{"id":27151,"date":"2026-04-13T11:20:34","date_gmt":"2026-04-13T11:20:34","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=27151"},"modified":"2026-04-13T11:22:37","modified_gmt":"2026-04-13T11:22:37","slug":"kmrtype-kmrtrack","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/kmrtype-kmrtrack\/","title":{"rendered":"KMRtype\u00ae \/ KMRtrack\u00ae"},"content":{"rendered":"\n<!-- Bloque de Estilos Scoped (Aislados, Blindados y Escalados a 14px) -->\n<style>\n    \/* Importaci\u00f3n de fuentes corporativas *\/\n    @import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:ital,wght@0,400;0,700;1,400&family=Raleway:wght@300;400;500;600;700&display=swap');\n\n    \/* Contenedor Principal Aislado *\/\n    .dlw-prod-wrapper {\n        font-family: 'Raleway', sans-serif !important;\n        color: #000000 !important;\n        line-height: 1.6 !important;\n        background-color: transparent !important;\n        padding: 0 !important;\n        max-width: 100% !important;\n        text-align: left !important;\n        display: block !important;\n        font-size: 14px !important; 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}\n        .dlw-check-list { grid-template-columns: 1fr !important; padding: 1.5em !important; }\n        .dlw-prod-img { max-width: 100% !important; }\n        .dlw-dual-img-grid { grid-template-columns: 1fr !important; }\n    }\n<\/style>\n\n<!-- ==========================================\n     CONTENIDO UNIFICADO Y BLINDADO\n     ========================================== -->\n<div class=\"dlw-prod-wrapper\">\n\n    <!-- Descripci\u00f3n Corta (Lead Box) -->\n    <div class=\"dlw-lead-box\">\n        <p>Comprehensive solution for chimerism study by qPCR, combining pre-transplant genetic typing kits and post-transplant quantitative monitoring.<\/p>\n    <\/div>\n\n    <!-- Descripci\u00f3n Detallada -->\n    <h2>Detailed Description<\/h2>\n\n    <p>KMRtype\u00ae and KMRtrack\u00ae are complementary systems developed by GenDx for the characterization and monitoring of chimerism in transplant patients, using qPCR-based assays. The system allows everything from the identification of unique informative markers between recipient and donor, to the precise quantification of reference DNA in post-transplant samples.<\/p>\n\n    <!-- Grid Dual para Im\u00e1genes en Paralelo -->\n    <div class=\"dlw-dual-img-grid\">\n        <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/04\/fotoproducto-1.webp\" alt=\"KMRtype and KMRtrack\" title=\"\">\n        <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/04\/Imagen2.webp\" alt=\"KMRtype and KMRtrack Analysis\" title=\"\">\n    <\/div>\n\n    <p>KMRtype\u00ae is a genetic typing kit that allows the selection of informative markers between recipient and donor DNA. Each mix contains three multiplexed primers and is used in pre-transplant settings. The kits are available in Core (30 assays in 10 mixes) and Extended (15 assays in 5 additional mixes) versions, allowing coverage of up to 45 assays in total. This phase is essential to identify which specific markers can be used effectively for monitoring.<\/p>\n\n    <!-- Imagen 3 -->\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/04\/Imagen3.webp\" alt=\"KMRtrack and KMRengine\" class=\"dlw-prod-img\" style=\"max-width: 50% !important;\" title=\"\">\n\n    <p>KMRtrack\u00ae is used for post-transplant monitoring using singleplex qPCR assays. Each marker selected in the typing phase is used to quantify the proportion of reference DNA (either from the recipient or the donor) in the samples, allowing precise monitoring of the patient&#8217;s chimeric status over time. The achieved limit of detection is 0.05%, depending on the amount of DNA used.<\/p>\n\n    <p>Both kits are optimized for use alongside the KMRengine\u00ae software, which guides experimental setup, manages qPCR plates, analyzes results, and automatically reports the chimerism percentage. The platform allows registering multiple samples, designing customized experiments, and visualizing data graphically and chronologically.<\/p>\n\n    <!-- Desempe\u00f1o y validaci\u00f3n -->\n    <h2>Performance and Validation<\/h2>\n    <p>Validation studies showed 100% accuracy in typing and high intra- and inter-batch reproducibility in monitoring. Specificity was confirmed for all markers. Detection tests indicated that the system maintains robust performance with variable amounts of DNA, making it ideal for both clinical and experimental samples.