{"id":27788,"date":"2026-06-17T11:40:12","date_gmt":"2026-06-17T11:40:12","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=27788"},"modified":"2026-06-17T11:44:28","modified_gmt":"2026-06-17T11:44:28","slug":"hedera-profiling-ctdna-3","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/hedera-profiling-ctdna-3\/","title":{"rendered":"Hedera Profiling ctDNA 3"},"content":{"rendered":"\n<!-- Scoped Styles Block (Isolated, Shielded, and Scaled to 14px) -->\n\n<style>\n\n    \/* Corporate font import *\/\n\n    @import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:ital,wght@0,400;0,700;1,400&family=Raleway:wght@300;400;500;600;700&display=swap');\n\n\n\n    \/* Main Isolated Container *\/\n\n    .dlw-prod-wrapper {\n\n        font-family: 'Raleway', sans-serif !important;\n\n        color: #000000 !important;\n\n        line-height: 1.6 !important;\n\n        background-color: transparent 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========================================== -->\n\n<div class=\"dlw-prod-wrapper\">\n\n\n\n    <!-- Short Description (Lead Box) -->\n\n    <div class=\"dlw-lead-box\">\n\n        <p>In\u2011house targeted enrichment NGS panel exclusively for liquid biopsy (cfDNA). It analyzes 43 genes with ESCAT I and II clinical evidence. Includes library preparation through an optimized workflow (DNA\u2011only) for plasma samples. Detects SNVs, Indels, CNVs, fusions and 36 microsatellite instability (MSI) markers.<\/p>\n\n    <\/div>\n\n\n\n    <!-- Detailed Description -->\n\n    <h2>Detailed Description<\/h2>\n\n\n\n    <h3>Principle of operation<\/h3>\n\n    <p>End\u2011to\u2011end solution based on hybridisation and capture enrichment chemistry for the analysis of 43 genes. The assay consolidates processing into a single workflow exclusively for cell\u2011free DNA (cfDNA). It stands out for requiring highly competitive minimum inputs, starting from <strong>10 ng<\/strong> (with <strong>30 ng<\/strong> recommended for high\u2011quality data).<\/p>\n\n    <p>The assay allows analysis of SNVs, Indels, copy number variations (CNVs), fusions and 36 microsatellite instability (MSI) markers. In addition, it includes critical alterations such as METex14 skipping, EGFR vIII variant and large Indels in BRCA1\/2.<\/p>\n\n    <p><strong>Analytical Sensitivity:<\/strong><\/p>\n\n    <p>\u2022 <strong>cfDNA samples (Liquid Biopsy):<\/strong> Detects variants with allelic frequencies (VAF) down to <strong>0.5%<\/strong> for SNVs, Indels and fusions.<\/p>\n\n\n\n    <!-- Image 1 -->\n\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/06\/Imagen-1.webp\" alt=\"Hedera Profiling 3 principle of operation\" class=\"dlw-prod-img\" onclick=\"openDlwModal(this.src)\" title=\"\">\n\n\n\n    <p>Library preparation integrates UMI adapters and UDI primers with duplex consensus reading to maximise data reliability, correcting errors and preventing index hopping. After an overnight 16\u2011hour hybridisation, the system delivers sequencing\u2011ready libraries for compatible platforms in just 2 days, allowing multiplexing of up to 4 samples per capture.<\/p>\n\n\n\n    <!-- Image 2 (English) -->\n\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/06\/Imagen-2-eng-1.webp\" alt=\"Hedera Profiling 3 workflow\" class=\"dlw-prod-img\" onclick=\"openDlwModal(this.src)\" title=\"\">\n\n\n\n    <p>The analysis is comprehensively completed through <strong>Hedera Prime (CE\u2011IVDR)<\/strong>, a secondary and tertiary analysis software that automates quality control and variant interpretation, presenting results through specific interfaces optimised for each type of genomic alteration.<\/p>\n\n\n\n    <!-- Image 3 (English) -->\n\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/06\/Imagen-3-eng.webp\" alt=\"Hedera Prime software\" class=\"dlw-prod-img\" onclick=\"openDlwModal(this.src)\" title=\"\">\n\n\n\n    <h3>Clinical applications<\/h3>\n\n    <p>This tool has been designed for advanced molecular profiling of solid tumours through exclusive liquid biopsy analysis (PSO). The assay has validated the evaluation of biomarkers with ESCAT I and II evidence levels (prioritised by ESMO guidelines) for multiple clinical indications (non\u2011small cell lung cancer [NSCLC], colorectal, cholangiocarcinoma, gastric, thyroid, breast, prostate, pancreatic, hepatocellular, ovarian, endometrial, urothelial and soft tissue sarcomas).