{"id":28185,"date":"2026-08-24T09:24:58","date_gmt":"2026-08-24T09:24:58","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=28185"},"modified":"2026-08-24T09:27:55","modified_gmt":"2026-08-24T09:27:55","slug":"homologous-recombination-deficiency-hrd-solution","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/homologous-recombination-deficiency-hrd-solution\/","title":{"rendered":"Homologous Recombination Deficiency (HRD) Solution"},"content":{"rendered":"\n<!-- Complete English HTML ready for WordPress \/ Bricks -->\n<style>\n.dlw-prod-wrapper {\n    --dlw-blue-dark: #003a70;\n    --dlw-blue-cyan: #00a1e0;\n    --dlw-light-bg: #f9fbfd;\n    --dlw-grey-bg: #f4f6f8;\n    --dlw-border: #e1e8f0;\n    --dlw-grey: #939598;\n    width: 100% !important;\n    max-width: 720px !important;\n    margin: 0 auto !important;\n    padding: 20px !important;\n    box-sizing: border-box !important;\n    overflow-wrap: anywhere;\n    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font-size: 24px !important;\n    }\n\n    .dlw-prod-wrapper h3 {\n        font-size: 20px !important;\n    }\n\n    .dlw-prod-wrapper p {\n        text-align: left;\n    }\n\n    .dlw-prod-img {\n        max-width: 100% !important;\n    }\n\n    .dlw-spec-table,\n    .dlw-spec-table tbody,\n    .dlw-spec-table tr,\n    .dlw-spec-table th,\n    .dlw-spec-table td {\n        display: block;\n        width: 100% !important;\n    }\n\n    .dlw-spec-table {\n        border: 0 !important;\n    }\n\n    .dlw-spec-table tr {\n        margin-bottom: 14px;\n        border: 1px solid var(--dlw-border);\n        border-radius: 7px;\n        overflow: hidden;\n    }\n\n    .dlw-spec-table th,\n    .dlw-spec-table td {\n        border: 0 !important;\n    }\n\n    .dlw-spec-table th {\n        padding-bottom: 8px !important;\n    }\n\n    .dlw-spec-table td {\n        padding-top: 10px !important;\n    }\n}\n<\/style>\n\n<div class=\"dlw-prod-wrapper\">\n\n    <h2>Homologous Recombination Deficiency (HRD) Solution<\/h2>\n\n    <div class=\"dlw-prod-highlight\">\n        NGS- and low-pass whole-genome sequencing (low-pass WGS)-based solution for determining homologous recombination deficiency (HRD) status in ovarian cancer.\n    <\/div>\n\n    <h2>Operating Principle<\/h2>\n\n    <p>\n        This comprehensive solution, available as CE-IVD and for Research Use Only (RUO), is designed to support the determination of tumour HRD status in patients with ovarian cancer.\n    <\/p>\n\n    <div class=\"dlw-prod-img-wrap\">\n        <img decoding=\"async\"\n            src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/08\/1-eng-1.webp\"\n            alt=\"Homologous Recombination Deficiency Solution workflow\"\n            class=\"dlw-prod-img\"\n            onclick=\"openDlwModal(this.src)\"\n        >\n    <\/div>\n\n    <p>\n        It integrates two complementary biological components: evaluation of alterations in 28 genes involved in the homologous recombination repair (HRR) pathway, including <strong>BRCA1<\/strong> and <strong>BRCA2<\/strong>, and assessment of genomic instability (GI) based on low-coverage whole-genome profiles.\n    <\/p>\n\n    <p>\n        The workflow combines targeted capture and low-pass WGS using DNA extracted from FFPE tissue and a universal library preparation method (Universal Library Prep).\n    <\/p>\n\n    <div class=\"dlw-prod-img-wrap\">\n        <img decoding=\"async\"\n            src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/08\/Imagen-2.webp\"\n            alt=\"Library preparation and low-pass WGS workflow\"\n            class=\"dlw-prod-img\"\n            onclick=\"openDlwModal(this.src)\"\n        >\n    <\/div>\n\n    <p>\n        Bioinformatic analysis is performed on the decentralised SOPHiA DDM&#x2122; platform. Genomic profiles are analysed using GIInger&#x2122;, a deep-learning algorithm trained to recognise genomic signatures characteristic of tumours with alterations in DNA repair mechanisms.\n    <\/p>\n\n    <p>\n        Based on these patterns, the system classifies the sample as HRD-positive or HRD-negative. At the same time, analysis of the 28-gene panel\u2014provided as clinical decision support (CDS)\u2014enables the detection of SNVs, Indels, amplifications such as the <strong>CCNE1<\/strong> biomarker, whole-gene deletions, and gene- and exon-level CNVs.\n    <\/p>\n\n    <div class=\"dlw-prod-img-wrap\">\n        <img decoding=\"async\"\n            src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/08\/3-eng.webp\"\n            alt=\"GIInger genomic instability analysis\"\n            class=\"dlw-prod-img\"\n            onclick=\"openDlwModal(this.src)\"\n        >\n    <\/div>\n\n    <p>\n        The combined result supports the molecular characterisation of ovarian tumours and may help guide therapeutic decision-making, including the assessment of potential benefit from PARP inhibitor treatment.