{"id":28664,"date":"2026-10-19T11:11:56","date_gmt":"2026-10-19T11:11:56","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=28664"},"modified":"2026-10-19T11:34:25","modified_gmt":"2026-10-19T11:34:25","slug":"tapestri","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/tapestri\/","title":{"rendered":"Tapestri&#x2122;"},"content":{"rendered":"\n<!-- Complete HTML ready for WordPress \/ Bricks -->\n\n<style>\n@import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:wght@600;700&family=Raleway:wght@400;500;600;700&display=swap');\n\n#dlw-tapestri-en {\n    --dlw-blue-dark: #003a70;\n    --dlw-blue-cyan: #00a1e0;\n    --dlw-light-bg: #f9fbfd;\n    --dlw-grey-bg: #f4f6f8;\n    --dlw-border: #e1e8f0;\n    width: 100% !important;\n    max-width: 720px !important;\n    margin: 0 auto !important;\n    padding: 0 !important;\n    box-sizing: border-box !important;\n    overflow: hidden !important;\n    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overflow: hidden !important;\n    }\n\n    #dlw-tapestri-en p,\n    #dlw-tapestri-en .dlw-lead {\n        text-align: left !important;\n    }\n\n    #dlw-tapestri-en .dlw-lead {\n        padding: 20px !important;\n        font-size: 16px !important;\n    }\n\n    #dlw-tapestri-en .dlw-section-title {\n        font-size: 25px !important;\n    }\n\n    #dlw-tapestri-en .dlw-prod-img {\n        max-width: 100% !important;\n    }\n\n    #dlw-tapestri-en .dlw-key-panel {\n        padding: 22px 18px !important;\n    }\n\n    #dlw-tapestri-en .dlw-key-grid,\n    #dlw-tapestri-en .dlw-panels-grid {\n        grid-template-columns: 1fr !important;\n    }\n\n    #dlw-tapestri-en .dlw-process-item {\n        grid-template-columns: 1fr !important;\n        gap: 13px !important;\n        padding: 17px 15px !important;\n    }\n\n    #dlw-tapestri-en .dlw-process-number {\n        width: auto !important;\n        min-width: 68px !important;\n        max-width: 82px !important;\n    }\n\n    #dlw-tapestri-en .dlw-inline-link {\n        width: 100% !important;\n    }\n\n    #dlw-tapestri-en .dlw-panel-card .dlw-inline-link-wrap {\n        text-align: center !important;\n    }\n\n    #dlw-tapestri-modal-en {\n        padding: 16px !important;\n    }\n\n    #dlw-tapestri-modal-en .dlw-modal-image {\n        max-width: 94vw !important;\n        max-height: 84vh !important;\n    }\n\n    #dlw-tapestri-modal-en .dlw-modal-close {\n        top: -17px !important;\n        right: -8px !important;\n        width: 38px !important;\n        height: 38px !important;\n        font-size: 24px !important;\n    }\n}\n<\/style>\n\n<div id=\"dlw-tapestri-en\" class=\"dlw-prod-wrapper\">\n\n    <section>\n        <h2 class=\"dlw-section-title\">Short description<\/h2>\n\n        <p class=\"dlw-lead\">\n            The Tapestri\u00ae platform enables the simultaneous integration of three biological dimensions from the same individual cell: DNA, RNA and surface proteins. This unprecedented multi-omics capability provides a direct and functional view of how specific genetic alterations (genotype) shape transcriptional expression and protein behaviour (phenotype), without the need to reconcile data from separate platforms.\n        <\/p>\n\n        <p>\n            Conventional high-throughput sequencing technologies (Bulk NGS) provide an averaged view of cell populations. However, in complex diseases such as cancer, clonal evolution does not occur on average. Rare subclonal variations that drive therapeutic resistance, persistence and relapse are often masked by background noise.\n        <\/p>\n    <\/section>\n\n    <div class=\"dlw-figure\">\n        <img decoding=\"async\"\n            src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/10\/Imagen1.webp\"\n            alt=\"Mission Bio Tapestri platform\"\n            class=\"dlw-prod-img\"\n            loading=\"lazy\"\n            tabindex=\"0\"\n            role=\"button\"\n            aria-label=\"Enlarge image\"\n            onclick=\"dlwTapestriOpenModalEn(this)\"\n            onkeydown=\"if(event.key==='Enter'||event.key===' '){event.preventDefault();dlwTapestriOpenModalEn(this);}\"\n        >\n    <\/div>\n\n    <p>\n        The Mission Bio Tapestri\u00ae platform is the first and only solution on the market capable of performing large-scale targeted multi-omics at the single-cell level. By combining precision microfluidic instrumentation, advanced reagents and state-of-the-art bioinformatics tools, Tapestri\u00ae transforms complex samples of individual cells into high-resolution sequencing data, revealing cellular heterogeneity, clonal architecture and direct genotype-phenotype relationships without the need for bioinformatics inference.