<\/p>\n\n\n\n    <!-- Image 4 (English) -->\n\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/06\/Imagen-4-eng.webp\" alt=\"Hedera Profiling 3 clinical applications\" class=\"dlw-prod-img\" onclick=\"openDlwModal(this.src)\" title=\"\">\n\n\n\n    <h3>Benefits<\/h3>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">Consolidated DNA\u2011only workflow exclusively for liquid biopsy (cfDNA) sample processing with PSO marking.<\/span>\n\n        <span class=\"dlw-list-item\">Comprehensive genomic coverage of 43 genes for the evaluation of SNVs, Indels, CNVs, fusions and 36 MSI markers in a single assay.<\/span>\n\n        <span class=\"dlw-list-item\">Incorporation of UMI technology and UDI primers for error correction and index hopping prevention.<\/span>\n\n        <span class=\"dlw-list-item\">Performance optimisation with minimum sample inputs from 10 ng of cfDNA.<\/span>\n\n        <span class=\"dlw-list-item\">Validated compatibility for sequencing runs on Illumina and Element Biosciences AVITI platforms.<\/span>\n\n        <span class=\"dlw-list-item\">Integration of secondary and tertiary bioinformatic analysis through Hedera Prime software with CE\u2011IVDR marking.<\/span>\n\n    <\/div>\n\n\n\n    <h3>Intended user \/ audience<\/h3>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">Laboratories and research groups dedicated to the study, diagnosis and monitoring of solid tumours, regardless of whether the starting material is Plasma.<\/span>\n\n    <\/div>\n\n\n\n    <!-- Key Features -->\n\n    <h2>Key Features<\/h2>\n\n    \n\n    <div class=\"dlw-check-list\">\n\n        <div class=\"dlw-check-item\">\n\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n\n            <span>Genomic coverage of 43 genes for performance studies from liquid biopsy (cfDNA) with PSO marking.<\/span>\n\n        <\/div>\n\n        <div class=\"dlw-check-item\">\n\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n\n            <span>Detection of single nucleotide variants (SNVs), insertions\/deletions (Indels), copy number variations (CNVs), fusions and 36 microsatellite instability (MSI) markers, including complex variants such as METex14 skipping, EGFR vIII variant and large Indels in BRCA1\/2.<\/span>\n\n        <\/div>\n\n        <div class=\"dlw-check-item\">\n\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n\n            <span>Design focused on solid tumours, integrating biomarkers with ESCAT I and II clinical evidence levels (prioritised by ESMO guidelines) for multiple indications.<\/span>\n\n        <\/div>\n\n        <div class=\"dlw-check-item\">\n\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n\n            <span>Design based on hybrid capture enrichment, integrating UMI adapters and duplex consensus UDI primers for read error correction.<\/span>\n\n        <\/div>\n\n        <div class=\"dlw-check-item\">\n\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n\n            <span>Optimised workflow that allows processing up to 4 samples per capture (24 reactions per kit) with a recommended input of 30 ng of cfDNA.<\/span>\n\n        <\/div>\n\n        <div class=\"dlw-check-item\">\n\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n\n            <span>Processing capability for sequencing runs on Illumina (NextSeq, NovaSeq) and Element Biosciences AVITI systems.<\/span>\n\n        <\/div>\n\n        <div class=\"dlw-check-item\">\n\n            <svg class=\"dlw-check-icon\" viewBox=\"0 0 24 24\"><path d=\"M12 2C6.48 2 2 6.48 2 12s4.48 10 10 10 10-4.48 10-10S17.52 2 12 2zm-2 15l-5-5 1.41-1.41L10 14.17l7.59-7.59L19 8l-9 9z\"\/><\/svg>\n\n            <span>Automated analysis through the Hedera Prime platform, CE\u2011IVDR marked software that centralises secondary quality control and tertiary variant interpretation.<\/span>\n\n        <\/div>\n\n    <\/div>\n\n\n\n    <!-- Presentation Details (Accordions) -->\n\n    <h2>Presentation Details<\/h2>\n\n\n\n    <details class=\"dlw-accordion\">\n\n        <summary class=\"dlw-accordion-header\">Product identification<\/summary>\n\n        <div class=\"dlw-accordion-content\">\n\n            <div class=\"dlw-list\">\n\n                <span class=\"dlw-list-item\">Commercial name: Hedera Profiling 3 ctDNA Test Panel.<\/span>\n\n                <span class=\"dlw-list-item\">Product type: Full Solution.