{"id":28321,"date":"2026-09-01T06:54:36","date_gmt":"2026-09-01T06:54:36","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=28321"},"modified":"2026-09-01T06:58:10","modified_gmt":"2026-09-01T06:58:10","slug":"franklin-by-qiagen-for-somatic-analysis","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/franklin-by-qiagen-for-somatic-analysis\/","title":{"rendered":"Franklin by QIAGEN for Somatic Analysis"},"content":{"rendered":"\n<!-- Complete HTML ready for WordPress \/ Bricks -->\n<style>\n.dlw-prod-wrapper {\n    --dlw-blue-dark: #003a70;\n    --dlw-blue-cyan: #00a1e0;\n    --dlw-light-bg: #f9fbfd;\n    --dlw-grey-bg: #f4f6f8;\n    --dlw-border: #e1e8f0;\n    --dlw-grey: #939598;\n\n    width: 100% !important;\n    max-width: 720px !important;\n    margin: 0 auto !important;\n    padding: 24px !important;\n    box-sizing: border-box !important;\n    overflow-wrap: anywhere;\n    color: #263746;\n    background: 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.dlw-prod-wrapper .dlw-section-title {\n        font-size: 26px !important;\n    }\n\n    .dlw-prod-wrapper .dlw-subtitle {\n        font-size: 21px !important;\n    }\n\n    .dlw-prod-wrapper .dlw-text {\n        text-align: left;\n    }\n\n    .dlw-prod-wrapper .dlw-prod-img {\n        width: auto !important;\n        max-width: 100% !important;\n    }\n\n    .dlw-modal {\n        padding: 15px;\n    }\n\n    .dlw-modal-close {\n        top: 8px;\n        right: 14px;\n    }\n}\n<\/style>\n\n<div class=\"dlw-prod-wrapper\">\n    <p class=\"dlw-intro\">\n        Advanced cloud-based bioinformatics platform designed for the automated analysis, interpretation, and classification of somatic variants in oncology. Through an integrated environment, the system evaluates clinical evidence in real time, automates classification in accordance with AMP\/ASCO\/CAP guidelines, and provides access to currently active clinical trials.\n    <\/p>\n\n    <div class=\"dlw-image-wrap\">\n        <img decoding=\"async\"\n            src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/09\/1-1.webp\"\n            alt=\"Bioinformatics platform for the analysis and interpretation of somatic variants\"\n            class=\"dlw-prod-img\"\n            onclick=\"openDlwModal(this.src, this.alt)\"\n        >\n    <\/div>\n\n    <h2 class=\"dlw-section-title\">Detailed description<\/h2>\n\n    <h3 class=\"dlw-subtitle\">Operating principle<\/h3>\n\n    <p class=\"dlw-text\">\n        End-to-end cloud-based solution for the clinical interpretation of NGS data focused on somatic variants. The system stands out for its flexibility, allowing direct processing of FASTQ files (generated during the run following library preparation) or VCF files, compatible with panels based on different primers for solid tumors and oncohematology.\n    <\/p>\n\n    <p class=\"dlw-text\">\n        To activate the oncology workflow, the user switches to <strong>\u201cSomatic\u201d<\/strong> mode. The core of this classification lies in the clinical context: the specific cancer type is a critical parameter used by the algorithm to dynamically calculate the hierarchy of therapeutic evidence levels under the AMP Tier system.\n    <\/p>\n\n    <p class=\"dlw-text\">\n        Once the data have been analyzed, the system centralizes the information in the <strong>Variant Exploration Hub<\/strong>. The platform cross-references the identified variants with public databases, expert-curated medical literature, and a real-time community network, structuring the evidence across four dimensions: therapeutic, diagnostic, prognostic, and predisposing.\n    <\/p>\n\n    <div class=\"dlw-image-wrap\">\n        <img decoding=\"async\"\n            src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/09\/2en.webp\"\n            alt=\"Clinical evidence visualization for somatic variants\"\n            class=\"dlw-prod-img\"\n            onclick=\"openDlwModal(this.src, this.alt)\"\n        >\n    <\/div>\n\n    <h3 class=\"dlw-subtitle\">Clinical applications<\/h3>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Interpretation of somatic variants in oncology research.<\/span>\n        <span class=\"dlw-list-item\">Centralized review of therapeutic, diagnostic, and prognostic evidence.