{"id":27347,"date":"2026-05-15T09:29:09","date_gmt":"2026-05-15T09:29:09","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=27347"},"modified":"2026-05-15T09:35:32","modified_gmt":"2026-05-15T09:35:32","slug":"geomx-digital-spatial-profiler-dsp","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/geomx-digital-spatial-profiler-dsp\/","title":{"rendered":"GeoMx&#x2122; Digital Spatial Profiler (DSP)"},"content":{"rendered":"\n<!-- Bloque de Estilos Scoped (Aislados, Blindados y Escalados a 14px) -->\n<style>\n    \/* Importaci\u00f3n de fuentes corporativas *\/\n    @import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:ital,wght@0,400;0,700;1,400&family=Raleway:wght@300;400;500;600;700&display=swap');\n\n    \/* Contenedor Principal Aislado *\/\n    .dlw-prod-wrapper {\n        font-family: 'Raleway', sans-serif !important;\n        color: #000000 !important;\n        line-height: 1.6 !important;\n        background-color: transparent !important;\n        padding: 0 !important;\n        max-width: 100% !important;\n        text-align: left !important;\n        display: block !important;\n        font-size: 14px !important; 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padding: 1.5em !important; }\n        .dlw-prod-img { max-width: 100% !important; }\n        .dlw-panels-grid { grid-template-columns: 1fr !important; } \/* 1 columna en m\u00f3vil *\/\n        .dlw-panels-grid-2col { grid-template-columns: 1fr !important; }\n    }\n<\/style>\n\n<!-- ==========================================\n     CONTENIDO UNIFICADO Y BLINDADO\n     ========================================== -->\n<div class=\"dlw-prod-wrapper\">\n\n    <!-- Descripci\u00f3n Corta (Lead Box) -->\n    <div class=\"dlw-lead-box\">\n        <p>Bruker&#8217;s GeoMx&#x2122; Digital Spatial Profiler (DSP) is an advanced platform for multi-omic spatial analysis that enables simultaneous quantification of RNA and proteins in tissue sections, preserving tissue architecture. GeoMx DSP combines fluorescent imaging with photo-cleavable oligonucleotide barcodes, offering digitally quantified molecular profiles in defined regions of interest (ROI).<\/p>\n    <\/div>\n\n    <!-- Descripci\u00f3n Detallada -->\n    <p>This technology supports FFPE and fresh frozen (FF) samples, and allows the selection of specific tissue areas to obtain expression data with spatial resolution, through an automated and scalable workflow that integrates with standard histological staining techniques. GeoMx DSP offers a high level of multiplexing: from targeted panels to whole transcriptome via NGS, along with over 1,200 validated proteins, providing a comprehensive view of the tissue microenvironment.<\/p>\n\n    <p>With GeoMx DSP, researchers can map the spatial distribution of biomarkers, explore cellular interactions, and characterize complex biological processes in their native context. It is ideal for studies in oncology, immunology, neuroscience, and drug development, facilitating biomarker discovery and a deep understanding of spatial biology.<\/p>\n\n    <!-- Aspectos Clave -->\n    <h2>Key Features<\/h2>\n    \n    <div class=\"dlw-check-list\">\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>High sensitivity:<\/strong> 5-log dynamic range and digital readout for quantitative detection of low-expression targets.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Multi-omic assay:<\/strong> the only platform enabling the integration of whole transcriptome and high-plex protein assays (+1,200). Does not damage tissue.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Unmatched protein plexity:<\/strong> the largest antibody-based spatial proteomic assay (+1,200), an order of magnitude higher than any other.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Flexible resolution:<\/strong> segmentation and enrichment of RNA\/protein information from discrete or rare cell populations. Proven protein detection.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>High throughput:<\/strong> rapid collection of RNA\/protein information, compared to cyclic imaging systems, for downstream readout by NGS or nCounter.<\/span>\n        <\/div>\n        <div class=\"dlw-check-item\">\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n            <span><strong>Cost-effective:<\/strong> hypothesis-driven and region-of-interest-directed analysis, investing time and resources only in structures and cells of interest.