"dlw-news-img-wrapper\">\n        <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/03\/Cosmx1-1.webp\" alt=\"CosMx SMI Integrated System\" class=\"dlw-news-img\" title=\"\">\n    <\/div>\n\n    <h3>Simple sample preparation, compatible with any sample type<\/h3>\n    <p>Streamlined and simple workflow that integrates with standard ISH protocols, without the need for tissue expansion or clearing, cDNA synthesis, or amplification. Go from sample to result faster.<\/p>\n\n    <div class=\"dlw-news-img-wrapper\">\n        <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/03\/Cosmx2-1.webp\" alt=\"CosMx Sample Preparation\" class=\"dlw-news-img\" title=\"\">\n    <\/div>\n\n    <h3>Automated cyclic in situ hybridization chemistry<\/h3>\n    <p>Robust hybridization chemistry that delivers higher sensitivity and supports high-plex assays on your tissue samples to uncover deeper biological insights.<\/p>\n\n    <div class=\"dlw-news-img-wrapper\">\n        <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/03\/Cosmx3-1.webp\" alt=\"Automated Hybridization Chemistry\" class=\"dlw-news-img\" title=\"\">\n    <\/div>\n\n    <!-- Aplicaciones -->\n    <h2>Applications<\/h2>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\"><strong>Cell atlasing and characterization:<\/strong> define cell types, cell states, tissue microenvironment phenotypes, and gene expression networks within the spatial context.<\/span>\n        <span class=\"dlw-list-item\"><strong>Ligand-receptor interaction:<\/strong> analyze the expression and interactions of up to 100 classical ligand-receptor pairs between interacting cells.<\/span>\n        <span class=\"dlw-list-item\"><strong>Biomarker discovery:<\/strong> quantify gene expression changes based on treatment and identify subcellular biomarkers from a single cell with spatial context.<\/span>\n        <span class=\"dlw-list-item\"><strong>Disease state:<\/strong> visualize and quantify molecular (RNA\/protein) and cellular organizational changes in a tissue.<\/span>\n        <span class=\"dlw-list-item\"><strong>Tissue microenvironment:<\/strong> understand cellular neighborhoods by examining individual cells and their interacting neighboring cells.<\/span>\n    <\/div>\n\n    <!-- Paneles disponibles -->\n    <h2>Available Panels<\/h2>\n    <p>Flexible options to meet your research needs. The major panels of this technology are:<\/p>\n\n    <!-- Imagen Inyectada -->\n    <div class=\"dlw-news-img-wrapper\">\n        <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/03\/Imagen1-2.webp\" alt=\"Major CosMx Panels\" class=\"dlw-news-img\" title=\"\">\n    <\/div>\n\n    <p>To learn more about these or other panels, click on the corresponding icon:<\/p>\n\n    <!-- Grid de Paneles (Actualizado a 4 con im\u00e1genes reales y links) -->\n    <div class=\"dlw-panels-grid\">\n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/cosmx-spatial-molecular-imager\/cosmx-rna-assays\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\">\n            <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/03\/1.webp\" alt=\"RNA Assays\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\"><strong>RNA Assays<\/strong><\/p>\n        <\/a>\n        \n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/cosmx-spatial-molecular-imager\/cosmx-protein-assays\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\">\n            <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/03\/2.webp\" alt=\"Protein Assays\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\"><strong>Protein Assays<\/strong><\/p>\n        <\/a>\n\n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/cosmx-spatial-molecular-imager\/cosmx-custom-solutions\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\">\n            <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/03\/3.svg\" alt=\"Custom Assays\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\"><strong>Custom Assays<\/strong><\/p>\n        <\/a>\n\n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/cosmx-spatial-molecular-imager\/cosmx-same-cell-multiomics\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\">\n            <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/03\/Multiomicss.webp\" alt=\"Multiomics Assays\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\"><strong>Multiomics Assays<\/strong><\/p>\n        <\/a>\n    <\/div>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Bruker&#8217;s CosMX&#x2122; Spatial Molecular Imager (SMI) is an advanced platform for in situ multi-omic spatial analysis at the single-cell level. CosMx SMI is the only in situ imaging platform that offers single-cell spatial biology of the whole transcriptome with unparalleled accuracy, sensitivity, and genomic breadth. It provides spatial multi-omics on formalin-fixed paraffin-embedded (FFPE) and fresh [&hellip;]<\/p>\n","protected":false},"featured_media":26829,"template":"","tecnologias":[273],"marcas":[238],"familias":[285,359,360,361,365],"class_list":["post-26834","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-geomx-digital-spatial-profiler-en","marcas-bruker-en","familias-omics","familias-space-biology","familias-proteomics","familias-single-cell-en","familias-transcriptomics"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/26834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":2,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/26834\/revisions"}],"predecessor-version":[{"id":26845,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/26834\/revisions\/26845"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/26829"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=26834"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=26834"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=26834"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=26834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}