{"id":28152,"date":"2026-08-24T09:01:36","date_gmt":"2026-08-24T09:01:36","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=28152"},"modified":"2026-08-24T09:04:52","modified_gmt":"2026-08-24T09:04:52","slug":"sophia-ddm-community-liquid-biopsy-solution","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/sophia-ddm-community-liquid-biopsy-solution\/","title":{"rendered":"SOPHiA DDM&#x2122; Community Liquid Biopsy Solution"},"content":{"rendered":"\n<!-- Complete HTML ready for WordPress \/ Bricks -->\n\n<!--\nTECHNICAL REVIEW REQUIRED BEFORE PUBLICATION:\n1. The product sheet describes a solution for cfDNA from peripheral blood, but \u201cSample type\u201d is listed as FFPE.\n2. The product is described as RUO, but one product ID is labelled CE-IVD.\n3. The required materials mention genomic DNA extraction from FFPE.\n-->\n\n<style>\n.dlw-prod-wrapper {\n    --dlw-blue-dark: #003a70;\n    --dlw-blue-cyan: #00a1e0;\n    --dlw-light-bg: #f9fbfd;\n    --dlw-grey-bg: #f4f6f8;\n    --dlw-border: #e1e8f0;\n    --dlw-grey: #939598;\n    --dlw-text: #263746;\n\n    width: 100% !important;\n    max-width: 720px !important;\n    margin: 0 auto !important;\n    padding: 24px !important;\n    box-sizing: border-box !important;\n    overflow-wrap: anywhere;\n    color: var(--dlw-text);\n    font-family: \"Raleway\", Arial, sans-serif;\n    font-size: 16px;\n    line-height: 1.7;\n}\n\n.dlw-prod-wrapper *,\n.dlw-prod-wrapper *::before,\n.dlw-prod-wrapper *::after {\n    box-sizing: border-box !important;\n}\n\n.dlw-prod-wrapper h2 {\n    margin: 42px 0 20px !important;\n    padding-bottom: 10px !important;\n    border-bottom: 2px solid var(--dlw-blue-cyan) !important;\n    color: var(--dlw-blue-dark) !important;\n    font-family: \"Playfair 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!important;\n    height: 7px !important;\n    border-radius: 50% !important;\n    background: var(--dlw-blue-cyan) !important;\n    transform: translateY(-50%) !important;\n}\n\n.dlw-sublist {\n    display: flex !important;\n    flex-direction: column !important;\n    gap: 8px !important;\n    margin: 8px 0 2px 22px !important;\n}\n\n.dlw-sublist .dlw-list-item::before {\n    width: 6px !important;\n    height: 6px !important;\n    border: 1px solid var(--dlw-blue-cyan) !important;\n    background: transparent !important;\n}\n\n.dlw-spec-table {\n    width: 100% !important;\n    margin: 20px 0 28px !important;\n    border-spacing: 0 !important;\n    border-collapse: collapse !important;\n    table-layout: fixed !important;\n    font-size: 15px !important;\n}\n\n.dlw-spec-table th,\n.dlw-spec-table td {\n    padding: 14px 16px !important;\n    border: 1px solid var(--dlw-border) !important;\n    vertical-align: top !important;\n    overflow-wrap: anywhere !important;\n}\n\n.dlw-spec-table th {\n    width: 34% !important;\n    background: var(--dlw-blue-dark) !important;\n    color: #ffffff !important;\n    font-weight: 700 !important;\n    text-align: left !important;\n}\n\n.dlw-spec-table td {\n    background: #ffffff !important;\n    color: var(--dlw-text) !important;\n}\n\n.dlw-ruo-notice {\n    margin: 28px 0 !important;\n    padding: 18px 20px !important;\n    border: 2px solid var(--dlw-blue-dark) !important;\n    border-radius: 4px !important;\n    color: var(--dlw-blue-dark) !important;\n    background: var(--dlw-light-bg) !important;\n    font-weight: 700 !important;\n    text-align: center !important;\n}\n\n@media (max-width: 768px) {\n    .dlw-prod-wrapper {\n        width: 100% !important;\n        max-width: 100% !important;\n        padding: 18px 14px !important;\n        overflow-x: hidden !important;\n    }\n\n    .dlw-prod-wrapper h2 {\n        font-size: 25px !important;\n    }\n\n    .dlw-prod-wrapper h3 {\n        font-size: 20px !important;\n    }\n\n    .dlw-prod-wrapper p {\n        text-align: left !important;\n    }\n\n    .dlw-spec-table,\n    .dlw-spec-table tbody,\n    .dlw-spec-table tr,\n    .dlw-spec-table th,\n    .dlw-spec-table td {\n        display: block !important;\n        width: 100% !important;\n    }\n\n    .dlw-spec-table {\n        border: 0 !important;\n    }\n\n    .dlw-spec-table tr {\n        margin-bottom: 14px !important;\n        border: 1px solid var(--dlw-border) !important;\n        border-radius: 4px !important;\n        overflow: hidden !important;\n    }\n\n    .dlw-spec-table th {\n        border: 0 !important;\n        border-bottom: 1px solid var(--dlw-border) !important;\n    }\n\n    .dlw-spec-table td {\n        border: 0 !important;\n    }\n\n    .dlw-sublist {\n        margin-left: 10px !important;\n    }\n}\n<\/style>\n\n<div class=\"dlw-prod-wrapper\">\n\n    <h2>Principle of operation<\/h2>\n\n    <p>\n        The <strong>SOPHiA DDM&#x2122; Community Liquid Biopsy Solution 21 genes<\/strong>\n        has been developed and tested by genomic experts. The solution combines\n        a capture-based targeted enrichment kit with the advanced analytical\n        capabilities of the SOPHiA DDM&#x2122; platform, which detects, annotates and\n        pre-classifies genomic alterations in the genes included in the panel.