\n    <\/p>\n\n    <section class=\"dlw-section\">\n        <h2 class=\"dlw-section-title\">Key Features<\/h2>\n\n        <div class=\"dlw-key-panel\">\n            <div class=\"dlw-key-grid\">\n\n                <div class=\"dlw-key-item\">\n                    <strong>True single-cell multi-omics analysis:<\/strong> Unique capability to simultaneously study DNA (mutations, CNVs, SNVs), RNA (selected transcripts) and surface proteins at the individual-cell level in a single assay, avoiding the loss of resolution that occurs in averaged analyses (Bulk).\n                <\/div>\n\n                <div class=\"dlw-key-item\">\n                    <strong>Direct integration with NGS:<\/strong> The complete workflow integrates naturally with the leading next-generation sequencers on the market, providing a comprehensive turnkey solution comprising instrumentation, reagents, panels and bioinformatics.\n                <\/div>\n\n                <div class=\"dlw-key-item\">\n                    <strong>Maximum panel flexibility:<\/strong> Full compatibility with predesigned catalogue panels (Oncology, Haematology, Immunotherapy, etc.), panels published by research consortia, virtual panels and the design of 100% customised DNA and antibody panels through Tapestri Designer.\n                <\/div>\n\n                <div class=\"dlw-key-item\">\n                    <strong>High-impact clinical and scientific applications:<\/strong> An essential tool for studying tumour heterogeneity, the ultra-sensitive characterisation of measurable residual disease (scMRD), the reconstruction of clonal architecture, and the validation of zygosity and off-target effects in CRISPR gene editing.\n                <\/div>\n\n                <div class=\"dlw-key-item\">\n                    <strong>Optimised bioinformatics ecosystem:<\/strong> Access to the advanced Tapestri Pipeline and Tapestri Insights tools, specifically designed to process, normalise, correlate and visualise complex multi-analyte data in a visual and intuitive way, without requiring dedicated programmers.\n                <\/div>\n\n            <\/div>\n        <\/div>\n    <\/section>\n\n    <section class=\"dlw-section\">\n        <h2 class=\"dlw-section-title\">How does it work?<\/h2>\n\n        <p>\n            TapestriTM integrates into a next-generation sequencing (NGS) workflow, providing a complete solution from individual cells to sequencing data and its analysis. It covers everything from panel design or the selection of predesigned panels to bioinformatics analysis on the Tapestri Pipeline and Tapestri Insights platforms.\n        <\/p>\n\n        <p>\n            The solution incorporates Tapestri Pipeline and Tapestri Insights, bioinformatics tools optimised for the analysis of DNA and proteins at the single-cell level.\n        <\/p>\n\n        <div class=\"dlw-list\">\n            <span class=\"dlw-list-item\">They allow sequences to be imported and the data to be analysed and visualised.<\/span>\n            <span class=\"dlw-list-item\">They include report-generation solutions for multiple myeloma, AML and genome editing.<\/span>\n            <span class=\"dlw-list-item\">They provide interactive charts and visualisations to facilitate the interpretation of multi-analyte data.<\/span>\n        <\/div>\n\n        <div class=\"dlw-figure\">\n            <img decoding=\"async\"\n                src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/10\/Imagen2en.webp\"\n                alt=\"Tapestri platform workflow\"\n                class=\"dlw-prod-img\"\n                loading=\"lazy\"\n                tabindex=\"0\"\n                role=\"button\"\n                aria-label=\"Enlarge image\"\n                onclick=\"dlwTapestriOpenModalEn(this)\"\n                onkeydown=\"if(event.key==='Enter'||event.key===' '){event.preventDefault();dlwTapestriOpenModalEn(this);}\"\n            >\n        <\/div>\n\n        <p>\n            Unlike traditional one-step microfluidic systems, which limit the types of reagents that can interact with the cell, Tapestri\u00ae uses an exclusive two-step workflow that independently optimises each chemical reaction:\n        <\/p>\n\n        <div class=\"dlw-process\">\n\n            <div class=\"dlw-process-item\">\n                <div class=\"dlw-process-number\">Step 0<\/div>\n                <div class=\"dlw-process-text\">\n                    <strong>Antibody incubation (AOCs):<\/strong> Individual cells are incubated with oligonucleotide-conjugated antibodies (antibody tags) to capture membrane proteins.