{"id":28598,"date":"2026-10-15T06:25:25","date_gmt":"2026-10-15T06:25:25","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=28598"},"modified":"2026-10-15T06:34:24","modified_gmt":"2026-10-15T06:34:24","slug":"beacon-optofluidic-suite","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/beacon-optofluidic-suite\/","title":{"rendered":"Beacon\u00ae Optofluidic Suite"},"content":{"rendered":"\n<!-- Complete HTML ready for WordPress \/ Bricks -->\n\n<style>\n    #dlw-beacon-suite-en,\n    #dlw-beacon-suite-en *,\n    #dlw-beacon-suite-en *::before,\n    #dlw-beacon-suite-en *::after {\n        box-sizing: border-box !important;\n    }\n\n    #dlw-beacon-suite-en {\n        --dlw-blue-dark: #003a70;\n        --dlw-blue-cyan: #00a1e0;\n        --dlw-blue-soft: #eaf6fb;\n        --dlw-light-bg: #f9fbfd;\n        --dlw-grey-bg: #f4f6f8;\n        --dlw-border: #d5e1eb;\n        width: 100% !important;\n        max-width: 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      }\n\n        #dlw-beacon-suite-en .dlw-spec-table tbody td,\n        #dlw-beacon-suite-en .dlw-spec-table tbody tr:nth-child(even) td:not(:first-child) {\n            padding: 15px 17px !important;\n            border: 0 !important;\n            border-bottom: 1px solid var(--dlw-border) !important;\n            background: #ffffff !important;\n            font-size: 14px !important;\n        }\n\n        #dlw-beacon-suite-en .dlw-spec-table tbody td:first-child {\n            background: var(--dlw-blue-soft) !important;\n        }\n\n        #dlw-beacon-suite-en .dlw-spec-table tbody td:last-child {\n            border-bottom: 0 !important;\n        }\n\n        #dlw-beacon-suite-en .dlw-spec-table td::before {\n            content: attr(data-label) !important;\n            display: block !important;\n            margin-bottom: 5px !important;\n            color: var(--dlw-blue-cyan) !important;\n            font-size: 12px !important;\n            font-weight: 700 !important;\n            line-height: 1.3 !important;\n            letter-spacing: 0.04em !important;\n            text-transform: uppercase !important;\n        }\n\n        #dlw-beacon-suite-en .dlw-cta {\n            width: 100% !important;\n        }\n\n        #dlw-beacon-modal-en {\n            padding: 16px !important;\n        }\n    }\n\n    @media (prefers-reduced-motion: reduce) {\n        #dlw-beacon-suite-en .dlw-app-img,\n        #dlw-beacon-suite-en .dlw-cta {\n            transition: none !important;\n        }\n    }\n<\/style>\n\n<div id=\"dlw-beacon-suite-en\" class=\"dlw-prod-wrapper\">\n\n    <p class=\"dlw-lead\">\n        The Beacon\u00ae Optofluidic Suite represents an absolute revolution in cell biology and biotherapeutic development. By synergistically integrating advanced microfluidics, precision optics, optoelectronics and artificial intelligence, this platform enables the isolation, culture, characterization and recovery of thousands of individual cells in a fully automated manner and in real time.\n    <\/p>\n\n    <p>\n        Unlike traditional static or destructive methodologies, Bruker\u2019s optoelectronic force (OEP) technology manipulates cells extremely gently using light, enabling multiple functional and kinetic parameters to be assessed in living cells and, subsequently, the highest-value clones to be recovered for subsequent sequencing or clonal expansion.\n    <\/p>\n\n    <div class=\"dlw-video-block\">\n        <div class=\"dlw-video-frame\">\n            <iframe\n                src=\"https:\/\/player.vimeo.com\/video\/1236101157?h=acfdb321bf&amp;badge=0&amp;autopause=0&amp;player_id=0&amp;app_id=58479\"\n                title=\"Beacon\u00ae Optofluidic Suite1\"\n                frameborder=\"0\"\n                allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\"\n                referrerpolicy=\"strict-origin-when-cross-origin\"\n                loading=\"lazy\"\n                allowfullscreen\n            ><\/iframe>\n        <\/div>\n    <\/div>\n\n    <h2>Key features<\/h2>\n\n    <div class=\"dlw-feature-panel\">\n        <div class=\"dlw-feature-item\">\n            <strong>Advanced optofluidic manipulation using OEP:<\/strong> Uses non-invasive structured light patterns to precisely move individual cells into nanoPen\u00ae microassay chambers.\n        <\/div>\n\n        <div class=\"dlw-feature-item\">\n            <strong>Real-time multimodal monitoring:<\/strong> Automates the acquisition of brightfield and multichannel fluorescence images to monitor viability, proliferation, cell-cell interaction and molecular secretion over time.\n        <\/div>\n\n        <div class=\"dlw-feature-item\">\n            <strong>nanoPen\u00ae microassay chambers:<\/strong> Patented microfluidic chips that confine cells in nanoliter volumes, enabling rapid enrichment of secreted signals and ultrasensitive phenotypic characterization.