\n    <\/p>\n\n    <p>\n        The workflow starts with cfDNA extracted from peripheral blood and requires\n        an input of more than 20 ng of cfDNA. Library preparation incorporates\n        CUMIN\u00ae molecular barcodes to support the sensitive detection of\n        low-frequency variants. The method uses hybridisation-based capture\n        enrichment and deep 20,000\u00d7 coverage in selected regions.\n    <\/p>\n\n    <h3>Gene list<\/h3>\n\n    <div class=\"dlw-gene-list\">\n        <strong>21 genes:<\/strong> AKT1, ALK, BRAF, BRCA1, BRCA2, EGFR, ERBB2,\n        ESR1, FGFR2, FGFR3, IDH1, KIT, KRAS, MET, NRAS, PALB2, PDGFRA, PIK3CA,\n        RET, ROS1 and TP53.\n    <\/div>\n\n    <h2>Clinical applications<\/h2>\n\n    <p>\n        The panel covers 21 oncogenes and tumour suppressor genes selected\n        according to ESMO recommendations and expert knowledge. It is intended\n        for research into alterations associated with multiple tumour types,\n        including breast, colorectal, prostate, non-small cell lung, thyroid,\n        melanoma, ovarian, pancreatic, gastric, cholangiocarcinoma, urothelial,\n        GIST and hepatocellular carcinoma, among others listed in the association\n        table included in the document.\n    <\/p>\n\n    <div class=\"dlw-warning-box\">\n        <strong>MSI-H:<\/strong> the solution also includes MSI-H as an indication\n        associated with immunotherapy. However, MSI status is investigational\n        and has not been verified or validated in cfDNA.\n    <\/div>\n\n    <h2>Benefits<\/h2>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">\n            The SOPHiA DDM&#x2122; platform facilitates the assessment and reporting of\n            genomic variants through algorithm-assisted variant pre-classification,\n            fully customisable filters and comprehensive report generation. These\n            functions allow users to focus the analysis on relevant genomic\n            alterations and tailor reports to their requirements.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            The optional OncoPortal&#x2122; Knowledge Base module links tumour molecular\n            profiles with clinical associations and available clinical trials,\n            using expert-curated evidence and content powered by the Genomenon\n            Cancer Knowledgebase.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            The solution is also supported by the SOPHiA GENETICS&#x2122; community,\n            where genomic experts from multiple institutions interpret findings\n            and assign pathogenicity levels to variants, securely enriching the\n            shared knowledge base for research purposes.\n        <\/span>\n    <\/div>\n\n    <h2>Intended users<\/h2>\n\n    <p>\n        This solution is intended for genomic research users and laboratories\n        working with liquid biopsy samples that require analysis of somatic\n        alterations in cfDNA, with assisted interpretation, configurable filters\n        and integrated reporting within SOPHiA DDM&#x2122;.\n    <\/p>\n\n    <p>\n        The document also highlights the support provided through the SOPHiA DDM&#x2122;\n        MaxCare Program, including assistance with assay implementation, local\n        support and access to bioinformaticians for troubleshooting workflow issues.\n    <\/p>\n\n    <h2>Considerations and limitations<\/h2>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">\n            <strong>For Research Use Only<\/strong>; not for use in diagnostic\n            procedures.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            MSI analysis is investigational and has not been verified or\n            validated in cfDNA.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            CNV detection is limited to selected genes.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            The reported sensitivity performance for SNVs and Indels is based on\n            15 real samples. Specificity, precision and accuracy are based on\n            reference materials.\n        <\/span>\n    <\/div>\n\n    <div class=\"dlw-ruo-notice\">\n        For Research Use Only. Not for use in diagnostic procedures.\n    <\/div>\n\n    <h2>Key features<\/h2>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">\n            Panel covering 21 oncogenes and tumour suppressor genes.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            Designed for cfDNA extracted from peripheral blood.