{"id":27254,"date":"2026-04-14T08:46:50","date_gmt":"2026-04-14T08:46:50","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=27254"},"modified":"2026-04-14T08:55:51","modified_gmt":"2026-04-14T08:55:51","slug":"devyser-lynchfap","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/devyser-lynchfap\/","title":{"rendered":"Devyser LynchFAP"},"content":{"rendered":"\n<!-- Scoped Styles Block (Isolated, Shielded, and Scaled to 14px) -->\n<style>\n    \/* Corporate fonts import *\/\n    @import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:ital,wght@0,400;0,700;1,400&family=Raleway:wght@300;400;500;600;700&display=swap');\n\n    \/* Isolated Main Container *\/\n    .dlw-prod-wrapper {\n        font-family: 'Raleway', sans-serif !important;\n        color: #000000 !important;\n        line-height: 1.6 !important;\n        background-color: transparent !important;\n        padding: 0 !important;\n        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!important; margin-bottom: 15px !important; }\n        .dlw-table td { border: none !important; position: relative !important; padding-left: 45% !important; }\n        .dlw-table td::before { position: absolute !important; top: 15px !important; left: 15px !important; width: 40% !important; white-space: nowrap !important; font-weight: bold !important; color: var(--dlw-blue-dark) !important; font-size: 0.9em !important; text-transform: uppercase !important; }\n        .dlw-table td:nth-of-type(1)::before { content: \"Reference\" !important; }\n        .dlw-table td:nth-of-type(2)::before { content: \"Description\" !important; }\n    }\n<\/style>\n\n<!-- ==========================================\n     UNIFIED AND SHIELDED CONTENT\n     ========================================== -->\n<div class=\"dlw-prod-wrapper\">\n\n    <!-- Short Description (Lead Box) -->\n    <div class=\"dlw-lead-box\">\n        <p>Devyser LynchFAP is a targeted NGS solution for the analysis of germline variants associated with hereditary colorectal cancer syndromes. The assay enables the detection of SNVs, indels, and CNVs in genes related to Lynch syndrome, familial adenomatous polyposis (FAP), and MUTYH-associated polyposis (MAP), also incorporating a specific LR-PCR for the correct localization of variants in PMS2 versus its pseudogene PMS2CL.<\/p>\n    <\/div>\n\n    <!-- Key Aspects -->\n    <h2>Key Aspects<\/h2>\n    \n    <!-- Part 1 of the grid to maintain text flow and inject the image -->\n    <div class=\"dlw-check-list dlw-check-list-no-bottom\" style=\"padding-bottom: 1em !important;\">\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Detection of SNVs, indels, and CNVs in 10 genes associated with cancer predisposition syndromes: MLH1, MSH2, MSH6, PMS2, EPCAM, APC, MUTYH, POLE, POLD1, and CTNNB1.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>The design also covers the APC 1B promoter, CTNNB1 exon 3, EPCAM exon 9 and 3&#8242; UTR region, and specific defined mutations for POLD1 and POLE.&nbsp;&nbsp;<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Inclusion of a specific Long-range PCR for PMS2, aimed at differentiating variants of the gene from the PMS2CL pseudogene.<\/span>\n        <\/div>\n    <\/div>\n\n    <!-- Image 1 -->\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/04\/Imagen1-eng.webp\" alt=\"Devyser LynchFAP Coverage\" class=\"dlw-prod-img\" style=\"margin: 0 auto 0 auto !important; background-color: var(--dlw-light-bg) !important; padding: 0 2.5em !important; max-width: 100% !important; border-radius: 0 !important;\" title=\"\">\n\n    <!-- Part 2 of the grid -->\n    <div class=\"dlw-check-list dlw-check-list-no-top\" style=\"padding-top: 1.5em !important;\">\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span>Dedicated software: Provides automated and easy-to-use analysis, with efficient variant analysis without the need for bioinformatics expertise.<\/span>\n        <\/div>\n    <\/div>\n\n    <!