{"id":28011,"date":"2026-07-21T10:46:02","date_gmt":"2026-07-21T10:46:02","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=28011"},"modified":"2026-07-21T10:49:34","modified_gmt":"2026-07-21T10:49:34","slug":"genvinset-deltaf508","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/genvinset-deltaf508\/","title":{"rendered":"Genvinset\u00ae deltaF508"},"content":{"rendered":"\n<!-- Scoped Styles Block (Isolated, Shielded, and Scaled to 14px) -->\n\n<style>\n\n    \/* Corporate font import *\/\n\n    @import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:ital,wght@0,400;0,700;1,400&family=Raleway:wght@300;400;500;600;700&display=swap');\n\n\n\n    \/* Main Isolated Container *\/\n\n    .dlw-prod-wrapper {\n\n        font-family: 'Raleway', sans-serif !important;\n\n        color: #000000 !important;\n\n        line-height: 1.6 !important;\n\n        background-color: transparent !important;\n\n        padding: 0 !important;\n\n        max-width: 100% !important;\n\n        text-align: left !important;\n\n        display: block !important;\n\n        font-size: 14px !important; \/* ANCHOR: Ignores defective root size from Bricks *\/\n\n    }\n\n\n\n    \/* Local CSS Variables *\/\n\n    .dlw-prod-wrapper {\n\n        --dlw-blue-dark: #003a70;\n\n        --dlw-blue-cyan: #00a1e0;\n\n        --dlw-light-bg: #f9fbfd;\n\n        --dlw-grey-bg: #f4f6f8;\n\n        --dlw-border: #e1e8f0;\n\n        --dlw-grey: #939598;\n\n    }\n\n\n\n    \/* H2 Headings *\/\n\n    .dlw-prod-wrapper h2 {\n\n        font-family: 'Playfair Display', serif !important;\n\n        color: var(--dlw-blue-dark) !important;\n\n        margin-top: 2em !important;\n\n        margin-bottom: 0.8em !important;\n\n        font-size: 1.8em !important;\n\n        font-weight: 700 !important;\n\n        border-bottom: 2px solid var(--dlw-border) !important;\n\n        padding-bottom: 10px !important;\n\n        display: block !important;\n\n    }\n\n\n\n    \/* H3 Headings *\/\n\n    .dlw-prod-wrapper h3 {\n\n        font-family: 'Playfair Display', serif !important;\n\n        color: var(--dlw-blue-cyan) !important;\n\n        margin-top: 1.5em !important;\n\n        margin-bottom: 0.5em !important;\n\n        font-size: 1.4em !important;\n\n        font-weight: 700 !important;\n\n        display: block !important;\n\n    }\n\n\n\n    \/* Standard paragraphs *\/\n\n    .dlw-prod-wrapper p {\n\n        font-weight: 400 !important;\n\n        margin-bottom: 1.2em !important;\n\n        text-align: justify !important;\n\n        font-size: 1.25em !important;\n\n        color: #333333 !important;\n\n    }\n\n\n\n    \/* Corporate bold text *\/\n\n    .dlw-prod-wrapper strong {\n\n        color: var(--dlw-blue-dark) !important;\n\n        font-weight: 700 !important;\n\n    }\n\n\n\n    \/* Lead \/ Short Description (Corporate Blue Box) *\/\n\n    .dlw-lead-box {\n\n        background-color: var(--dlw-blue-dark) !important;\n\n        color: #ffffff !important;\n\n        padding: 2.5em 3em !important;\n\n        margin-bottom: 2.5em !important;\n\n        border-radius: 8px !important;\n\n        box-shadow: 0 6px 25px rgba(0, 58, 112, 0.2) !important;\n\n    }\n\n\n\n    .dlw-lead-box p {\n\n        color: #ffffff !important;\n\n        font-size: 1.35em !important;\n\n        font-weight: 500 !important;\n\n        margin-bottom: 0 !important;\n\n        text-align: left !important;\n\n    }\n\n\n\n    \/* Single inserted images (centered) *\/\n\n    .dlw-prod-img {\n\n        width: auto !important;\n\n        max-width: 90% !important;\n\n        height: auto !important;\n\n        display: block !important;\n\n        margin: 2.5em auto !important;\n\n        margin-left: auto !important;\n\n        margin-right: auto !important;\n\n        float: none !important;\n\n        border-radius: 6px !important;\n\n        box-shadow: none !important;\n\n        transition: transform 0.4s cubic-bezier(0.165, 0.84, 0.44, 1) !important;\n\n        cursor: zoom-in !important;\n\n    }\n\n\n\n    .dlw-prod-img:hover {\n\n        transform: scale(1.03) !important;\n\n    }\n\n\n\n    \/* Standard lists (bullets) *\/\n\n    .dlw-list {\n\n        display: flex !important;\n\n        flex-direction: column !important;\n\n        margin-bottom: 2em !important;\n\n        padding-left: 0 !important;\n\n    }\n\n\n\n    .dlw-list-item {\n\n        position: relative !important;\n\n        padding-left: 1.5em !important;\n\n        margin-bottom: 0.8em !important;\n\n        text-align: left !important;\n\n        font-size: 1.25em !important;\n\n        color: #333333 !important;\n\n        display: block !important;\n\n    }\n\n\n\n    .dlw-list-item::before {\n\n        content: \"\u2022\" !important;\n\n        position: absolute !important;\n\n        left: 0 !important;\n\n        color: var(--dlw-blue-cyan) !important;\n\n        font-weight: bold !important;\n\n        font-size: 1.2em !important;\n\n        top: -2px !important;\n\n    }\n\n\n\n    \/* Nested sub-lists *\/\n\n    .dlw-sub-list {\n\n        margin-top: 0.5em !important;\n\n        margin-bottom: 0.5em !important;\n\n        padding-left: 1.5em !important;\n\n    }\n\n\n\n    .dlw-sub-list-item {\n\n        position: relative !important;\n\n        padding-left: 1.2em !important;\n\n        margin-bottom: 0.4em !important;\n\n        font-size: 0.95em !important;\n\n        color: #555555 !important;\n\n        display: block !important;\n\n    }\n\n\n\n    .dlw-sub-list-item::before {\n\n        content: \"-\" !important;\n\n        position: absolute !important;\n\n        left: 0 !important;\n\n        color: var(--dlw-grey) !important;\n\n        font-weight: bold !important;\n\n    }\n\n\n\n    \/* Modal \/ Lightbox *\/\n\n    .dlw-modal {\n\n        display: none;\n\n        position: fixed !important;\n\n        z-index: 999999 !important;\n\n        left: 0 !important;\n\n        top: 0 !important;\n\n        width: 100vw !important;\n\n        height: 100vh !important;\n\n        background-color: rgba(0, 20, 40, 0.85) !important;\n\n        backdrop-filter: blur(5px) !important;\n\n        align-items: center !important;\n\n        justify-content: center !important;\n\n    }\n\n\n\n    .dlw-modal.dlw-active {\n\n        display: flex !important;\n\n        animation: dlw-fade-in 0.3s ease-out forwards;\n\n    }\n\n\n\n    @keyframes dlw-fade-in {\n\n        from { opacity: 0; }\n\n        to { opacity: 1; }\n\n    }\n\n\n\n    .dlw-modal-img {\n\n        max-width: 90vw !important;\n\n        max-height: 90vh !important;\n\n        width: auto !important;\n\n        height: auto !important;\n\n        border-radius: 6px !important;\n\n        box-shadow: 0 10px 40px rgba(0,0,0,0.5) !important;\n\n        object-fit: contain !important;\n\n    }\n\n\n\n    .dlw-modal-close {\n\n        position: absolute !important;\n\n        top: 25px !important;\n\n        right: 35px !important;\n\n        color: #ffffff !important;\n\n        font-size: 45px !important;\n\n        font-weight: 300 !important;\n\n        cursor: pointer !important;\n\n        transition: color 0.3s ease !important;\n\n        line-height: 1 !important;\n\n        z-index: 9999999 !important;\n\n    }\n\n\n\n    .dlw-modal-close:hover {\n\n        color: var(--dlw-blue-cyan) !important;\n\n    }\n\n\n\n    \/* Responsive *\/\n\n    @media (max-width: 768px) {\n\n        .dlw-lead-box { padding: 1.8em !important; }\n\n        .dlw-prod-img { max-width: 100% !important; }\n\n    }\n\n<\/style>\n\n\n\n<!-- ==========================================\n\n     UNIFIED AND SHIELDED CONTENT\n\n     ========================================== -->\n\n<div class=\"dlw-prod-wrapper\">\n\n\n\n    <!-- Short Description (Lead Box) -->\n\n    <div class=\"dlw-lead-box\">\n\n        <p>Genvinset\u00ae deltaF508 is a semi\u2011automated in vitro diagnostic kit for the qualitative detection of wild\u2011type and\/or F508del alleles of the CFTR gene, associated with cystic fibrosis. The assay is performed on genomic DNA extracted from whole blood using real\u2011time PCR with TaqMan\u00ae probes.