<\/span>\n        <span class=\"dlw-list-item\">Access to clinical trials relevant to the alteration being analyzed.<\/span>\n    <\/div>\n\n    <h3 class=\"dlw-subtitle\">Benefits<\/h3>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Proprietary algorithms for variant calling (SNV, CNV, Indel) and TMB calculation.<\/span>\n        <span class=\"dlw-list-item\">Clinical interpretation and visualization module for external genomic signatures (HRD, MSI).<\/span>\n        <span class=\"dlw-list-item\">Clinical trials can be filtered by phase, location, status, and date, improving the exploration of relevant research options.<\/span>\n        <span class=\"dlw-list-item\">Classification of somatic variants in accordance with AMP guidelines.<\/span>\n        <span class=\"dlw-list-item\">Therapeutic, diagnostic, prognostic, and predisposing evidence, with the level calculated according to the available evidence and the cancer type of the case.<\/span>\n        <span class=\"dlw-list-item\">Evidence coverage ranging from the gene level to the specific variant level.<\/span>\n        <span class=\"dlw-list-item\">List of relevant clinical trials.<\/span>\n        <span class=\"dlw-list-item\">Additional annotations in the variant assessment tab, such as COSMIC frequency.<\/span>\n    <\/div>\n\n    <h3 class=\"dlw-subtitle\">Technology used<\/h3>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Cloud-based bioinformatics platform with a dedicated mode for somatic analysis.<\/span>\n        <span class=\"dlw-list-item\">Integration of evidence from sources such as FDA-approved drugs, NCCN guidelines, CIViC, ClinicalTrials.org, and curated literature.<\/span>\n        <span class=\"dlw-list-item\">AMP-based somatic classification engine.<\/span>\n        <span class=\"dlw-list-item\">Proprietary algorithms for variant calling (SNV, CNV, Indel) and TMB calculation.<\/span>\n        <span class=\"dlw-list-item\">Clinical interpretation and visualization module for external genomic signatures (HRD, MSI).<\/span>\n    <\/div>\n\n    <h3 class=\"dlw-subtitle\">Intended audience\/users<\/h3>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Laboratories, hospitals, and organizations specializing in genetic analysis and interpretation for research purposes.<\/span>\n        <span class=\"dlw-list-item\">Users with advanced expertise in genetics and variant analysis.<\/span>\n    <\/div>\n\n    <h3 class=\"dlw-subtitle\">Key aspects<\/h3>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">Classification dependent on tumor context.<\/span>\n        <span class=\"dlw-list-item\">Advanced clinical trial filters by phase, location, and status.<\/span>\n        <span class=\"dlw-list-item\">Clear additional annotations (e.g., COSMIC frequencies) and separation between genomic signature calculation and interpretation.<\/span>\n    <\/div>\n<\/div>\n\n<div\n    id=\"dlwImageModal\"\n    class=\"dlw-modal\"\n    role=\"dialog\"\n    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and classification of somatic variants in oncology. Through an integrated environment, the system evaluates clinical evidence in real time, automates classification in accordance with AMP\/ASCO\/CAP guidelines, and provides access to currently active clinical trials. Detailed description Operating principle End-to-end cloud-based solution for the clinical interpretation [&hellip;]<\/p>\n","protected":false},"featured_media":28313,"template":"","tecnologias":[36],"marcas":[244],"familias":[456,490],"class_list":["post-28321","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-next-generation-sequencing-ngs","marcas-verogen-en","familias-software-en","familias-software-en-2"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28321","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28321\/revisions"}],"predecessor-version":[{"id":28322,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28321\/revisions\/28322"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/28313"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=28321"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=28321"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=28321"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=28321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}