\n        <\/div>\n\n        <div class=\"dlw-feature-item\">\n            <strong>Automated recovery of high-value cells:<\/strong> Selects and exports individual cells or specific clones detected in direct functional assays with 100% accuracy into PCR plates or culture wells, seamlessly linking the live functional phenotype with genomics and transcriptomics (TCR-seq, BCR-seq, mRNA-seq).\n        <\/div>\n\n        <div class=\"dlw-feature-item\">\n            <strong>Highly accelerated workflows:<\/strong> Dramatically reduces traditional hybridoma screening or B-cell screening campaigns from months to just a few days, maximizing operational efficiency.\n        <\/div>\n    <\/div>\n\n    <h2>How does Beacon\u00ae work?<\/h2>\n\n    <p class=\"dlw-workflow-intro\">\n        The Beacon\u00ae system redefines the study of cellular heterogeneity through a simplified, closed and automated workflow comprising four critical stages:\n    <\/p>\n\n    <div class=\"dlw-step\">\n        <div class=\"dlw-step-heading\">\n            <span class=\"dlw-step-number\">1<\/span>\n            <h3>Cell loading and import<\/h3>\n        <\/div>\n\n        <p>\n            The cell suspension is automatically introduced into the main fluidic channels of the OptoSelect\u00ae chip. Using light directed by the optoelectronic system, thousands of individual cells are gently guided into the NanoPen\u00ae microchambers, where they remain physically isolated while maintaining constant diffusive exchange with the continuous perfusion medium.\n        <\/p>\n\n        <div class=\"dlw-video-block\">\n            <div class=\"dlw-video-frame\">\n                <iframe\n                    src=\"https:\/\/player.vimeo.com\/video\/1236101159?h=5594e71236&amp;badge=0&amp;autopause=0&amp;player_id=0&amp;app_id=58479\"\n                    title=\"Beacon\u00ae Optofluidic Suite2\"\n                    frameborder=\"0\"\n                    allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\"\n                    referrerpolicy=\"strict-origin-when-cross-origin\"\n                    loading=\"lazy\"\n                    allowfullscreen\n                ><\/iframe>\n            <\/div>\n        <\/div>\n    <\/div>\n\n    <div class=\"dlw-step\">\n        <div class=\"dlw-step-heading\">\n            <span class=\"dlw-step-number\">2<\/span>\n            <h3>On-chip culture and functional assays<\/h3>\n        <\/div>\n\n        <p>\n            Cells are incubated under controlled physiological conditions of temperature, gas and perfusion. The platform automatically performs multiple sequential dynamic assays on the same chip:\n        <\/p>\n\n        <div class=\"dlw-list\">\n            <span class=\"dlw-list-item\">Protein or antibody secretion assays (detection of localized fluorescence within minutes).<\/span>\n            <span class=\"dlw-list-item\">Real-time targeted cytotoxicity assays (co-culture of effector T cells or CAR-T cells with target cells).<\/span>\n            <span class=\"dlw-list-item\">Evaluation of cell proliferation kinetics.<\/span>\n        <\/div>\n\n        <div class=\"dlw-video-block\">\n            <div class=\"dlw-video-frame\">\n                <iframe\n                    src=\"https:\/\/player.vimeo.com\/video\/1236101155?h=f078033627&amp;badge=0&amp;autopause=0&amp;player_id=0&amp;app_id=58479\"\n                    title=\"Beacon\u00ae Optofluidic Suite3\"\n                    frameborder=\"0\"\n                    allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\"\n                    referrerpolicy=\"strict-origin-when-cross-origin\"\n                    loading=\"lazy\"\n                    allowfullscreen\n                ><\/iframe>\n            <\/div>\n        <\/div>\n\n        <div class=\"dlw-video-pair\">\n            <div class=\"dlw-video-frame dlw-video-frame--portrait\">\n                <iframe\n                    src=\"https:\/\/player.vimeo.com\/video\/1236101158?h=0d79b6f35a&amp;badge=0&amp;autopause=0&amp;player_id=0&amp;app_id=58479\"\n                    title=\"Beacon\u00ae Optofluidic Suite4\"\n                    frameborder=\"0\"\n                    allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\"\n                    referrerpolicy=\"strict-origin-when-cross-origin\"\n                    loading=\"lazy\"\n                    allowfullscreen\n                ><\/iframe>\n            <\/div>\n\n            <div class=\"dlw-video-frame dlw-video-frame--cinema\">\n                <iframe\n                    src=\"https:\/\/player.vimeo.com\/video\/1236101169?h=7fbbe28523&amp;badge=0&amp;autopause=0&amp;player_id=0&amp;app_id=58479\"\n                    title=\"Beacon\u00ae Optofluidic Suite5\"\n                    frameborder=\"0\"\n                    allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\"\n                    