{"id":27064,"date":"2026-04-13T07:58:30","date_gmt":"2026-04-13T07:58:30","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=27064"},"modified":"2026-04-13T07:58:30","modified_gmt":"2026-04-13T07:58:30","slug":"franklin-by-qiagen-para-analisis-germinal","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/franklin-by-qiagen-para-analisis-germinal\/","title":{"rendered":"Franklin by QIAGEN para an\u00e1lisis germinal"},"content":{"rendered":"\n<!-- Bloque de Estilos Scoped (Aislados, Blindados y Escalados a 14px) -->\n<style>\n    \/* Importaci\u00f3n de fuentes corporativas *\/\n    @import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:wght@400;700&family=Raleway:wght@300;400;500;600;700&display=swap');\n\n    \/* Contenedor Principal Aislado *\/\n    .dlw-prod-wrapper {\n        font-family: 'Raleway', sans-serif !important;\n        color: #000000 !important;\n        line-height: 1.6 !important;\n        background-color: transparent !important;\n        padding: 0 !important;\n        max-width: 100% !important;\n        text-align: left !important;\n        display: block !important;\n        font-size: 14px !important; 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}\n        .dlw-highlight-box { padding: 1.5em !important; }\n        .dlw-check-list { grid-template-columns: 1fr !important; padding: 1.5em !important; }\n        .dlw-software-img { max-width: 100% !important; }\n    }\n<\/style>\n\n<!-- ==========================================\n     CONTENIDO UNIFICADO Y BLINDADO\n     ========================================== -->\n<div class=\"dlw-prod-wrapper\">\n\n    <!-- Descripci\u00f3n Corta (Lead Box) -->\n    <div class=\"dlw-lead-box\">\n        <p><strong>Franklin by QIAGEN<\/strong> is a cloud-based bioinformatics platform designed for the management, analysis, and interpretation of human genomic data. The solution centralizes case evaluation, quality control, variant prioritization, and classification into a structured workflow, facilitating the review and interpretation of complex sequencing data for specialized professionals.<\/p>\n    <\/div>\n\n    <!-- Imagen Principal (URL Actualizada a ENG) -->\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/04\/imagen-soluciones-franklin-eng.webp\" alt=\"Franklin by QIAGEN Solutions\" class=\"dlw-software-img\" title=\"\">\n\n    <!-- Descripci\u00f3n Detallada -->\n    <h2>Detailed Description<\/h2>\n    \n    <p>This cloud-based bioinformatics software has been developed for the analysis of germline variants from processed human genomic data. Its comprehensive approach allows working with FASTQ, BAM, and VCF files, applying validated bioinformatics <em>pipelines<\/em> for alignment, variant calling, annotation, interpretation, and custom report generation.<\/p>\n\n    <p>Franklin integrates genomic, phenotypic, and technical case information into a single environment, bringing together clinical metadata, HPO terms, panels, quality control metrics, and analysis results. This unified vision optimizes the workflow and promotes a more agile, structured, and consistent review.<\/p>\n\n    <!-- Foco de atenci\u00f3n t\u00e1ctico: La Inteligencia Artificial -->\n    <div class=\"dlw-highlight-box\">\n        <p>Furthermore, its <strong>artificial intelligence-driven prioritization engine<\/strong> selects the variants most likely to be relevant for each case and presents them in the <em>Workbench<\/em> for review. This prioritization incorporates automatic classification according to ACMG\/AMP guidelines, genotype-phenotype correlation, inheritance models, family segregation, and technical metrics associated with variant confidence.<\/p>\n    <\/div>\n\n    <p>To strengthen interpretation, Franklin consolidates evidence from more than 100 sources of genetic, genic, and phenotypic information, including public databases, internal laboratory data, and real-time community curation. Thus, it provides a robust environment for variant evaluation and the standardization of review criteria.<\/p>\n\n    <!-- Aplicaciones cl\u00ednicas -->\n    <h3>Clinical Applications<\/h3>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Data analysis from whole exome sequencing (WES), whole genome sequencing (WGS), chromosomal microarrays (CMA), and gene panels.<\/span>\n        <span class=\"dlw-list-item\">Interpretation of variants associated with hereditary diseases.<\/span>\n        <span class=\"dlw-list-item\">Evaluation of single nucleotide variants (SNPs and indels), copy number variants (CNVs), and more complex variants.<\/span>\n        <span class=\"dlw-list-item\">Analysis of individual cases, trios, and extended families, including automatic checks such as consanguinity, family relationship verification, and uniparental disomy (UPD) in familial cases.<\/span>\n    <\/div>\n\n    <!-- Beneficios -->\n    <h3>Benefits<\/h3>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Franklin stands out for its ability to <strong>centralize on a single platform<\/strong> all relevant case information, simplifying the review and improving process traceability.<\/span>\n        <span class=\"dlw-list-item\">It allows starting the evaluation from a shortlist of <strong>AI-prioritized variants<\/strong>, accelerating interpretation and facilitating clinical decision-making.<\/span>\n        <span class=\"dlw-list-item\">It incorporates <strong>specific tools for CNV interpretation<\/strong>, featuring detailed visualization, dosage sensitivity information, clinical evidence, and internal occurrence data.<\/span>\n        <span class=\"dlw-list-item\">It promotes the <strong>standardization of the laboratory workflow<\/strong>, enabling internal variant classification, as well as community-level classification and frequency tracking.<\/span>\n    <\/div>\n\n    <!-- P\u00fablico \/ Usuario previsto -->\n    <h3>Intended Audience \/ User<\/h3>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Software solution aimed at laboratories, hospitals, and organizations specializing in genetic analysis, interpretation, and reporting in a research environment.<\/span>\n        <span class=\"dlw-list-item\">Especially suitable for laboratories seeking a centralized, scalable, and structured tool for germline variant interpretation.<\/span>\n    <\/div>\n\n    <!-- Aspectos Clave -->\n    <h2>Key Features<\/h2>\n    \n    <div class=\"dlw-check-list\">\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Comprehensive platform<\/strong> for the analysis and interpretation of germline variants, enabling a sample-to-custom-report workflow.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Full compatibility<\/strong> with FASTQ, BAM, and VCF data.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Variant prioritization<\/strong> using artificial intelligence algorithms.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Automatic classification<\/strong> strictly aligned with ACMG\/AMP guidelines criteria.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Advanced interpretation<\/strong> of copy number variants (CNVs) and structural variants.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Integration of over 100 sources<\/strong> of genetic and phenotypic evidence in real-time.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Centralized management<\/strong> of case, phenotype, quality control, evaluation, and classification in a single environment.<\/span>\n        <\/div>\n    <\/div>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Franklin by QIAGEN is a cloud-based bioinformatics platform designed for the management, analysis, and interpretation of human genomic data. The solution centralizes case evaluation, quality control, variant prioritization, and classification into a structured workflow, facilitating the review and interpretation of complex sequencing data for specialized professionals. Detailed Description This cloud-based bioinformatics software has been developed [&hellip;]<\/p>\n","protected":false},"featured_media":27056,"template":"","tecnologias":[],"marcas":[244],"familias":[283,336,456,457,347],"class_list":["post-27064","productos","type-productos","status-publish","has-post-thumbnail","hentry","marcas-verogen-en","familias-molecular-genetics","familias-oncohematology","familias-software-en","familias-software-solutions-for-germline-analysis","familias-solid-tumor"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27064","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":2,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27064\/revisions"}],"predecessor-version":[{"id":27066,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27064\/revisions\/27066"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/27056"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=27064"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=27064"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=27064"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=27064"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}