<\/span>\n        <\/div>\n    <\/div>\n\n    <!-- \u00bfC\u00f3mo funciona? -->\n    <h2>How does it work?<\/h2>\n    \n    <p>Whole slides are stained with assay probes and up to four fluorescent markers (morphology markers), and subsequently imaged on the instrument. Guided by the morphology markers, the regions of interest (ROI) of the tissue to be profiled are chosen, and by using masks (areas of illumination, AOI), two or more tissue compartments or cell types within each ROI can optionally be profiled. RNA and protein expression levels are quantified by direct digital counting of barcodes using the nCounter\u00ae system or by sequencing on an Illumina platform. Data is analyzed using the open-source DSP Data Analysis (DSPDA) suite.<\/p>\n\n    <!-- Imagen 1 -->\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/05\/Imagen1-eng-2.webp\" alt=\"GeoMx DSP Workflow\" class=\"dlw-prod-img\" title=\"\">\n\n    <p>DSP probes are labeled with unique oligonucleotide barcodes that are released upon UV light exposure, without damaging the tissue.<\/p>\n    \n    <!-- Imagen 2 (Hecha mucho m\u00e1s peque\u00f1a y centrada) -->\n    <div style=\"max-width: 350px !important; margin: 2.5em auto !important; text-align: center !important;\">\n        <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/05\/Imagen2-eng.webp\" alt=\"GeoMx Probes and Barcodes\" class=\"dlw-prod-img\" style=\"margin: 0 auto !important; width: 100% !important;\" title=\"\">\n    <\/div>\n\n    <p>Tissue samples are stained with imaging probes (morphology markers) and fluorophore-labeled assay probes using a standard histological workflow.<\/p>\n\n    <p>Regions of interest (ROIs) and areas of illumination (AOIs) are selected on the tissue for interrogation. The tissue is exposed to UV light, and the barcodes are released and subsequently quantified.<\/p>\n    \n    <!-- Imagen 3 -->\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/05\/Imagen3-eng.webp\" alt=\"Selection of ROIs and AOIs\" class=\"dlw-prod-img\" title=\"\">\n    \n    <p>Unbiased spatial expression is obtained from each tissue mask, with the sensitivity to detect low, medium, and high expressors.<\/p>\n\n    <!-- Aplicaciones -->\n    <h2>Applications<\/h2>\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Discovery of predictive biomarkers for therapeutic response.<\/span>\n        <span class=\"dlw-list-item\">Tumor microenvironment profiling.<\/span>\n        <span class=\"dlw-list-item\">Identification of drug mechanisms of action.<\/span>\n        <span class=\"dlw-list-item\">Revelation of molecular subtypes.<\/span>\n        <span class=\"dlw-list-item\">Understanding disease mechanisms and progression.<\/span>\n        <span class=\"dlw-list-item\">Study of preclinical models.<\/span>\n    <\/div>\n\n    <!-- Imagen 4 (Movida aqu\u00ed, m\u00e1s peque\u00f1a y centrada) -->\n    <div style=\"max-width: 350px !important; margin: 2.5em auto !important; text-align: center !important;\">\n        <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/05\/Imagen4-eng.webp\" alt=\"Spatial expression and profiling\" class=\"dlw-prod-img\" style=\"margin: 0 auto !important; width: 100% !important;\" title=\"\">\n    <\/div>\n\n    <!-- Paneles disponibles (Grid T\u00e1ctico de 3 columnas) -->\n    <h2>Available panels:<\/h2>\n    <p>Flexible options to meet your research needs. For more information, click on the corresponding icon:<\/p>\n\n    <h3>GeoMx DSP RNA Assays<\/h3>\n\n    <!-- Grid de Paneles (3x2) -->\n    <div class=\"dlw-panels-grid\">\n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/geomx-digital-spatial-profiler\/geomx-rna-assays\/geomx-human-whole-transcriptome-atlas\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\" style=\"width: 200px !important; min-height: 300px !important; margin: 0 auto !important; padding: 1.5em 1em !important; box-sizing: border-box !important;\">\n            <img decoding=\"async\" src=\"https:\/\/brukerspatialbiology.com\/wp-content\/uploads\/2025\/09\/GeoMx_WTA_wheel_R2-480x480.png\" alt=\"GeoMx Human Whole Transcriptome Atlas\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\">GeoMx\u00ae Human Whole Transcriptome Atlas<\/p>\n        <\/a>\n        \n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/geomx-digital-spatial-profiler\/geomx-rna-assays\/geomx-mouse-whole-transcriptome-atlas\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\" style=\"width: 