referrerpolicy=\"strict-origin-when-cross-origin\"\n                    loading=\"lazy\"\n                    allowfullscreen\n                ><\/iframe>\n            <\/div>\n        <\/div>\n    <\/div>\n\n    <div class=\"dlw-step\">\n        <div class=\"dlw-step-heading\">\n            <span class=\"dlw-step-number\">3<\/span>\n            <h3>Automated data analysis with Cell Analysis Software (CAS)<\/h3>\n        <\/div>\n\n        <p>\n            The CAS (Cell Analysis Software) software suite processes and integrates optical and kinetic images in real time, generating multidimensional profiles that define the behavior of each individual cell. The system quantitatively associates complex phenotypes, cellular interactions and specific secretion indices.\n        <\/p>\n    <\/div>\n\n    <div class=\"dlw-step\">\n        <div class=\"dlw-step-heading\">\n            <span class=\"dlw-step-number\">4<\/span>\n            <h3>Clonal selection and export<\/h3>\n        <\/div>\n\n        <p>\n            Based on the functional criteria defined by the researcher, the platform again uses optoelectronic force to export only the cells of interest\u2014for example, high-affinity antibody-producing clones or highly cytotoxic active T cells\u2014directly into standard molecular biology formats for subsequent molecular characterization or expansion.\n        <\/p>\n\n        <div class=\"dlw-video-block\">\n            <div class=\"dlw-video-frame\">\n                <iframe\n                    src=\"https:\/\/player.vimeo.com\/video\/1236101180?h=98511826f2&amp;badge=0&amp;autopause=0&amp;player_id=0&amp;app_id=58479\"\n                    title=\"Beacon\u00ae Optofluidic Suite6\"\n                    frameborder=\"0\"\n                    allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\"\n                    referrerpolicy=\"strict-origin-when-cross-origin\"\n                    loading=\"lazy\"\n                    allowfullscreen\n                ><\/iframe>\n            <\/div>\n        <\/div>\n    <\/div>\n\n    <h2>Applications<\/h2>\n\n    <div class=\"dlw-app-grid\">\n\n        <article class=\"dlw-app-card\">\n            <figure class=\"dlw-app-image-wrap\">\n                <img decoding=\"async\"\n                    src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/10\/1-2.webp\"\n                    alt=\"Therapeutic antibody discovery\"\n                    class=\"dlw-app-img\"\n                    data-dlw-lightbox\n                    tabindex=\"0\"\n                    role=\"button\"\n                >\n            <\/figure>\n\n            <div class=\"dlw-app-content\">\n                <h3 class=\"dlw-app-title\">\n                    <a href=\"https:\/\/brukercellularanalysis.com\/applications\/antibody-discovery\/\" target=\"_blank\" rel=\"noopener noreferrer\">Therapeutic antibody discovery<\/a>\n                <\/h3>\n\n                <div class=\"dlw-list\">\n                    <span class=\"dlw-list-item\">Comprehensive screening and direct characterization of primary human or animal B cells (Memory B cells, Plasma cells) and hybridoma cell lines in less than one week.<\/span>\n                    <span class=\"dlw-list-item\">Direct on-chip functional characterization: binding affinity, antigen specificity, cross-reactivity and ligand blocking.<\/span>\n                <\/div>\n            <\/div>\n        <\/article>\n\n        <article class=\"dlw-app-card\">\n            <figure class=\"dlw-app-image-wrap\">\n                <img decoding=\"async\"\n                    src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/10\/2-1.webp\"\n                    alt=\"T-cell profiling and functionality\"\n                    class=\"dlw-app-img\"\n                    data-dlw-lightbox\n                    tabindex=\"0\"\n                    role=\"button\"\n                >\n            <\/figure>\n\n            <div class=\"dlw-app-content\">\n                <h3 class=\"dlw-app-title\">\n                    <a href=\"https:\/\/brukercellularanalysis.com\/applications\/t-cell-profiling\/\" target=\"_blank\" rel=\"noopener noreferrer\">T-cell profiling and functionality<\/a>\n                <\/h3>\n\n                <div class=\"dlw-list\">\n                    <span class=\"dlw-list-item\">Evaluation of immunotherapies through the simultaneous analysis of targeted cytotoxicity, surface marker phenotyping and cytokine secretion rates in T-cell and CAR-T-cell populations.<\/span>\n                    <span class=\"dlw-list-item\">Direct linkage of the functional response with cell-by-cell T-cell receptor sequencing (TCR-seq).