{"id":28524,"date":"2026-10-06T11:43:46","date_gmt":"2026-10-06T11:43:46","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=28524"},"modified":"2026-10-06T11:46:17","modified_gmt":"2026-10-06T11:46:17","slug":"genvinset-pai-1-fxiii-multiplex","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/genvinset-pai-1-fxiii-multiplex\/","title":{"rendered":"Genvinset\u00ae PAI-1\/FXIII multiplex"},"content":{"rendered":"\n<!-- Complete HTML ready for WordPress \/ Bricks -->\n\n<style>\n@import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:wght@500;600&family=Raleway:wght@400;500;600;700&display=swap');\n\n#dlw-pai-fxiii-en,\n#dlw-pai-fxiii-en *,\n#dlw-pai-fxiii-en *::before,\n#dlw-pai-fxiii-en *::after {\n    box-sizing: border-box !important;\n}\n\n#dlw-pai-fxiii-en {\n    --dlw-blue-dark: #003a70;\n    --dlw-blue-cyan: #00a1e0;\n    --dlw-light-bg: #f9fbfd;\n    --dlw-grey-bg: #f4f6f8;\n    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   font-size: 15px !important;\n    }\n\n    #dlw-pai-fxiii-en p,\n    #dlw-pai-fxiii-en .dlw-intro p {\n        font-size: 15px !important;\n        text-align: left !important;\n    }\n\n    #dlw-pai-fxiii-en .dlw-intro {\n        padding: 21px !important;\n    }\n\n    #dlw-pai-fxiii-en h2 {\n        font-size: 25px !important;\n    }\n\n    #dlw-pai-fxiii-en h3 {\n        font-size: 19px !important;\n    }\n\n    #dlw-pai-fxiii-en .dlw-list-item {\n        font-size: 15px !important;\n    }\n\n    #dlw-pai-fxiii-en .dlw-key-panel {\n        padding: 25px 21px !important;\n    }\n\n    #dlw-pai-fxiii-en .dlw-key-grid {\n        grid-template-columns: minmax(0, 1fr) !important;\n        gap: 21px !important;\n    }\n\n    #dlw-pai-fxiii-en .dlw-indicators {\n        grid-template-columns: minmax(0, 1fr) !important;\n    }\n\n    #dlw-pai-fxiii-en .dlw-indicator {\n        min-height: 112px !important;\n    }\n\n    #dlw-pai-fxiii-en .dlw-reference-grid {\n        grid-template-columns: minmax(0, 1fr) !important;\n    }\n\n    #dlw-pai-fxiii-en .dlw-reference-card {\n        min-height: 0 !important;\n    }\n\n    #dlw-pai-fxiii-en .dlw-details > summary {\n        padding: 19px 58px 19px 20px !important;\n        font-size: 20px !important;\n    }\n\n    #dlw-pai-fxiii-en .dlw-details-content {\n        padding: 23px 19px 25px !important;\n    }\n}\n<\/style>\n\n<div id=\"dlw-pai-fxiii-en\" class=\"dlw-prod-wrapper\">\n\n    <div class=\"dlw-intro\">\n        <p><em>In vitro<\/em> diagnostic kit based on real-time PCR for the simultaneous detection of the -675 PAI-1 4G\/5G polymorphism in the SERPINE1 gene and rs5985 (Val34Leu) in the F13A1 gene, associated with the risk of thrombosis.<\/p>\n    <\/div>\n\n    <h2>Detailed description<\/h2>\n\n    <h3>Operating principle<\/h3>\n\n    <p>Genvinset\u00ae PAI-1\/FXIII multiplex uses real-time PCR technology (Real-Time PCR) with TaqMan\u00ae hydrolysis probes for the qualitative detection of the -675 PAI-1 4G\/5G polymorphism (rs1799762) in the SERPINE1 gene and rs5985 (Val34Leu) in the F13A1 gene.<\/p>\n\n    <p>The assay uses specific primers and fluorescent probes labelled with HEX, FAM, Cy5 and ROX to discriminate between wild-type and mutant alleles. The fluorescent signal generated during amplification enables the identification of homozygous and heterozygous genotypes through curve analysis and allelic discrimination.<\/p>\n\n    <h3>Clinical applications<\/h3>\n\n    <p>The kit is designed to assist in the evaluation of patients with suspected inherited thrombophilia or thromboembolic predisposition. The variants analysed are associated with deep vein thrombosis (DVT), venous thromboembolism (VTE), and alterations in fibrinolysis and coagulation.<\/p>\n\n    <h2>Key aspects and benefits<\/h2>\n\n    <div class=\"dlw-key-panel\">\n        <div class=\"dlw-key-grid\">\n            <div class=\"dlw-key-item\">Simultaneous detection of the PAI-1 4G\/5G and FXIII Val34Leu polymorphisms in a single multiplex reaction.<\/div>\n            <div class=\"dlw-key-item\">Compatible with multiple real-time PCR platforms.<\/div>\n            <div class=\"dlw-key-item\">Compatible with automated pipetting systems.