{"id":28146,"date":"2026-08-24T08:14:54","date_gmt":"2026-08-24T08:14:54","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=28146"},"modified":"2026-08-24T08:43:54","modified_gmt":"2026-08-24T08:43:54","slug":"sophia-ddm-for-liquid-biopsy","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/sophia-ddm-for-liquid-biopsy\/","title":{"rendered":"SOPHiA DDM&#x2122; for Liquid Biopsy"},"content":{"rendered":"\n<!-- Scoped Styles Block -->\n<style>\n\n    @import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:ital,wght@0,400;0,700;1,400&family=Raleway:wght@300;400;500;600;700&display=swap');\n\n    \/* ==========================================\n       MAIN CONTAINER\n       ========================================== *\/\n\n    .dlw-prod-wrapper {\n        font-family: 'Raleway', sans-serif !important;\n        color: #000000 !important;\n        line-height: 1.6 !important;\n        background-color: 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}\n\n<\/style>\n\n\n<div class=\"dlw-prod-wrapper\">\n\n    <!-- PRINCIPLE OF OPERATION -->\n\n    <h2>Principle of Operation<\/h2>\n\n    <p>SOPHiA DDM&#x2122; for Liquid Biopsy comprises a set of solutions directly adapted from existing commercial applications for formalin-fixed paraffin-embedded (FFPE) tissue, enabling the analysis of circulating cell-free DNA (cfDNA) in plasma.<\/p>\n\n    <!-- Image 1 -->\n\n    <img decoding=\"async\"\n        src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/08\/Imagen1-eng.webp\"\n        alt=\"SOPHiA DDM for Liquid Biopsy\"\n        class=\"dlw-prod-img\"\n        onclick=\"openDlwModal(this.src)\"\n    >\n\n    <p>The incorporation of unique molecular identifiers (UMIs) through CUMIN&#x2122; enables the generation of ultra-deep duplex consensus sequences. This process effectively suppresses analytical sequencing noise and corrects errors accumulated during PCR amplification, ensuring reliable detection of variants at extremely low allele frequencies (with a limit of detection of up to 0.5% VAF) using a minimum input of only 20 ng of cfDNA.<\/p>\n\n    <p>This portfolio comprises 3 solutions:<\/p>\n\n\n    <!-- SOLUTIONS TABLE -->\n\n    <div class=\"dlw-table-wrapper\">\n\n        <table class=\"dlw-prod-table\">\n\n            <thead>\n                <tr>\n                    <th>Adapted Solution<\/th>\n                    <th>No. of Genes<\/th>\n                    <th>Cancer Type \/ Indications<\/th>\n                    <th>Complete List of Interrogated Genes<\/th>\n                <\/tr>\n            <\/thead>\n\n            <tbody>\n\n                <tr>\n\n                    <td>\n                        <strong>LBx STS<\/strong><br>\n                        <em>(Solid Tumor Solution)<\/em>\n                    <\/td>\n\n                    <td>\n                        <strong>42<\/strong>\n                    <\/td>\n\n                    <td>\n                        Lung cancer, melanoma, colorectal cancer, thyroid cancer, GIST and glioma in cfDNA.\n                    <\/td>\n\n                    <td>\n                        AKT1, ALK, BRAF, CDK4, CDKN2A, CTNNB1, DDR2, DICER1, EGFR, ERBB2, ERBB4, FBXW7, FGFR1, FGFR2, FGFR3, FOXL2, GNA11, GNAQ, GNAS, H3F3A, H3F3B, HIST1H3B, HRAS, IDH1, IDH2, KIT, KRAS, MAP2K1, MET, MYOD1, NRAS, PDGFRA, PIK3CA, PTPN11, RAC1, RAF1, RET, ROS1, SF3B1, SMAD4, TERT, TP53\n                    <\/td>\n\n                <\/tr>\n\n                <tr>\n\n                    <td>\n                        <strong>LBx HRS<\/strong><br>\n                        <em>(Homologous Recombination Solution)<\/em>\n                    <\/td>\n\n                    <td>\n                        <strong>16<\/strong>\n                    <\/td>\n\n                    <td>\n                        Ovarian, prostate, breast and other cancers associated with homologous recombination repair (HRR).