<\/p>\n\n    <\/div>\n\n\n\n    <!-- Detailed description -->\n\n    <h2>Detailed description<\/h2>\n\n\n\n    <h3>Key features<\/h3>\n\n    <p>Genvinset\u00ae deltaF508 is designed for the molecular determination of the F508del mutation, also known as \u0394F508, in the CFTR gene. This mutation is associated with cystic fibrosis, an autosomal recessive genetic disease that affects various organs and is related to alterations in water and ion transport across the epithelium.<\/p>\n\n\n\n    <h3>Principle of operation<\/h3>\n\n    <p>The assay is based on real\u2011time PCR with TaqMan\u00ae probes. For each sample, a pair of CFTR gene\u2011specific primers and two allele\u2011specific hydrolysis probes are used:<\/p>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">Probe specific for the wild\u2011type allele labelled with HEX.<\/span>\n\n        <span class=\"dlw-list-item\">Probe specific for the F508del allele labelled with FAM.<\/span>\n\n    <\/div>\n\n    <p>Interpretation is performed using the FAM and HEX\/VIC channels:<\/p>\n\n\n\n    <!-- Image 1 -->\n\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/07\/1-1.webp\" alt=\"Genvinset deltaF508 result interpretation\" class=\"dlw-prod-img\" onclick=\"openDlwModal(this.src)\" title=\"\">\n\n\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">wt\/wt samples: signal in HEX and absence of signal or weak signal in FAM.<\/span>\n\n        <span class=\"dlw-list-item\">F508del\/F508del samples: signal in FAM and absence of signal or weak signal in HEX.<\/span>\n\n        <span class=\"dlw-list-item\">wt\/F508del samples: signal in both channels, FAM and HEX.<\/span>\n\n    <\/div>\n\n\n\n    <h3>Clinical applications<\/h3>\n\n    <p>This kit is used as an auxiliary tool for the molecular diagnosis of patients with suspected cystic fibrosis. It is intended for patients referred by a healthcare specialist, taking into account compatible symptoms such as pulmonary infections or pneumonia, wheezing, cough with thick mucus, digestive disorders, difficulty gaining weight or growing, very salty sweat and\/or a family history of cystic fibrosis.<\/p>\n\n    <p>It can also be used in neonatal patients for the molecular confirmation of cystic fibrosis after observing deviations in biochemical newborn screening, especially in the presence of abnormal immunoreactive trypsinogen values.<\/p>\n\n    <p>Assay results should not be used as the sole criterion for therapeutic decision\u2011making, but rather as diagnostic support together with other disease markers and the patient&#8217;s clinical information.<\/p>\n\n\n\n    <h3>Benefits<\/h3>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">Provides a specific solution for the qualitative detection of wild\u2011type and mutant alleles for the F508del variant of the CFTR gene using a technology widely used in molecular diagnostics.<\/span>\n\n        <span class=\"dlw-list-item\">High diagnostic and analytical reliability.<\/span>\n\n        <span class=\"dlw-list-item\">Allows discrimination between wild\u2011type and mutant alleles in a single reaction, facilitating the identification of the three genotypic profiles covered by the assay.<\/span>\n\n        <span class=\"dlw-list-item\">Includes specific controls that ensure standardisation and technical quality checks: wild\u2011type control, F508del mutant control and Reaction Blank as a negative control.<\/span>\n\n        <span class=\"dlw-list-item\">Compatible with most real\u2011time PCR thermal cyclers commonly used in laboratories.<\/span>\n\n    <\/div>\n\n\n\n    <h3>Considerations or limitations<\/h3>\n\n    <p>The product must be used strictly in accordance with the instructions for use. It should not be used if contamination, deterioration, loss of reactivity is suspected, or if the kit has exceeded its expiration date. Genotyping results and their interpretation must be reviewed by qualified personnel.