\n    <\/p>\n\n    <div class=\"dlw-prod-img-wrap\">\n        <img decoding=\"async\"\n            src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/08\/4-eng.webp\"\n            alt=\"HRD result interpretation\"\n            class=\"dlw-prod-img\"\n            onclick=\"openDlwModal(this.src)\"\n        >\n    <\/div>\n\n    <h2>Benefits<\/h2>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Decentralised solution that allows laboratories to perform the analysis locally.<\/span>\n        <span class=\"dlw-list-item\">Reliable, automated assessment of HRD status, reducing interpretation bias.<\/span>\n        <span class=\"dlw-list-item\">Intuitive web-based platform, SOPHiA DDM&#x2122;, for rapid data upload, analysis and result review.<\/span>\n        <span class=\"dlw-list-item\">Reduced hands-on time through an optimised and automatable workflow.<\/span>\n        <span class=\"dlw-list-item\">Secure, unlimited cloud data storage, eliminating the need for additional local IT infrastructure.<\/span>\n        <span class=\"dlw-list-item\">Rapid generation of clear and interpretable clinical reports.<\/span>\n        <span class=\"dlw-list-item\">Specialised technical and bioinformatic support to ensure successful implementation and routine operation.<\/span>\n    <\/div>\n\n    <h2>Intended Audience\/User<\/h2>\n\n    <p>\n        Clinical genetics and molecular oncology laboratories involved in the diagnosis, management and therapeutic decision-making of patients with ovarian cancer.\n    <\/p>\n\n    <h2>Additional Considerations<\/h2>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Validated for DNA obtained from ovarian cancer samples.<\/span>\n        <span class=\"dlw-list-item\">Analytical performance was verified using Illumina\u00ae NextSeq\u00ae 500\/550 sequencers. Although the solution is compatible with data generated on NovaSeq&#x2122; X, analytical validation was performed using NextSeq\u00ae 500\/550.<\/span>\n        <span class=\"dlw-list-item\">The quality of the HRD result depends on parameters such as coverage, tumour content and DNA quality.<\/span>\n        <span class=\"dlw-list-item\">Samples with a low signal-to-noise ratio, low coverage or insufficient tumour content may produce inconclusive or indeterminate results.<\/span>\n        <span class=\"dlw-list-item\"><em>GI Negative<\/em> results represent intermediate-confidence negative calls associated with a higher risk of false-negative results, generally due to low tumour content.<\/span>\n        <span class=\"dlw-list-item\">The solution enables evaluation of <strong>CCNE1<\/strong> gene amplifications, a biomarker that may support the biological interpretation of HRD-negative tumours. The system calculates the gene copy number and considers a gene amplified when its estimated copy number is greater than 3.25.<\/span>\n        <span class=\"dlw-list-item\">Gene-panel analysis is provided as clinical decision support (CDS) and is not included in the product\u2019s CE-IVD claim.<\/span>\n        <span class=\"dlw-list-item\">Analysis time may vary depending on the number of samples processed simultaneously and the system workload.<\/span>\n        <span class=\"dlw-list-item\">Regulatory availability depends on the country or region.<\/span>\n    <\/div>\n\n    <h2>Key Features<\/h2>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Minimum input requirement of 50 ng of DNA from ovarian tumour tissue (FFPE).<\/span>\n        <span class=\"dlw-list-item\">Overall concordance of 94.4% compared with comparator NGS assays, with analytical repeatability and reproducibility of 100%.<\/span>\n        <span class=\"dlw-list-item\">Automatic quality-control metrics for performance monitoring: panel coverage &gt;100\u00d7, <strong>BRCA1\/BRCA2<\/strong> coverage &gt;100\u00d7 and BRCA coverage uniformity.<\/span>\n        <span class=\"dlw-list-item\">Very rapid bioinformatic analysis: &lt;8 hours from receipt of the FASTQ files.<\/span>\n        <span class=\"dlw-list-item\">Approximate end-to-end workflow from sample extraction to final report: 3.5 days.<\/span>\n        <span class=\"dlw-list-item\">Analytical compatibility verified with Illumina\u00ae NextSeq\u00ae 500\/550 and Illumina\u00ae 1k\/2k sequencers; also compatible with data generated on NovaSeq&#x2122; X.<\/span>\n        <span class=\"dlw-list-item\">Automatable protocol using liquid-handling systems such as Hamilton\u00ae NGS STAR and Hamilton\u00ae Clinical STARlet.<\/span>\n        <span class=\"dlw-list-item\">Officially recognised by ESMO as a validated method for HRD detection.