\n                    <\/td>\n\n                    <td>\n                        ATM, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CHEK1, CHEK2, FANCL, PALB2, PPP2R2A, RAD51B, RAD51C, RAD51D, RAD54L, TP53\n                    <\/td>\n\n                <\/tr>\n\n                <tr>\n\n                    <td>\n                        <strong>LBx ExtHRS<\/strong><br>\n                        <em>(Extended HRS)<\/em>\n                    <\/td>\n\n                    <td>\n                        <strong>28<\/strong>\n                    <\/td>\n\n                    <td>\n                        Expanded profiling of genes involved in the HRR pathway (breast, ovarian and endometrial cancer).\n                    <\/td>\n\n                    <td>\n                        AKT1, ATM, BARD1, BRCA1, BRCA2, BRIP1, CCNE1, CDK12, CHEK1, CHEK2, ESR1, FANCA, FANCD2, FANCL, FGFR1, FGFR2, FGFR3, MRE11, NBN, PALB2, PIK3CA, PPP2R2A, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, TP53\n                    <\/td>\n\n                <\/tr>\n\n            <\/tbody>\n\n        <\/table>\n\n    <\/div>\n\n\n    <!-- CLINICAL APPLICATIONS -->\n\n    <h2>Clinical Applications<\/h2>\n\n    <p>This tool is intended for the non-invasive molecular profiling of solid tumors using liquid biopsy (cfDNA) in oncology research workflows and longitudinal variant monitoring.<\/p>\n\n    <p>It enables accurate assessment of tumor clonal evolution, early detection of acquired resistance mechanisms and characterization of clinically actionable biomarkers when adequate or representative tumor tissue is not available.<\/p>\n\n    <p>The portfolio specializes in translating SOPHiA GENETICS&#8217; traditional tissue applications to liquid biopsy, providing the flexibility to study the same targeted genomic regions using plasma cfDNA samples instead of difficult-to-access FFPE tissue.<\/p>\n\n\n    <!-- BENEFITS -->\n\n    <h2>Benefits<\/h2>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">Allows laboratories to retain control of their samples and data, as samples are analyzed directly in-house and combined with analysis in SOPHiA DDM&#x2122;.<\/span>\n\n        <span class=\"dlw-list-item\">Enables application customization to focus on the biomarkers of greatest interest to each laboratory.<\/span>\n\n        <span class=\"dlw-list-item\">Includes comprehensive support during application development through the SOPHiA DDM&#x2122; MaxCare program.<\/span>\n\n        <span class=\"dlw-list-item\">Incorporates proprietary CUMIN&#x2122; molecular barcoding technology for the analysis of low-frequency variants.<\/span>\n\n        <span class=\"dlw-list-item\">Enables existing SOPHiA GENETICS solid tumor applications to be adapted into equivalent liquid biopsy applications.<\/span>\n\n    <\/div>\n\n\n    <!-- INTENDED USERS -->\n\n    <h2>Intended Users<\/h2>\n\n    <p>Molecular genetics and translational oncology laboratories that already perform or wish to implement NGS-based solid tumor analysis and seek to transfer their routine tissue assays to liquid biopsy using an integrated workflow from sample to report on the SOPHiA DDM&#x2122; platform.<\/p>\n\n\n    <!-- KEY FEATURES -->\n\n    <h2>Key Features<\/h2>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">DNA-only NGS workflow, from circulating cell-free DNA to report.<\/span>\n\n        <span class=\"dlw-list-item\">Available on the SOPHiA DDM&#x2122; platform.<\/span>\n\n        <span class=\"dlw-list-item\">Applications can be customized according to biomarkers and laboratory requirements.<\/span>\n\n        <span class=\"dlw-list-item\">Combined analysis: in-house laboratory processing and cloud-based analysis.<\/span>\n\n        <span class=\"dlw-list-item\">Proprietary CUMIN&#x2122; UMI technology.<\/span>\n\n        <span class=\"dlw-list-item\">Low-frequency variant detection: 0.5% VAF from 20 ng of circulating cell-free DNA.<\/span>\n\n        <span class=\"dlw-list-item\">MSK-ACCESS\u00ae powered with SOPHiA DDM&#x2122; option with 146 genes.<\/span>\n\n        <span class=\"dlw-list-item\">Ability to adapt existing SOPHiA GENETICS solid tumor applications to liquid biopsy.