200px !important; min-height: 300px !important; margin: 0 auto !important; padding: 1.5em 1em !important; box-sizing: border-box !important;\">\n            <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/05\/GeoMx\u00ae-Mouse-Whole-Transcriptome-Atlas.webp\" alt=\"GeoMx Mouse Whole Transcriptome Atlas\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\">GeoMx\u00ae Mouse Whole Transcriptome Atlas<\/p>\n        <\/a>\n\n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/geomx-digital-spatial-profiler\/geomx-rna-assays\/geomx-cancer-transcriptome-atlas\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\" style=\"width: 200px !important; min-height: 300px !important; margin: 0 auto !important; padding: 1.5em 1em !important; box-sizing: border-box !important;\">\n            <img decoding=\"async\" src=\"https:\/\/brukerspatialbiology.com\/wp-content\/uploads\/2025\/09\/GeoMx_CTA-wheel_R2-300x300.png\" alt=\"GeoMx Cancer Transcriptome Atlas\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\">GeoMx\u00ae Cancer Transcriptome Atlas<\/p>\n        <\/a>\n\n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/geomx-digital-spatial-profiler\/geomx-rna-assays\/geomx-tcr-profiling-add-on\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\" style=\"width: 200px !important; min-height: 300px !important; margin: 0 auto !important; padding: 1.5em 1em !important; box-sizing: border-box !important;\">\n            <img decoding=\"async\" src=\"https:\/\/brukerspatialbiology.com\/wp-content\/uploads\/2025\/09\/GeoMx_TCR-Diversity-Add-On_v6-480x480.png\" alt=\"GeoMx TCR Profiling Add-On\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\">GeoMx\u00ae TCR Profiling Add-On<\/p>\n        <\/a>\n\n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/geomx-digital-spatial-profiler\/geomx-rna-assays\/geomx-canine-cancer-atlas\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\" style=\"width: 200px !important; min-height: 300px !important; margin: 0 auto !important; padding: 1.5em 1em !important; box-sizing: border-box !important;\">\n            <img decoding=\"async\" src=\"https:\/\/brukerspatialbiology.com\/wp-content\/uploads\/2025\/09\/GeoMx-Canine-Cancer-Atlas_R2-350x350.png\" alt=\"GeoMx Canine Cancer Atlas\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\">GeoMx\u00ae Canine Cancer Atlas<\/p>\n        <\/a>\n\n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/geomx-digital-spatial-profiler\/geomx-rna-assays\/immune-pathways-rna-assays\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\" style=\"width: 200px !important; min-height: 300px !important; margin: 0 auto !important; padding: 1.5em 1em !important; box-sizing: border-box !important;\">\n            <img decoding=\"async\" src=\"https:\/\/brukerspatialbiology.com\/wp-content\/uploads\/2025\/09\/DSP_NGS_nCounter_Readout_RNA-Pathway_Wheel-480x480.png\" alt=\"GeoMx Immune Pathways Panel\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\">GeoMx\u00ae Immune Pathways Panel<\/p>\n        <\/a>\n    <\/div>\n\n    <h3>GeoMx DSP Protein Assays<\/h3>\n\n    <!-- Grid de Paneles (2x2) -->\n    <div class=\"dlw-panels-grid-2col\">\n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/geomx-digital-spatial-profiler\/geomx-protein-assays\/discovery-proteome-atlas\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\" style=\"width: 200px !important; min-height: 300px !important; margin: 0 auto !important; padding: 1.5em 1em !important; box-sizing: border-box !important;\">\n            <img decoding=\"async\" src=\"https:\/\/brukerspatialbiology.com\/wp-content\/uploads\/2026\/01\/GeoMx_Discovery-Proteome-Atlas-1-600x600-1-300x300.png\" alt=\"GeoMx Discovery Proteome Atlas\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\">GeoMx\u00ae Discovery Proteome Atlas<\/p>\n        <\/a>\n        \n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/geomx-digital-spatial-profiler\/geomx-protein-assays\/io-proteome-atlas\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\" style=\"width: 200px !important; min-height: 300px !important; margin: 0 auto !important; padding: 1.5em 1em !important; box-sizing: border-box !important;\">\n            <img decoding=\"async\" src=\"https:\/\/brukerspatialbiology.com\/wp-content\/uploads\/2025\/08\/GeoMx_IO-Proteome-Atlas_r6-480x480.png\" alt=\"GeoMx ImmunoOncology Proteome Atlas\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\">GeoMx\u00ae