-- Clinical applications -->\n    <h2>Clinical applications<\/h2>\n    <p>The kit is intended for the study of genes associated with hereditary gastrointestinal cancer syndromes, including MLH1, MSH2, MSH6, PMS2, and EPCAM for Lynch syndrome; APC for FAP; MUTYH for MAP; POLD1 and POLE for colon cancer; and CTNNB1, associated with endometrial cancer.&nbsp;<\/p>\n\n    <!-- Intended audience\/user -->\n    <h2>Intended audience\/user<\/h2>\n    <p>Molecular biology laboratories and research centers with an interest in a targeted evaluation and simplified workflow of genes involved in hereditary cancer syndromes using NGS.<\/p>\n\n    <!-- Benefits -->\n    <h2>Benefits<\/h2>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Simplified workflow: easy to implement and suitable for laboratories with different sample volume needs.&nbsp;&nbsp;<\/span>\n        <span class=\"dlw-list-item\">Ready-to-use reagents, ensuring a reproducible process and reducing the risk of sample mix-up or contamination.&nbsp; &nbsp;&nbsp;<\/span>\n        <span class=\"dlw-list-item\">Integration of a specific LR-PCR for PMS2, which allows for more reliable discrimination of true gene variants versus the homologous regions of PMS2CL.<\/span>\n        <span class=\"dlw-list-item\">Dedicated software that provides fast and intuitive results, without prior bioinformatics knowledge. A specific module is included to evaluate PMS2\/PMS2CL gene conversion events.<\/span>\n    <\/div>\n\n    <!-- Image 2 -->\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/04\/Imagen2-eng.webp\" alt=\"Devyser LynchFAP Software\" class=\"dlw-prod-img\" title=\"\">\n\n    <!-- Presentation Details (Dropdown Accordions) -->\n    <h2>Presentation Details<\/h2>\n\n    <details class=\"dlw-accordion\">\n        <summary class=\"dlw-accordion-header\">Main reagents<\/summary>\n        <div class=\"dlw-accordion-content\">\n            <table class=\"dlw-table\">\n                <tbody>\n                    <tr>\n                        <td width=\"30%\" class=\"dlw-ref-code\">8-A404-8<\/td>\n                        <td width=\"70%\">Devyser LynchFAP 8 tests<\/td>\n                    <\/tr>\n                <\/tbody>\n            <\/table>\n        <\/div>\n    <\/details>\n\n    <details class=\"dlw-accordion\">\n        <summary class=\"dlw-accordion-header\">Additional reagents<\/summary>\n        <div class=\"dlw-accordion-content\">\n            <table class=\"dlw-table\">\n                <tbody>\n                    <tr>\n                        <td width=\"30%\" class=\"dlw-ref-code\">8-A204<\/td>\n                        <td width=\"70%\">Devyser Library Clean<\/td>\n                    <\/tr>\n                <\/tbody>\n            <\/table>\n        <\/div>\n    <\/details>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Devyser LynchFAP is a targeted NGS solution for the analysis of germline variants associated with hereditary colorectal cancer syndromes. The assay enables the detection of SNVs, indels, and CNVs in genes related to Lynch syndrome, familial adenomatous polyposis (FAP), and MUTYH-associated polyposis (MAP), also incorporating a specific LR-PCR for the correct localization of variants in [&hellip;]<\/p>\n","protected":false},"featured_media":27250,"template":"","tecnologias":[36],"marcas":[514],"familias":[283,445,441],"class_list":["post-27254","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-next-generation-sequencing-ngs","marcas-dvysr_en","familias-molecular-genetics","familias-hereditary_cancer","familias-targeted_study_of_specific_pathologies"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27254\/revisions"}],"predecessor-version":[{"id":27255,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27254\/revisions\/27255"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/27250"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=27254"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=27254"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=27254"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=27254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}