<\/p>\n\n    <!-- Consideraciones importantes -->\n    <h2>Important Considerations<\/h2>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Use with non-human DNA or cfDNA is not recommended.<\/span>\n        <span class=\"dlw-list-item\">The use of at least two informative markers is recommended to avoid false results.<\/span>\n        <span class=\"dlw-list-item\">Reagents are light-sensitive and must be stored at -20 \u00b0C.<\/span>\n        <span class=\"dlw-list-item\">Heparinized samples should not be used, as they interfere with PCR.<\/span>\n        <span class=\"dlw-list-item\">It is necessary to physically separate pre- and post-PCR areas to avoid cross-contamination.<\/span>\n    <\/div>\n\n    <!-- Aplicaciones cl\u00ednicas -->\n    <h2>Clinical Applications<\/h2>\n    <p>This system is indicated for chimerism studies in the context of hematopoietic stem cell transplantation, with special utility in graft monitoring and early detection of relapse. Its sensitivity allows the detection of minimal amounts of donor or recipient-derived DNA, facilitating early therapeutic decisions.<\/p>\n\n    <!-- Aspectos Clave -->\n    <h2>Key Features<\/h2>\n    \n    <div class=\"dlw-check-list\">\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Complete system for chimerism typing and monitoring using qPCR.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Identification of specific informative markers for each donor-recipient pair.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Chimerism detection with sensitivity down to 0.05%.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Optimized protocols for genomic DNA from blood.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Automated analysis with KMRengine\u00ae software.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>High inter-batch reproducibility and accuracy.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Compatible with multiple validated qPCR systems.<\/span>\n        <\/div>\n    <\/div>\n\n    <!-- Detalles de Presentaci\u00f3n -->\n    <h2>Ordering Information<\/h2>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">KMRtype\u00ae RUO &#038; CE-IVD: Core Mixes (30 assays, 24 samples) \u2013 Ref. 8341161 \/ Extended Mixes (15 assays, 24 samples) \u2013 Ref. 8341561<\/span>\n        <span class=\"dlw-list-item\">KMRtrack\u00ae RUO &#038; CE-IVD: Core and Extended Kits, 48 reactions per assay \u2013 Ref. 8344162 and 8344562<\/span>\n        <span class=\"dlw-list-item\">KMRassay: Reference Assay (REF901) and Buffer &#038; Enzyme \u2013 288 reactions \u2013 Ref. 8343264 and 8343263<\/span>\n        <span class=\"dlw-list-item\">Versions also available as CE-IVD (see specific references in the IFU)<\/span>\n        <span class=\"dlw-list-item\">For use with KMRengine\u00ae software (included in the GenDx platform)<\/span>\n        <span class=\"dlw-list-item\">Store at -20 \u00b0C, protected from light<\/span>\n    <\/div>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Comprehensive solution for chimerism study by qPCR, combining pre-transplant genetic typing kits and post-transplant quantitative monitoring. Detailed Description KMRtype\u00ae and KMRtrack\u00ae are complementary systems developed by GenDx for the characterization and monitoring of chimerism in transplant patients, using qPCR-based assays. The system allows everything from the identification of unique informative markers between recipient and donor, [&hellip;]<\/p>\n","protected":false},"featured_media":27142,"template":"","tecnologias":[275],"marcas":[221],"familias":[284,320,319],"class_list":["post-27151","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-rt-pcr-en","marcas-gendx-en","familias-immunology","familias-chimerism","familias-post-transplantation"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27151","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27151\/revisions"}],"predecessor-version":[{"id":27152,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27151\/revisions\/27152"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/27142"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=27151"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=27151"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=27151"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=27151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}