ImmunoOncology Proteome Atlas<\/p>\n        <\/a>\n\n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/geomx-digital-spatial-profiler\/geomx-protein-assays\/geomx-immuno-oncology-protein-panels\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\" style=\"width: 200px !important; min-height: 300px !important; margin: 0 auto !important; padding: 1.5em 1em !important; box-sizing: border-box !important;\">\n            <img decoding=\"async\" src=\"https:\/\/brukerspatialbiology.com\/wp-content\/uploads\/2025\/08\/GeoMx_IO-Protein-350x350.png\" alt=\"GeoMx Immuno-Oncology Protein Panels\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\">GeoMx\u00ae Immuno-Oncology Protein Panels<\/p>\n        <\/a>\n\n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/geomx-digital-spatial-profiler\/geomx-protein-assays\/geomx-neuroscience-protein-panels\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\" style=\"width: 200px !important; min-height: 300px !important; margin: 0 auto !important; padding: 1.5em 1em !important; box-sizing: border-box !important;\">\n            <img decoding=\"async\" src=\"https:\/\/brukerspatialbiology.com\/wp-content\/uploads\/2025\/08\/GeoMx_Neuroscience-Protein-Panels-350x350.png\" alt=\"GeoMx Neuroscience Protein Panels\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\">GeoMx\u00ae Neuroscience Protein Panels<\/p>\n        <\/a>\n    <\/div>\n\n    <h3>GeoMx DSP Custom Assays<\/h3>\n\n    <!-- Grid de Paneles (2x1) -->\n    <div class=\"dlw-panels-grid-2col\">\n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/geomx-digital-spatial-profiler\/geomx-custom-solutions\/geomx-rna-barcoding-service-rbs\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\" style=\"width: 200px !important; min-height: 300px !important; margin: 0 auto !important; padding: 1.5em 1em !important; box-sizing: border-box !important;\">\n            <img decoding=\"async\" src=\"https:\/\/brukerspatialbiology.com\/wp-content\/uploads\/2025\/09\/GeoMx_Custom-Solutions_R2-480x480.png\" alt=\"GeoMx RNA Barcoding Service (RBS)\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\">GeoMx\u00ae RNA Barcoding Service (RBS)<\/p>\n        <\/a>\n        \n        <a href=\"https:\/\/brukerspatialbiology.com\/products\/geomx-digital-spatial-profiler\/geomx-custom-solutions\/protein-barcoding-service-pbs\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"dlw-panel-card\" style=\"width: 200px !important; min-height: 300px !important; margin: 0 auto !important; padding: 1.5em 1em !important; box-sizing: border-box !important;\">\n            <img decoding=\"async\" src=\"https:\/\/brukerspatialbiology.com\/wp-content\/uploads\/2025\/09\/GeoMx_Custom-Solutions-Protein-Barcoding_R2-350x350.png\" alt=\"GeoMx Protein Barcoding Service (PBS)\" class=\"dlw-panel-img\" title=\"\">\n            <p class=\"dlw-panel-title\">GeoMx\u00ae Protein Barcoding Service (PBS)<\/p>\n        <\/a>\n    <\/div>\n\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bruker&#8217;s GeoMx&#x2122; Digital Spatial Profiler (DSP) is an advanced platform for multi-omic spatial analysis that enables simultaneous quantification of RNA and proteins in tissue sections, preserving tissue architecture. GeoMx DSP combines fluorescent imaging with photo-cleavable oligonucleotide barcodes, offering digitally quantified molecular profiles in defined regions of interest (ROI). This technology supports FFPE and fresh frozen [&hellip;]<\/p>\n","protected":false},"featured_media":27346,"template":"","tecnologias":[273],"marcas":[238],"familias":[285,359,360,365],"class_list":["post-27347","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-geomx-digital-spatial-profiler-en","marcas-bruker-en","familias-omics","familias-space-biology","familias-proteomics","familias-transcriptomics"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27347","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27347\/revisions"}],"predecessor-version":[{"id":27348,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27347\/revisions\/27348"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/27346"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=27347"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=27347"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=27347"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=27347"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}