<\/span>\n\n                <span class=\"dlw-list-item\">Product family: Assay Enrichment Kit + Hedera Prime Analytics.<\/span>\n\n                <span class=\"dlw-list-item\">Product ID: T24-4LP324I<\/span>\n\n                <span class=\"dlw-list-item\">Product version: 2.0.<\/span>\n\n                <span class=\"dlw-list-item\">Sample type: cfDNA (liquid biopsy).<\/span>\n\n            <\/div>\n\n        <\/div>\n\n    <\/details>\n\n\n\n    <details class=\"dlw-accordion\">\n\n        <summary class=\"dlw-accordion-header\">Kit contents<\/summary>\n\n        <div class=\"dlw-accordion-content\">\n\n            <div class=\"dlw-list\">\n\n                <span class=\"dlw-list-item\">Library preparation, Indexing, Purification and isolation.<\/span>\n\n            <\/div>\n\n        <\/div>\n\n    <\/details>\n\n\n\n    <details class=\"dlw-accordion\">\n\n        <summary class=\"dlw-accordion-header\">Required materials (Not included)<\/summary>\n\n        <div class=\"dlw-accordion-content\">\n\n            <div class=\"dlw-list\">\n\n                <span class=\"dlw-list-item\">Quantification and Quality Control (QC): Fluorometric quantification kits and fragment size assessment kits.<\/span>\n\n                <span class=\"dlw-list-item\">Sequencing: Reagents for sequencing runs on Illumina platforms and Illumina PhiX v3 control.<\/span>\n\n            <\/div>\n\n        <\/div>\n\n    <\/details>\n\n\n\n    <!-- Modal Structure (Lightbox) -->\n\n    <div id=\"dlw-image-modal\" class=\"dlw-modal\">\n\n        <span class=\"dlw-modal-close\" onclick=\"closeDlwModal()\">&times;<\/span>\n\n        <img decoding=\"async\" class=\"dlw-modal-img\" id=\"dlw-modal-img-target\" src=\"\" alt=\"\" title=\"\">\n\n    <\/div>\n\n\n\n<\/div>\n\n\n\n<!-- Modal Script (Vanilla JS, no dependencies) -->\n\n<script>\n\n    function openDlwModal(src) {\n\n        var modal = document.getElementById('dlw-image-modal');\n\n        var modalImg = document.getElementById('dlw-modal-img-target');\n\n        modalImg.src = src;\n\n        modal.classList.add('dlw-active');\n\n        document.body.style.overflow = 'hidden'; \/\/ Locks background scroll\n\n    }\n\n\n\n    function closeDlwModal() {\n\n        var modal = document.getElementById('dlw-image-modal');\n\n        modal.classList.remove('dlw-active');\n\n        document.body.style.overflow = 'auto'; \/\/ Restores scroll\n\n    }\n\n\n\n    \/\/ Closes modal if clicking outside the image\n\n    document.getElementById('dlw-image-modal').addEventListener('click', function(e) {\n\n        if (e.target === this) {\n\n            closeDlwModal();\n\n        }\n\n    });\n\n\n\n    \/\/ Closes modal with ESC key\n\n    document.addEventListener('keydown', function(e) {\n\n        if (e.key === \"Escape\" && document.getElementById('dlw-image-modal').classList.contains('dlw-active')) {\n\n            closeDlwModal();\n\n        }\n\n    });\n\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>In\u2011house targeted enrichment NGS panel exclusively for liquid biopsy (cfDNA). It analyzes 43 genes with ESCAT I and II clinical evidence. Includes library preparation through an optimized workflow (DNA\u2011only) for plasma samples. Detects SNVs, Indels, CNVs, fusions and 36 microsatellite instability (MSI) markers. Detailed Description Principle of operation End\u2011to\u2011end solution based on hybridisation and capture [&hellip;]<\/p>\n","protected":false},"featured_media":27783,"template":"","tecnologias":[36],"marcas":[249],"familias":[347,459],"class_list":["post-27788","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-next-generation-sequencing-ngs","marcas-hederadx-en","familias-solid-tumor","familias-liquid-biopsy"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27788","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27788\/revisions"}],"predecessor-version":[{"id":27789,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/27788\/revisions\/27789"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/27783"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=27788"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=27788"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=27788"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=27788"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}