{"id":27075,"date":"2026-04-13T08:09:43","date_gmt":"2026-04-13T08:09:43","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=27075"},"modified":"2026-04-13T08:12:27","modified_gmt":"2026-04-13T08:12:27","slug":"twist-cnv-backbone-spike-in-panels","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/twist-cnv-backbone-spike-in-panels\/","title":{"rendered":"Twist CNV Backbone Spike-in Panels"},"content":{"rendered":"\n<!-- Bloque de Estilos Scoped (Aislados, Blindados y Escalados a 14px) -->\n<style>\n    \/* Importaci\u00f3n de fuentes corporativas *\/\n    @import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:wght@400;700&family=Raleway:wght@300;400;500;600;700&display=swap');\n\n    \/* Contenedor Principal Aislado *\/\n    .dlw-prod-wrapper {\n        font-family: 'Raleway', sans-serif !important;\n        color: #000000 !important;\n        line-height: 1.6 !important;\n        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border: none !important; position: relative !important; padding-left: 45% !important; }\n        .dlw-table td::before { position: absolute !important; top: 15px !important; left: 15px !important; width: 40% !important; white-space: nowrap !important; font-weight: bold !important; color: var(--dlw-blue-dark) !important; font-size: 0.9em !important; text-transform: uppercase !important; }\n        .dlw-table td:nth-of-type(1)::before { content: \"Reference\" !important; }\n        .dlw-table td:nth-of-type(2)::before { content: \"Description\" !important; }\n    }\n<\/style>\n\n<!-- ==========================================\n     CONTENIDO UNIFICADO Y BLINDADO\n     ========================================== -->\n<div class=\"dlw-prod-wrapper\">\n\n    <!-- Descripci\u00f3n Corta (Lead Box) -->\n    <div class=\"dlw-lead-box\">\n        <p>Spike-in panels designed to complement exome sequencing through evenly distributed genome-wide coverage, aimed at improving the detection of copy number variations (CNVs). Available in three probe densities\u2014100 kb, 50 kb, and 25 kb\u2014they seamlessly integrate into standard Twist target enrichment and capture workflows.<\/p>\n    <\/div>\n\n    <!-- Descripci\u00f3n Detallada -->\n    <h2>Detailed Description<\/h2>\n\n    <h3>Operating Principle<\/h3>\n    <p>Exome sequencing focuses on coding regions and other specific areas of interest, which typically represent only about 1\u20132% of the genome. This limitation leaves large intergenic regions out of the analysis and hampers CNV detection when the exome is used on its own.<\/p>\n    <p>Twist CNV Backbone Spike-in panels add a series of probes distributed at regular intervals across the genome to improve resolution in CNV calling. These probes target common and polymorphic SNPs across multiple populations and are spaced at 25 kb, 50 kb, or 100 kb, depending on the resolution required by each laboratory.<\/p>\n\n    <h3>Clinical Applications<\/h3>\n    <p>Designed for cytogenetic research, this panel expands the scope of exome sequencing in the analysis of samples with clinically relevant chromosomal alterations. It facilitates genome-wide CNV detection, including large events that traditionally required techniques such as CMA or aCGH. Furthermore, it adds value to comprehensive variant studies by enabling the simultaneous analysis of CNVs, LOH, SNVs, and small indels within a single NGS approach.<\/p>\n\n    <h3>Benefits<\/h3>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Allows adjusting the resolution of CNV analysis without changing the overall laboratory workflow or adding extra tests.<\/span>\n        <span class=\"dlw-list-item\">Helps specialists better delineate the breakpoints of deletions and duplications, extracting exceptional performance in detecting these alterations via NGS.<\/span>\n        <span class=\"dlw-list-item\">Designed to pair with Twist exome panels, easily integrating as a secondary spike-in panel.<\/span>\n        <span class=\"dlw-list-item\">Comparative studies report a 100% concordance between CNVs detected by NGS and aCGH data.<\/span>\n    <\/div>\n\n    <!-- Imagen -->\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/04\/Cuadro-CNVs-eng.webp\" alt=\"CNV Performance Chart\" class=\"dlw-prod-img\" title=\"\">\n\n    <h3>Intended Audience \/ User<\/h3>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Aimed at laboratories and professionals performing exome sequencing who need to incorporate copy number variation (CNV) analysis into their workflows, with the ability to adjust study resolution based on the goals of each analysis.<\/span>\n    <\/div>\n\n    <!-- Aspectos Clave -->\n    <h2>Key Features<\/h2>\n    \n    <div class=\"dlw-check-list\">\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Adds CNV analysis capability to exome studies via a spike-in panel; it is not intended as a replacement for the core panel itself.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Available in three resolutions: 25 kb, 50 kb, and 100 kb.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Utilizes probes targeting polymorphic SNPs distributed across intergenic and intronic regions.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Compatible with the Twist Exome 2.0 plus Comprehensive Spike-in Panel and Twist library preparation and target enrichment workflows.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Comparative studies show 100% concordance with CNVs detected by aCGH and better breakpoint definition compared to exome alone.<\/span>\n        <\/div>\n    <\/div>\n\n    <!-- Detalles de Presentaci\u00f3n (Acordeones Desplegables) -->\n    <h2>Ordering Information<\/h2>\n\n    <details class=\"dlw-accordion\">\n        <summary class=\"dlw-accordion-header\">Commercial Configurations<\/summary>\n        <div class=\"dlw-accordion-content\">\n            <table class=\"dlw-table\">\n                <tbody>\n                    <tr>\n                        <td width=\"30%\" class=\"dlw-ref-code\">2-reaction kit<\/td>\n                        <td width=\"70%\">(16 samples)<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">12-reaction kit<\/td>\n                        <td>(96 samples)<\/td>\n                    <\/tr>\n                <\/tbody>\n            <\/table>\n        <\/div>\n    <\/details>\n\n    <details class=\"dlw-accordion\">\n        <summary class=\"dlw-accordion-header\">Available Resolutions<\/summary>\n        <div class=\"dlw-accordion-content\">\n            <table class=\"dlw-table\">\n                <tbody>\n                    <tr>\n                        <td width=\"30%\" class=\"dlw-ref-code\">110756 \/ 110757<\/td>\n                        <td width=\"70%\">25 kb: high resolution (8.32 Mb)<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">110758 \/ 110759<\/td>\n                        <td>50 kb: intermediate resolution (3.33 Mb)<\/td>\n                    <\/tr>\n                    <tr>\n                        <td class=\"dlw-ref-code\">110760 \/ 110761<\/td>\n                        <td>100 kb: lower resolution (1.39 Mb)<\/td>\n                    <\/tr>\n                <\/tbody>\n            <\/table>\n        <\/div>\n    <\/details>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Spike-in panels designed to complement exome sequencing through evenly distributed genome-wide coverage, aimed at improving the detection of copy number variations (CNVs). Available in three probe densities\u2014100 kb, 50 kb, and 25 kb\u2014they seamlessly integrate into standard Twist target enrichment and capture workflows. Detailed Description Operating Principle Exome sequencing focuses on coding regions and other [&hellip;]<\/p>\n","protected":false},"featured_media":27071,"template":"","tecnologias":[36],"marcas":[242],"familias":[283,426,425],"class_list":["post-27075","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-next-generation-sequencing-ngs","marcas-twist-bioscience-en","familias-molecular-genetics","familias-genomes","familias-hereditary_and_or_rare_diseases"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27075","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27075\/revisions"}],"predecessor-version":[{"id":27076,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27075\/revisions\/27076"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/27071"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=27075"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=27075"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=27075"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=27075"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}