{"id":28054,"date":"2026-07-22T08:08:28","date_gmt":"2026-07-22T08:08:28","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=28054"},"modified":"2026-07-22T08:11:40","modified_gmt":"2026-07-22T08:11:40","slug":"karyoseq-integrated-solution-for-pgt-m-pgt-sr-and-pgt-a","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/karyoseq-integrated-solution-for-pgt-m-pgt-sr-and-pgt-a\/","title":{"rendered":"KaryoSeq (Integrated solution for PGT-M, PGT-SR and PGT-A)"},"content":{"rendered":"\n<!-- Scoped Styles Block (Isolated, Shielded, and Scaled to 14px) -->\n\n<style>\n\n    \/* Corporate font import *\/\n\n    @import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:ital,wght@0,400;0,700;1,400&family=Raleway:wght@300;400;500;600;700&display=swap');\n\n\n\n    \/* Main Isolated Container *\/\n\n    .dlw-prod-wrapper {\n\n        font-family: 'Raleway', sans-serif !important;\n\n        color: #000000 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class=\"dlw-lead-box\">\n\n        <p>KaryoSeq&#x2122; is a next\u2011generation sequencing (NGS)\u2011based solution for preimplantation genetic testing that enables PGT\u2011M, PGT\u2011SR and PGT\u2011A within a single workflow. It is designed for the analysis of DNA extracted from 3 to 10 trophectoderm cells of human embryos at the blastocyst stage.<\/p>\n\n    <\/div>\n\n\n\n    <!-- Detailed Description -->\n\n    <h2>Detailed Description<\/h2>\n\n\n\n    <h3>Principle of operation<\/h3>\n\n    <p>KaryoSeq&#x2122; is based on the MARSALA principle and integrates whole\u2011genome amplification of single cells using NGS technology to perform, in a single assay, gene locus analysis, chromosomal alterations and SNP linkage through whole\u2011genome sequencing. The workflow requires the inclusion of an embryo biopsy sample and peripheral blood DNA from relatives to process the data and issue a clinical report.<\/p>\n\n\n\n    <!-- Image 1 -->\n\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/07\/Imagen1en.webp\" alt=\"KaryoSeq principle of operation\" class=\"dlw-prod-img\" onclick=\"openDlwModal(this.src)\" title=\"\">\n\n\n\n    <h3>Clinical applications<\/h3>\n\n    <p>The solution is intended for preimplantation genetic testing for monogenic diseases (PGT\u2011M), chromosomal structural rearrangements (PGT\u2011SR) and aneuploidy screening (PGT\u2011A). The provided material indicates its usefulness in families with a high risk of monogenic diseases, families with chromosomal structural abnormalities such as translocations and duplications, and families with a high risk of aneuploidy, including advanced maternal age, repeated implantation failure and recurrent miscarriages.<\/p>\n\n\n\n    <!-- Image 2 -->\n\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/07\/Imagen2en.webp\" alt=\"KaryoSeq clinical applications\" class=\"dlw-prod-img\" onclick=\"openDlwModal(this.src)\" title=\"\">\n\n\n\n    <h3>Benefits<\/h3>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">It is an all\u2011in\u2011one comprehensive solution for PGT\u2011M\/PGT\u2011SR\/PGT\u2011A, using NGS to address different alterations.<\/span>\n\n        <span class=\"dlw-list-item\">A single sequencing run is required to perform several PGT tests from a single sample, with simple laboratory procedures and a lower cost than separate tests.<\/span>\n\n    <\/div>\n\n\n\n    <h3>Key results or indicators<\/h3>\n\n    <p>This product reports an accuracy rate of 99.9%, coverage of more than 1,000 monogenic diseases and more than 250,000 embryos analysed.<\/p>\n\n\n\n    <!-- Image 3 -->\n\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/07\/Imagen3en.webp\" alt=\"KaryoSeq key results\" class=\"dlw-prod-img\" onclick=\"openDlwModal(this.src)\" title=\"\">\n\n\n\n    <h3>Technology used<\/h3>\n\n    <p>The solution combines whole\u2011genome amplification (WGA), NGS library preparation, sequencing and analysis with ChromGo\u00ae software.<\/p>\n\n\n\n    <!-- Image 4 -->\n\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/07\/Imagen4en.webp\" alt=\"KaryoSeq technology\" class=\"dlw-prod-img\" onclick=\"openDlwModal(this.src)\" title=\"\">\n\n\n\n    <h3>Intended user \/ audience<\/h3>\n\n    <p>Solution for molecular diagnostic laboratories with qualified laboratory personnel to perform the procedures.<\/p>\n\n\n\n    <!-- Key Features -->\n\n    <h2>Key Features<\/h2>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">Comprehensive solution for PGT\u2011M, PGT\u2011SR and PGT\u2011A in a single workflow.<\/span>\n\n        <span class=\"dlw-list-item\">Designed to start from 3 to 10 trophectoderm cells from blastocyst embryos.<\/span>\n\n        <span class=\"dlw-list-item\">Integration with ChromGo\u00ae software for data interpretation.<\/span>\n\n        <span class=\"dlw-list-item\">Aimed at laboratories seeking a complete, operationally simple and cost\u2011effective solution.<\/span>\n\n        <span class=\"dlw-list-item\">Greater efficiency in each sequencing run thanks to the ability to multiplex with other Yikon product line products.<\/span>\n\n    <\/div>\n\n\n\n    <!-- Presentation Details -->\n\n    <h2>Presentation Details<\/h2>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">Solution format: solution applicable to Illumina platform for PGT analysis by NGS.<\/span>\n\n        <span class=\"dlw-list-item\">Documented components\/reagents: ChromSwift\u00ae Universal Sample Preparation Kit (XK-028-24-I1), Sample Preservation Buffer (XK-043), DNA Fragmentation Kit (XK-108004248), NGS Library Preparation Kit (YK001-001) and NGS index kits for Illumina; 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is a next\u2011generation sequencing (NGS)\u2011based solution for preimplantation genetic testing that enables PGT\u2011M, PGT\u2011SR and PGT\u2011A within a single workflow. It is designed for the analysis of DNA extracted from 3 to 10 trophectoderm cells of human embryos at the blastocyst stage. Detailed Description Principle of operation KaryoSeq&#x2122; is based on the MARSALA principle [&hellip;]<\/p>\n","protected":false},"featured_media":28042,"template":"","tecnologias":[36],"marcas":[237],"familias":[283,453,303],"class_list":["post-28054","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-next-generation-sequencing-ngs","marcas-yikon-genomics-en","familias-molecular-genetics","familias-preimplantation-genetic-diagnosis","familias-reproduction"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28054\/revisions"}],"predecessor-version":[{"id":28055,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28054\/revisions\/28055"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/28042"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=28054"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=28054"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=28054"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=28054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}