<\/span>\n    <\/div>\n\n    <h2>Presentation Details<\/h2>\n\n    <div class=\"dlw-table-wrap\">\n        <table class=\"dlw-spec-table\">\n            <tbody>\n                <tr>\n                    <th>Commercial name<\/th>\n                    <td>Homologous Recombination Deficiency (HRD) Solution<\/td>\n                <\/tr>\n                <tr>\n                    <th>Product ID (CE-IVD)<\/th>\n                    <td>BS0121ILLCSMY08-32<\/td>\n                <\/tr>\n                <tr>\n                    <th>Product IDs (RUO)<\/th>\n                    <td>\n                        BS0127ILLRSMY10-16<br>\n                        BS0127ILLRSMY10-32<br>\n                        BS0127ILLRSMY10-48\n                    <\/td>\n                <\/tr>\n                <tr>\n                    <th>Sample type<\/th>\n                    <td>DNA extracted from formalin-fixed, paraffin-embedded tumour tissue (FFPE).<\/td>\n                <\/tr>\n            <\/tbody>\n        <\/table>\n    <\/div>\n\n    <h3>What does the solution include?<\/h3>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">SOPHiA GENETICS Universal Library Prep reagents for fragmented DNA library preparation.<\/span>\n        <span class=\"dlw-list-item\">Hybridisation and targeted-capture probes.<\/span>\n        <span class=\"dlw-list-item\">Full access and credits for secondary and tertiary analysis on the SOPHiA DDM&#x2122; platform.<\/span>\n    <\/div>\n\n    <h3>Required reagents and materials not included in the kit<\/h3>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">FFPE DNA extraction kits.<\/span>\n        <span class=\"dlw-list-item\">Equipment and reagents for fluorometric quantification and nucleic-acid quality control, such as Qubit&#x2122;, TapeStation&#x2122; or equivalent.<\/span>\n        <span class=\"dlw-list-item\">Platform-specific Illumina sequencing reagents and Illumina PhiX v3 control.<\/span>\n    <\/div>\n\n    <div class=\"dlw-note\">\n        Product availability and regulatory status may vary by country or region. The gene-panel analysis is provided as clinical decision support and is not part of the product\u2019s CE-IVD claim.\n    <\/div>\n\n<\/div>\n\n<div\n    id=\"dlwImageModal\"\n    class=\"dlw-modal\"\n    role=\"dialog\"\n    aria-modal=\"true\"\n    aria-label=\"Enlarged product image\"\n    onclick=\"closeDlwModalOnBackdrop(event)\"\n>\n    <button\n        type=\"button\"\n        class=\"dlw-modal-close\"\n        aria-label=\"Close image\"\n        onclick=\"closeDlwModal()\"\n    >&times;<\/button>\n    <img decoding=\"async\" id=\"dlwModalImage\" class=\"dlw-modal-content\" src=\"\" alt=\"Enlarged product image\" title=\"\">\n<\/div>\n\n<script>\n(function () {\n    var modal = document.getElementById(\"dlwImageModal\");\n    var modalImage = document.getElementById(\"dlwModalImage\");\n\n    window.openDlwModal = function (src) {\n        if (!modal || !modalImage) return;\n        modalImage.src = src;\n        modal.classList.add(\"dlw-modal-open\");\n        document.body.style.overflow = \"hidden\";\n    };\n\n    window.closeDlwModal = function () {\n        if (!modal || !modalImage) return;\n        modal.classList.remove(\"dlw-modal-open\");\n        modalImage.src = \"\";\n        document.body.style.overflow = \"\";\n    };\n\n    window.closeDlwModalOnBackdrop = function (event) {\n        if (event.target === modal) {\n            window.closeDlwModal();\n        }\n    };\n\n    document.addEventListener(\"keydown\", function (event) {\n        if (event.key === \"Escape\" && modal &&\n            modal.classList.contains(\"dlw-modal-open\")) {\n            window.closeDlwModal();\n        }\n    });\n})();\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>Homologous Recombination Deficiency (HRD) Solution NGS- and low-pass whole-genome sequencing (low-pass WGS)-based solution for determining homologous recombination deficiency (HRD) status in ovarian cancer. Operating Principle This comprehensive solution, available as CE-IVD and for Research Use Only (RUO), is designed to support the determination of tumour HRD status in patients with ovarian cancer. It integrates two [&hellip;]<\/p>\n","protected":false},"featured_media":28174,"template":"","tecnologias":[36],"marcas":[215],"familias":[347,461,468],"class_list":["post-28185","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-next-generation-sequencing-ngs","marcas-sophia-genetics-en","familias-solid-tumor","familias-hrd-en","familias-reproductive-system"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28185","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28185\/revisions"}],"predecessor-version":[{"id":28186,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28185\/revisions\/28186"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/28174"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=28185"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=28185"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=28185"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=28185"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}