<\/span>\n                <\/div>\n            <\/div>\n        <\/article>\n\n        <article class=\"dlw-app-card\">\n            <figure class=\"dlw-app-image-wrap\">\n                <img decoding=\"async\"\n                    src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/10\/3.webp\"\n                    alt=\"Cell Line Development\"\n                    class=\"dlw-app-img\"\n                    data-dlw-lightbox\n                    tabindex=\"0\"\n                    role=\"button\"\n                >\n            <\/figure>\n\n            <div class=\"dlw-app-content\">\n                <h3 class=\"dlw-app-title\">\n                    <a href=\"https:\/\/brukercellularanalysis.com\/applications\/cell-line-development\/\" target=\"_blank\" rel=\"noopener noreferrer\">Cell Line Development<\/a>\n                <\/h3>\n\n                <div class=\"dlw-list\">\n                    <span class=\"dlw-list-item\">Ensures documented monoclonality from day zero through continuous historical image tracking of each NanoPen\u00ae microchamber.<\/span>\n                    <span class=\"dlw-list-item\">Automated selection of the fastest-growing CHO clones with the highest therapeutic protein productivity, minimizing costly plate-passage stages.<\/span>\n                <\/div>\n            <\/div>\n        <\/article>\n\n    <\/div>\n\n    <h2>Equipment specifications<\/h2>\n\n    <p class=\"dlw-table-intro\">\n        To meet the needs of each laboratory, Bruker\u2019s optofluidic suite is available in two highly scalable configurations:\n    <\/p>\n\n    <div class=\"dlw-table-wrap\">\n        <table class=\"dlw-spec-table\">\n            <thead>\n                <tr>\n                    <th scope=\"col\">Feature\/configuration<\/th>\n                    <th scope=\"col\">Beacon\u00ae Optofluidic System<\/th>\n                    <th scope=\"col\">Beacon Discovery&#x2122;<\/th>\n                <\/tr>\n            <\/thead>\n            <tbody>\n                <tr>\n                    <td data-label=\"Feature\/configuration\">Primary focus<\/td>\n                    <td data-label=\"Beacon\u00ae Optofluidic System\">Large-scale biotechnology and pharmaceutical industry, CDMOs and high-throughput screening centers.<\/td>\n                    <td data-label=\"Beacon Discovery&#x2122;\">Advanced translational research, immunology and academic antibody discovery.<\/td>\n                <\/tr>\n\n                <tr>\n                    <td data-label=\"Feature\/configuration\">Chip capacity<\/td>\n                    <td data-label=\"Beacon\u00ae Optofluidic System\">Parallel processing of up to 4 chips per run.<\/td>\n                    <td data-label=\"Beacon Discovery&#x2122;\">Optimized processing of 1 chip per run.<\/td>\n                <\/tr>\n\n                <tr>\n                    <td data-label=\"Feature\/configuration\">Cell capacity<\/td>\n                    <td data-label=\"Beacon\u00ae Optofluidic System\">Up to 160,000 individual NanoPens analyzable per run.<\/td>\n                    <td data-label=\"Beacon Discovery&#x2122;\">Up to 20,000 individual NanoPens analyzable per run.<\/td>\n                <\/tr>\n\n                <tr>\n                    <td data-label=\"Feature\/configuration\">Automation and workflow<\/td>\n                    <td data-label=\"Beacon\u00ae Optofluidic System\">Maximum robotic capacity, optimal for continuous 24\/7 processes.<\/td>\n                    <td data-label=\"Beacon Discovery&#x2122;\">Compact, benchtop system designed for experimental flexibility.<\/td>\n                <\/tr>\n            <\/tbody>\n        <\/table>\n    <\/div>\n\n    <div class=\"dlw-cta-wrap\">\n        <a href=\"https:\/\/brukercellularanalysis.com\/\" class=\"dlw-cta\" target=\"_blank\" rel=\"noopener noreferrer\">Learn more<\/a>\n    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By synergistically integrating advanced microfluidics, precision optics, optoelectronics and artificial intelligence, this platform enables the isolation, culture, characterization and recovery of thousands of individual cells in a fully automated manner and in real time. Unlike traditional static or destructive methodologies, Bruker\u2019s [&hellip;]<\/p>\n","protected":false},"featured_media":28595,"template":"","tecnologias":[542],"marcas":[238],"familias":[285,361],"class_list":["post-28598","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-functional-assay","marcas-bruker-en","familias-omics","familias-single-cell-en"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28598\/revisions"}],"predecessor-version":[{"id":28599,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28598\/revisions\/28599"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/28595"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=28598"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=28598"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=28598"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=28598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}