{"id":28069,"date":"2026-07-22T08:23:50","date_gmt":"2026-07-22T08:23:50","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=28069"},"modified":"2026-07-22T08:25:38","modified_gmt":"2026-07-22T08:25:38","slug":"marecs-mapping-allele-with-resolved-carrier-state-test","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/marecs-mapping-allele-with-resolved-carrier-state-test\/","title":{"rendered":"MaReCs (Mapping allele with resolved carrier state test)"},"content":{"rendered":"\n<!-- Scoped Styles Block (Isolated, Shielded, and Scaled to 14px) -->\n\n<style>\n\n    \/* Corporate font import *\/\n\n    @import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:ital,wght@0,400;0,700;1,400&family=Raleway:wght@300;400;500;600;700&display=swap');\n\n\n\n    \/* Main Isolated Container *\/\n\n    .dlw-prod-wrapper {\n\n        font-family: 'Raleway', sans-serif !important;\n\n        color: #000000 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breakpoints and SNP linkage to differentiate carrier from non\u2011carrier euploid embryos.<\/p>\n\n    <\/div>\n\n\n\n    <!-- Detailed Description -->\n\n    <h2>Detailed Description<\/h2>\n\n\n\n    <h3>Principle of operation<\/h3>\n\n    <p>MaReCs\u00ae combines ChromSwift\u00ae technology with NGS sequencing to perform a CNV analysis and subsequently an SNP linkage analysis. The workflow is divided into two steps:<\/p>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">Step 1: Embryonic CNV analysis using embryo sequencing data.<\/span>\n\n        <span class=\"dlw-list-item\">Step 2: SNP linkage analysis using embryo and family sequencing data.<\/span>\n\n    <\/div>\n\n    <p>This approach allows the identification of translocation breakpoints and distinguishes whether a euploid embryo is a carrier or normal\/non\u2011carrier.<\/p>\n\n\n\n    <!-- Image 1 -->\n\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/07\/Imagen1-1.webp\" alt=\"MaReCs principle of operation\" class=\"dlw-prod-img\" onclick=\"openDlwModal(this.src)\" title=\"\">\n\n\n\n    <h3>Clinical applications<\/h3>\n\n    <p>This technology is positioned for PGT\u2011SR cases and includes the analysis of chromosomal structural rearrangements, being especially relevant in:<\/p>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">Reciprocal translocations (t)<\/span>\n\n        <span class=\"dlw-list-item\">Robertsonian translocations (rob)<\/span>\n\n        <span class=\"dlw-list-item\">Inversions (inv)<\/span>\n\n    <\/div>\n\n    <p>Furthermore, it is important to highlight that it allows discrimination between normal embryos and embryos with balanced translocations, while embryos with duplications\/deletions are discarded for implantation.<\/p>\n\n\n\n    <!-- Image 2 -->\n\n    <img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/07\/Imagen2.webp\" alt=\"MaReCs clinical applications\" class=\"dlw-prod-img\" onclick=\"openDlwModal(this.src)\" title=\"\">\n\n\n\n    <h3>Benefits<\/h3>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">Allows differentiation of carrier euploid embryos from non\u2011carriers through breakpoint analysis and SNP linkage.<\/span>\n\n        <span class=\"dlw-list-item\">Includes the analytical content of PGT\u2011SR and adds a layer of resolution to optimise the selection of non\u2011carrier embryos.<\/span>\n\n        <span class=\"dlw-list-item\">Designed to resolve in a single analytical approach aneuploidy, fragmentary duplications\/deletions, and the distinction between carrier and normal.<\/span>\n\n    <\/div>\n\n\n\n    <h3>Intended user \/ audience<\/h3>\n\n    <p>PGT\u2011SR cases in families with structural chromosomal rearrangements. Validation schemes and use cases include families with inherited translocations and carriers with available relatives for study.<\/p>\n\n\n\n    <h3>Considerations or limitations<\/h3>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">MaReCs\u00ae is documented for translocations, Robertsonian translocations and inversions.<\/span>\n\n        <span class=\"dlw-list-item\">For translocation fragments, the documentation indicates size >1M.<\/span>\n\n        <span class=\"dlw-list-item\">Three scenarios are considered in the validation cases:<\/span>\n\n        <div class=\"dlw-sub-list\">\n\n            <span class=\"dlw-sub-list-item\">couple + carrier&#8217;s parents, no limit on the number of embryos;<\/span>\n\n            <span class=\"dlw-sub-list-item\">couple + affected child, no limit on the number of embryos;<\/span>\n\n            <span class=\"dlw-sub-list-item\">couple alone, with more than 3 embryos.