<\/span>\n\n        <span class=\"dlw-list-item\">CHIP filtering available or optional depending on the solution.<\/span>\n\n        <span class=\"dlw-list-item\">Compatible with Illumina NovaSeq&#x2122; 6000 and NextSeq\u00ae\/NextSeq\u00ae 2000 platforms depending on configuration.<\/span>\n\n    <\/div>\n\n\n    <!-- PRESENTATION DETAILS -->\n\n    <h2>Presentation Details<\/h2>\n\n    <div class=\"dlw-list\">\n\n        <span class=\"dlw-list-item\">\n            <strong>Solution type:<\/strong>\n            Laboratory reagents (Universal Library Prep + specific hybridization and capture probes) + credits for bioinformatics analysis in SOPHiA DDM&#x2122;.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            <strong>Sample type:<\/strong>\n            DNA and RNA\/cDNA from FFPE, fresh or frozen tissue samples.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            <strong>Recommended sequencers:<\/strong>\n            Illumina\u00ae MiSeq\u00ae, NextSeq\u00ae 550\/1000\/2000 for the DNA+RNA workflow.\n        <\/span>\n\n    <\/div>\n\n\n    <!-- MODAL -->\n\n    <div id=\"dlw-image-modal\" class=\"dlw-modal\">\n\n        <span\n            class=\"dlw-modal-close\"\n            onclick=\"closeDlwModal()\"\n        >\u00d7<\/span>\n\n        <img decoding=\"async\"\n            class=\"dlw-modal-img\"\n            id=\"dlw-modal-img-target\"\n            src=\"\"\n            alt=\"\"\n        >\n\n    <\/div>\n\n<\/div>\n\n\n<!-- Modal Script -->\n\n<script>\n\n    function openDlwModal(src) {\n\n        var modal = document.getElementById('dlw-image-modal');\n        var modalImg = document.getElementById('dlw-modal-img-target');\n\n        modalImg.src = src;\n        modal.classList.add('dlw-active');\n        document.body.style.overflow = 'hidden';\n    }\n\n    function closeDlwModal() {\n\n        var modal = document.getElementById('dlw-image-modal');\n\n        modal.classList.remove('dlw-active');\n        document.body.style.overflow = 'auto';\n    }\n\n    document.getElementById('dlw-image-modal').addEventListener('click', function(e) {\n\n        if (e.target === this) {\n            closeDlwModal();\n        }\n    });\n\n    document.addEventListener('keydown', function(e) {\n\n        var modal = document.getElementById('dlw-image-modal');\n\n        if (\n            e.key === \"Escape\" &&\n            modal.classList.contains('dlw-active')\n        ) {\n            closeDlwModal();\n        }\n    });\n\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>Principle of Operation SOPHiA DDM&#x2122; for Liquid Biopsy comprises a set of solutions directly adapted from existing commercial applications for formalin-fixed paraffin-embedded (FFPE) tissue, enabling the analysis of circulating cell-free DNA (cfDNA) in plasma. The incorporation of unique molecular identifiers (UMIs) through CUMIN&#x2122; enables the generation of ultra-deep duplex consensus sequences. This process effectively suppresses [&hellip;]<\/p>\n","protected":false},"featured_media":28138,"template":"","tecnologias":[36],"marcas":[215],"familias":[347,465,466,459,467,468,469,464],"class_list":["post-28146","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-next-generation-sequencing-ngs","marcas-sophia-genetics-en","familias-solid-tumor","familias-digestive-system","familias-endocrine-system","familias-liquid-biopsy","familias-nervous-system","familias-reproductive-system","familias-respiratory-system","familias-tumor-types"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28146\/revisions"}],"predecessor-version":[{"id":28147,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28146\/revisions\/28147"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/28138"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=28146"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=28146"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=28146"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=28146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}