<\/div>\n            <div class=\"dlw-key-item\">High sensitivity and specificity.<\/div>\n        <\/div>\n    <\/div>\n\n    <h3>Key indicators<\/h3>\n\n    <div class=\"dlw-indicators\">\n        <div class=\"dlw-indicator\">\n            <span class=\"dlw-indicator-value\">100%<\/span>\n            <span class=\"dlw-indicator-label\">Diagnostic concordance compared with alternative methods.<\/span>\n        <\/div>\n\n        <div class=\"dlw-indicator\">\n            <span class=\"dlw-indicator-value\">100%<\/span>\n            <span class=\"dlw-indicator-label\">Repeatability.<\/span>\n        <\/div>\n\n        <div class=\"dlw-indicator\">\n            <span class=\"dlw-indicator-value\">100%<\/span>\n            <span class=\"dlw-indicator-label\">Reproducibility.<\/span>\n        <\/div>\n    <\/div>\n\n    <h3>Intended users<\/h3>\n\n    <p>Technical personnel trained and qualified in molecular biology and genetic analysis in specialised clinical laboratories.<\/p>\n\n    <h3>Considerations or limitations<\/h3>\n\n    <div class=\"dlw-list\">\n        <span class=\"dlw-list-item\">The assay exclusively detects the -675 PAI-1 4G\/5G and rs5985 polymorphisms.<\/span>\n        <span class=\"dlw-list-item\">Variants in primer- or probe-binding regions may affect the interpretation of results.<\/span>\n        <span class=\"dlw-list-item\">The results must be used together with other clinical and laboratory data.<\/span>\n    <\/div>\n\n    <details class=\"dlw-details\">\n        <summary>Presentation details<\/summary>\n\n        <div class=\"dlw-details-content\">\n            <span class=\"dlw-details-heading\">Available references<\/span>\n\n            <div class=\"dlw-reference-grid\">\n                <div class=\"dlw-reference-card\">\n                    <span class=\"dlw-reference-code\">GVS-PAI\/F13-24<\/span>\n                    <span class=\"dlw-reference-tests\">24 tests.<\/span>\n                <\/div>\n\n                <div class=\"dlw-reference-card\">\n                    <span class=\"dlw-reference-code\">GVS-PAI\/F13-48<\/span>\n                    <span class=\"dlw-reference-tests\">48 tests.<\/span>\n                <\/div>\n\n                <div class=\"dlw-reference-card\">\n                    <span class=\"dlw-reference-code\">GVS-PAI\/F13-96<\/span>\n                    <span class=\"dlw-reference-tests\">96 tests (on request).<\/span>\n                <\/div>\n            <\/div>\n\n            <div class=\"dlw-detail-row\">\n                <strong>Kit contents:<\/strong> each kit contains Master Mix, the primer mixture (Primer Mix), controls (WT and MUT), and a reaction blank (Reaction Blank).\n            <\/div>\n\n            <div class=\"dlw-detail-row\">\n                <strong>Storage conditions:<\/strong> Store between -30\u00b0C and -18\u00b0C.\n            <\/div>\n        <\/div>\n    <\/details>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>In vitro diagnostic kit based on real-time PCR for the simultaneous detection of the -675 PAI-1 4G\/5G polymorphism in the SERPINE1 gene and rs5985 (Val34Leu) in the F13A1 gene, associated with the risk of thrombosis. Detailed description Operating principle Genvinset\u00ae PAI-1\/FXIII multiplex uses real-time PCR technology (Real-Time PCR) with TaqMan\u00ae hydrolysis probes for the qualitative [&hellip;]<\/p>\n","protected":false},"featured_media":28522,"template":"","tecnologias":[275],"marcas":[225],"familias":[307],"class_list":["post-28524","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-rt-pcr-en","marcas-blackhills-diagnostic-resources-en","familias-hematology-and-blood-bank"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28524\/revisions"}],"predecessor-version":[{"id":28525,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28524\/revisions\/28525"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/28522"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=28524"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=28524"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=28524"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=28524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}