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            Required input: more than 20 ng of cfDNA.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            Detection of SNVs, Indels, selected CNVs, fusions and MSI status.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            Reporting threshold for SNVs and Indels: above 0.2% VAF.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            CUMIN\u00ae molecular barcodes for sensitive detection of low-frequency\n            variants.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            Capture-based targeted enrichment with deep 20,000\u00d7 coverage in\n            selected regions.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            Library preparation and capture completed in 1.5 days when overnight\n            hybridisation is performed.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            Integration with SOPHiA DDM&#x2122; for detection, annotation,\n            pre-classification, filtering and report generation.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            Implementation support through the SOPHiA DDM&#x2122; MaxCare Program.\n        <\/span>\n    <\/div>\n\n    <h2>Product details<\/h2>\n\n    <table class=\"dlw-spec-table\">\n        <tbody>\n            <tr>\n                <th scope=\"row\">Product type<\/th>\n                <td>\n                    Bundle solution: wet-lab reagents and credits for the\n                    cloud-based SOPHiA DDM&#x2122; web platform.\n                <\/td>\n            <\/tr>\n\n            <tr>\n                <th scope=\"row\">Product ID (CE-IVD)<\/th>\n                <td>BS0121ILLCSMY08-32<\/td>\n            <\/tr>\n\n            <tr>\n                <th scope=\"row\">Product ID (RUO)<\/th>\n                <td>\n                    <div class=\"dlw-list\">\n                        <span class=\"dlw-list-item\">BS0127ILLRSMY10-16<\/span>\n                        <span class=\"dlw-list-item\">BS0127ILLRSMY10-32<\/span>\n                        <span class=\"dlw-list-item\">BS0127ILLRSMY10-48<\/span>\n                    <\/div>\n                <\/td>\n            <\/tr>\n\n            <tr>\n                <th scope=\"row\">Sample type<\/th>\n                <td>FFPE<\/td>\n            <\/tr>\n        <\/tbody>\n    <\/table>\n\n    <h3>What does the solution include?<\/h3>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">\n            SOPHiA GENETICS Universal Library Prep reagents for library\n            preparation from fragmented DNA.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            Hybridisation probes for targeted capture.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            Full access and credits for secondary and tertiary analysis on the\n            SOPHiA DDM&#x2122; platform.\n        <\/span>\n    <\/div>\n\n    <h3>Required reagents and materials not included in the kit<\/h3>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">\n            Genomic DNA extraction kits for FFPE samples.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            Equipment and reagents for fluorometric quantification and nucleic\n            acid quality control, such as Qubit&#x2122;, TapeStation&#x2122; or equivalent\n            systems.\n        <\/span>\n\n        <span class=\"dlw-list-item\">\n            Platform-specific Illumina sequencing reagents and Illumina PhiX v3\n            control.\n        <\/span>\n    <\/div>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Principle of operation The SOPHiA DDM&#x2122; Community Liquid Biopsy Solution 21 genes has been developed and tested by genomic experts. The solution combines a capture-based targeted enrichment kit with the advanced analytical capabilities of the SOPHiA DDM&#x2122; platform, which detects, annotates and pre-classifies genomic alterations in the genes included in the panel. The workflow starts [&hellip;]<\/p>\n","protected":false},"featured_media":28150,"template":"","tecnologias":[36],"marcas":[215],"familias":[347,459],"class_list":["post-28152","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-next-generation-sequencing-ngs","marcas-sophia-genetics-en","familias-solid-tumor","familias-liquid-biopsy"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28152","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28152\/revisions"}],"predecessor-version":[{"id":28153,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28152\/revisions\/28153"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/28150"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=28152"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=28152"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=28152"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=28152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}