{"id":27046,"date":"2026-04-13T07:29:49","date_gmt":"2026-04-13T07:29:49","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=27046"},"modified":"2026-04-13T07:29:49","modified_gmt":"2026-04-13T07:29:49","slug":"agilent-sureselect-clinical-research-exome-v4-cre-v4","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/agilent-sureselect-clinical-research-exome-v4-cre-v4\/","title":{"rendered":"Agilent SureSelect Clinical Research Exome V4 (CRE V4)"},"content":{"rendered":"\n<!-- Bloque de Estilos Scoped (Aislados, Blindados y Escalados a 14px) -->\n<style>\n    \/* Importaci\u00f3n de fuentes corporativas *\/\n    @import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:wght@400;700&family=Raleway:wght@300;400;500;600;700&display=swap');\n\n    \/* Contenedor Principal Aislado *\/\n    .dlw-prod-wrapper {\n        font-family: 'Raleway', sans-serif !important;\n        color: #000000 !important;\n       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to provide <strong>comprehensive coverage of coding regions<\/strong>, with additional content in <strong>clinically relevant non-coding regions<\/strong>.<\/p>\n    <\/div>\n\n    <!-- Descripci\u00f3n Detallada -->\n    <h2>Detailed Description<\/h2>\n\n    <h3>Operating Principle<\/h3>\n    <p>SureSelect Clinical Research Exome V4 is based on library preparation and exome capture enrichment, combining broad coverage of human coding regions with enhanced content in clinically relevant non-coding regions. Its design incorporates genomic findings and includes curated deep intronic sites, mini-genomes, and additional content associated with disease and clinical applications.<\/p>\n    <p>The workflow is compatible with the <strong>SureSelect XT HS2<\/strong> library preparation and enrichment system.<\/p>\n\n    <h3>Clinical Applications<\/h3>\n    <p>Geared towards the identification of causal variants of genetically based diseases in selected coding and non-coding regions.<\/p>\n\n    <h3>Benefits<\/h3>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\"><strong>Improved identification<\/strong> of disease-causing variants.<\/span>\n        <span class=\"dlw-list-item\"><strong>Speed and simplicity<\/strong> of an exome workflow, avoiding the cost burden, infrastructure, and bioinformatics complexity typical of WGS.<\/span>\n        <span class=\"dlw-list-item\"><strong>Highly uniform enrichment.<\/strong><\/span>\n        <span class=\"dlw-list-item\"><strong>Efficient sequencing<\/strong> and native automation on Bravo and Magnis systems.<\/span>\n    <\/div>\n\n    <h3>Key Results or Indicators<\/h3>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\"><strong>Coverage:<\/strong> The panel covers a 41.1 Mb target region with a design size of 48.5 Mb.<\/span>\n        <span class=\"dlw-list-item\"><strong>Theoretical database coverage:<\/strong> 100% of the coding content of CCDS, GENCODE, and RefSeq; 100% of ClinVar P\/LP variants; 100% of HGMD non-coding DM variants, and >99.9% of variants in the 73 ACMG genes.<\/span>\n    <\/div>\n\n    <h3>Technology Used<\/h3>\n    <p>The NGS workflow relies on <strong>SureSelect XT HS2<\/strong> for library preparation and capture enrichment.<\/p>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\"><strong>Validated automation<\/strong> on the Agilent Bravo Automated Liquid Handling platform and Agilent Magnis NGS Prep system.<\/span>\n        <span class=\"dlw-list-item\"><strong>Optimized sequencing<\/strong> for Illumina platforms.<\/span>\n    <\/div>\n\n    <!-- Imagen -->\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/04\/03tecnologia.webp\" alt=\"SureSelect Clinical Research Exome V4 Technology\" class=\"dlw-prod-img\" title=\"\">\n\n    <!-- P\u00fablico \/ Usuario Previsto -->\n    <h2>Intended Audience \/ User<\/h2>\n    <p>This product is intended for clinical genetics and molecular diagnostics laboratories that require a complete workflow, from sample to result or report generation, with extensive automation capabilities.<\/p>\n\n    <!-- Aspectos Clave -->\n    <h2>Key Features<\/h2>\n    \n    <div class=\"dlw-check-list\">\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Exome with 41.1 Mb coverage<\/strong> and an efficient 48.5 Mb design.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Database integration:<\/strong> coding regions from CCDS, GENCODE, and RefSeq, and clinically relevant, curated non-coding content from ClinVar, HGMD, and ACMG.