<\/p>\n\n\n\n    <!-- Key features -->\n\n    <h2>Key features<\/h2>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">CE\u2011IVD kit for molecular diagnosis of the F508del mutation of the CFTR gene.<\/span>\n\n        <span class=\"dlw-list-item\">Qualitative detection of wild\u2011type and\/or F508del alleles associated with cystic fibrosis.<\/span>\n\n        <span class=\"dlw-list-item\">Real\u2011time PCR technology with TaqMan\u00ae probes.<\/span>\n\n        <span class=\"dlw-list-item\">Differentiation of wt\/wt, wt\/F508del and F508del\/F508del samples using FAM and HEX\/VIC channels.<\/span>\n\n        <span class=\"dlw-list-item\">Complete kit with included controls, ensuring standardisation and quality control.<\/span>\n\n        <span class=\"dlw-list-item\">Compatible with multiple validated real\u2011time PCR platforms.<\/span>\n\n    <\/div>\n\n\n\n    <!-- Presentation Details -->\n\n    <h2>Presentation Details<\/h2>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">Formats: 24, 48 and 96 tests<\/span>\n\n        <span class=\"dlw-list-item\">References: GVS-DF508-24, GVS-DF508-48, GVS-DF508-96<\/span>\n\n    <\/div>\n\n\n\n    <!-- Modal Structure (Lightbox) -->\n\n    <div id=\"dlw-image-modal\" class=\"dlw-modal\">\n\n        <span class=\"dlw-modal-close\" onclick=\"closeDlwModal()\">&times;<\/span>\n\n        <img decoding=\"async\" class=\"dlw-modal-img\" id=\"dlw-modal-img-target\" src=\"\" alt=\"\" title=\"\">\n\n    <\/div>\n\n\n\n<\/div>\n\n\n\n<!-- Modal Script (Vanilla JS, no dependencies) -->\n\n<script>\n\n    function openDlwModal(src) {\n\n        var modal = document.getElementById('dlw-image-modal');\n\n        var modalImg = document.getElementById('dlw-modal-img-target');\n\n        modalImg.src = src;\n\n        modal.classList.add('dlw-active');\n\n        document.body.style.overflow = 'hidden';\n\n    }\n\n\n\n    function closeDlwModal() {\n\n        var modal = document.getElementById('dlw-image-modal');\n\n        modal.classList.remove('dlw-active');\n\n        document.body.style.overflow = 'auto';\n\n    }\n\n\n\n    document.getElementById('dlw-image-modal').addEventListener('click', function(e) {\n\n        if (e.target === this) {\n\n            closeDlwModal();\n\n        }\n\n    });\n\n\n\n    document.addEventListener('keydown', function(e) {\n\n        if (e.key === \"Escape\" && document.getElementById('dlw-image-modal').classList.contains('dlw-active')) {\n\n            closeDlwModal();\n\n        }\n\n    });\n\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>Genvinset\u00ae deltaF508 is a semi\u2011automated in vitro diagnostic kit for the qualitative detection of wild\u2011type and\/or F508del alleles of the CFTR gene, associated with cystic fibrosis. The assay is performed on genomic DNA extracted from whole blood using real\u2011time PCR with TaqMan\u00ae probes. Detailed description Key features Genvinset\u00ae deltaF508 is designed for the molecular determination [&hellip;]<\/p>\n","protected":false},"featured_media":28006,"template":"","tecnologias":[275],"marcas":[225],"familias":[283,293,441],"class_list":["post-28011","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-rt-pcr-en","marcas-blackhills-diagnostic-resources-en","familias-molecular-genetics","familias-cystic-fibrosis","familias-targeted_study_of_specific_pathologies"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28011","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28011\/revisions"}],"predecessor-version":[{"id":28012,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28011\/revisions\/28012"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/28006"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=28011"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=28011"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=28011"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=28011"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}