<\/span>\n\n        <\/div>\n\n        <span class=\"dlw-list-item\">For Robertsonian translocations, it is indicated that it must be a whole\u2011arm translocation of known length.<\/span>\n\n        <span class=\"dlw-list-item\">In families with a de novo mutation, MaReCs\u00ae is not applicable.<\/span>\n\n        <span class=\"dlw-list-item\">Carrier distinction requires reference embryos with informative CNV profiles; the document explains that at least one abnormal embryo and one euploid CNV embryo allow the distinction in the translocation context, and that for Robertsonian translocations it is recommended to have 2 abnormal CNV embryos in addition to at least one euploid CNV embryo.<\/span>\n\n    <\/div>\n\n\n\n    <!-- Key Features -->\n\n    <h2>Key Features<\/h2>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">Based on CNV analysis and SNP linkage.<\/span>\n\n        <span class=\"dlw-list-item\">Applicable to reciprocal translocations, Robertsonian translocations and inversions.<\/span>\n\n        <span class=\"dlw-list-item\">Includes the analytical content of PGT\u2011SR and adds breakpoint resolution to differentiate carrier status.<\/span>\n\n        <span class=\"dlw-list-item\">Integration with ChromGo\u00ae software for data interpretation.<\/span>\n\n        <span class=\"dlw-list-item\">Greater efficiency in each sequencing run thanks to the ability to multiplex with other Yikon product line products.<\/span>\n\n    <\/div>\n\n\n\n    <!-- Presentation Details -->\n\n    <h2>Presentation Details<\/h2>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">Library kit: XK-038 \/ XK-048<\/span>\n\n        <span class=\"dlw-list-item\">Sequencing requirements: PE, 20M\u201330M reads<\/span>\n\n    <\/div>\n\n\n\n    <!-- Modal Structure (Lightbox) -->\n\n    <div id=\"dlw-image-modal\" class=\"dlw-modal\">\n\n        <span class=\"dlw-modal-close\" onclick=\"closeDlwModal()\">&times;<\/span>\n\n        <img decoding=\"async\" class=\"dlw-modal-img\" id=\"dlw-modal-img-target\" src=\"\" alt=\"\" title=\"\">\n\n    <\/div>\n\n\n\n<\/div>\n\n\n\n<!-- Modal Script (Vanilla JS, no dependencies) -->\n\n<script>\n\n    function openDlwModal(src) {\n\n        var modal = document.getElementById('dlw-image-modal');\n\n        var modalImg = document.getElementById('dlw-modal-img-target');\n\n        modalImg.src = src;\n\n        modal.classList.add('dlw-active');\n\n        document.body.style.overflow = 'hidden';\n\n    }\n\n\n\n    function closeDlwModal() {\n\n        var modal = document.getElementById('dlw-image-modal');\n\n        modal.classList.remove('dlw-active');\n\n        document.body.style.overflow = 'auto';\n\n    }\n\n\n\n    document.getElementById('dlw-image-modal').addEventListener('click', function(e) {\n\n        if (e.target === this) {\n\n            closeDlwModal();\n\n        }\n\n    });\n\n\n\n    document.addEventListener('keydown', function(e) {\n\n        if (e.key === \"Escape\" && document.getElementById('dlw-image-modal').classList.contains('dlw-active')) {\n\n            closeDlwModal();\n\n        }\n\n    });\n\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>MaReCs\u00ae (Allelic Mapping with Resolved Carrier Status) is a PGT\u2011SR technology that first identifies aneuploid or euploid embryos and then analyses translocation breakpoints and SNP linkage to differentiate carrier from non\u2011carrier euploid embryos. Detailed Description Principle of operation MaReCs\u00ae combines ChromSwift\u00ae technology with NGS sequencing to perform a CNV analysis and subsequently an SNP linkage [&hellip;]<\/p>\n","protected":false},"featured_media":28067,"template":"","tecnologias":[36],"marcas":[237],"familias":[283,453,303],"class_list":["post-28069","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-next-generation-sequencing-ngs","marcas-yikon-genomics-en","familias-molecular-genetics","familias-preimplantation-genetic-diagnosis","familias-reproduction"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28069","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28069\/revisions"}],"predecessor-version":[{"id":28070,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28069\/revisions\/28070"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/28067"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=28069"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=28069"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=28069"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=28069"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}