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Includes:<\/strong> TERT promoter region, mitochondrial genome, and pharmacogenomic SNPs.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Incorporates 41 complete mini-genomes<\/strong> (including DMD), and probes for 43 loci related to repeat expansion disorders.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Multiplex detection:<\/strong> enables the detection of SNVs, indels, and CNVs in a single workflow.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Native automation:<\/strong> fully compatible with Agilent Bravo and Magnis systems.<\/span>\n        <\/div>\n    <\/div>\n\n    <!-- Detalles de Presentaci\u00f3n (Acordeones Desplegables) -->\n    <h2>Ordering Information<\/h2>\n\n    <details class=\"dlw-accordion\">\n        <summary class=\"dlw-accordion-header\">SureSelect XT HS Clinical Research Exome V4<\/summary>\n        <div class=\"dlw-accordion-content\">\n            <table class=\"dlw-table\">\n                <tbody>\n                    <tr>\n                        <td width=\"30%\" class=\"dlw-ref-code\">5280-0020<\/td>\n                        <td width=\"70%\">16 reactions<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">5280-0021<\/td>\n                        <td>96 reactions<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">5280-0022<\/td>\n                        <td>96 reactions Auto<\/td>\n                    <\/tr>\n                <\/tbody>\n            <\/table>\n        <\/div>\n    <\/details>\n\n    <details class=\"dlw-accordion\">\n        <summary class=\"dlw-accordion-header\">SureSelect XT PreCap Clinical Research Exome V4<\/summary>\n        <div class=\"dlw-accordion-content\">\n            <table class=\"dlw-table\">\n                <tbody>\n                    <tr>\n                        <td width=\"30%\" class=\"dlw-ref-code\">5280-0029<\/td>\n                        <td width=\"70%\">2 hybridizations<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">5280-0030<\/td>\n                        <td>12 hybridizations<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">5280-0031<\/td>\n                        <td>12 hybridizations Auto<\/td>\n                    <\/tr>\n                <\/tbody>\n            <\/table>\n        <\/div>\n    <\/details>\n\n    <details class=\"dlw-accordion\">\n        <summary class=\"dlw-accordion-header\">Magnis SureSelect XT HS2 DNA CRE V4 ILM<\/summary>\n        <div class=\"dlw-accordion-content\">\n            <table class=\"dlw-table\">\n                <tbody>\n                    <tr>\n                        <td width=\"30%\" class=\"dlw-ref-code\">G9775A<\/td>\n                        <td width=\"70%\">32 reactions<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">G9775B<\/td>\n                        <td>96 reactions<\/td>\n                    <\/tr>\n                <\/tbody>\n            <\/table>\n        <\/div>\n    <\/details>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Exome designed to provide comprehensive coverage of coding regions, with additional content in clinically relevant non-coding regions. Detailed Description Operating Principle SureSelect Clinical Research Exome V4 is based on library preparation and exome capture enrichment, combining broad coverage of human coding regions with enhanced content in clinically relevant non-coding regions. Its design incorporates genomic findings [&hellip;]<\/p>\n","protected":false},"featured_media":27038,"template":"","tecnologias":[36],"marcas":[526],"familias":[283,297,425],"class_list":["post-27046","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-next-generation-sequencing-ngs","marcas-agilent-en","familias-molecular-genetics","familias-exomes","familias-hereditary_and_or_rare_diseases"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27046","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27046\/revisions"}],"predecessor-version":[{"id":27047,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27046\/revisions\/27047"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/27038"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=27046"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=27046"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=27046"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=27046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}