\n                <\/div>\n            <\/div>\n\n            <div class=\"dlw-process-item\">\n                <div class=\"dlw-process-number\">Step 1<\/div>\n                <div class=\"dlw-process-text\">\n                    <strong>Cell lysis and access to DNA.<\/strong> Individual antibody-bound cells are encapsulated in microdroplets together with a thermal lysis buffer and protease. This digests the protein matrix of the chromatin and makes the genomic DNA fully accessible for amplification, while the cellular RNA remains available for conversion into complementary DNA (cDNA) through reverse transcription.\n                <\/div>\n            <\/div>\n\n            <div class=\"dlw-process-item\">\n                <div class=\"dlw-process-number\">Step 2<\/div>\n                <div class=\"dlw-process-text\">\n                    <strong>Barcoding and multiplex PCR.<\/strong> Beads with unique molecular barcodes and specific primers are added to perform targeted multiplex PCR amplification. Each DNA amplicon, RNA transcript and antibody tag therefore receives the same specific barcode, enabling the cellular origin of all analysed molecules to be unequivocally identified.\n                <\/div>\n            <\/div>\n\n        <\/div>\n\n        <div class=\"dlw-figure\">\n            <img decoding=\"async\"\n                src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/10\/Imagen3en-1.webp\"\n                alt=\"Barcoding and multiplex PCR on the Tapestri platform\"\n                class=\"dlw-prod-img\"\n                loading=\"lazy\"\n                tabindex=\"0\"\n                role=\"button\"\n                aria-label=\"Enlarge image\"\n                onclick=\"dlwTapestriOpenModalEn(this)\"\n                onkeydown=\"if(event.key==='Enter'||event.key===' '){event.preventDefault();dlwTapestriOpenModalEn(this);}\"\n            >\n        <\/div>\n    <\/section>\n\n    <section class=\"dlw-section\">\n        <h2 class=\"dlw-section-title\">Available panels<\/h2>\n\n        <p>\n            The Tapestri\u00ae platform offers unprecedented versatility through its targeted panel architecture. Panels can be selected, combined and customised according to the needs and biological scope of the project, and are divided into three key analytes: DNA, surface proteins and RNA.\n        <\/p>\n\n        <div class=\"dlw-inline-link-wrap\">\n            <a href=\"https:\/\/www.missionbio.com\/products\/panels\" class=\"dlw-inline-link\" target=\"_blank\" rel=\"noopener noreferrer\">\n                Available panels\n            <\/a>\n        <\/div>\n\n        <div class=\"dlw-panels-grid\">\n\n            <article class=\"dlw-panel-card\">\n                <h3>A. Single-Cell DNA Panels (SNVs and CNVs)<\/h3>\n                <p>\n                    DNA panels are designed to interrogate single-nucleotide variants (SNVs) and copy-number variations (CNVs) with exceptional coverage and uniformity, typically using between 20 and 500 amplicons.\n                <\/p>\n            <\/article>\n\n            <article class=\"dlw-panel-card\">\n                <h3>B. Surface Protein Panels (Immunophenotyping)<\/h3>\n                <p>\n                    They enable the simultaneous quantification of cell membrane proteins using oligonucleotide-conjugated antibodies, providing unprecedented phenotypic resolution at the single-cell level.\n                <\/p>\n            <\/article>\n\n            <article class=\"dlw-panel-card\">\n                <h3>C. Targeted RNA Panels (Single-Cell Targeted RNA)<\/h3>\n                <p>\n                    This new analyte on the Tapestri\u00ae platform makes it possible to evaluate the functional gene-expression signature to complement single-cell DNA genotyping information.\n                <\/p>\n            <\/article>\n\n            <article class=\"dlw-panel-card\">\n                <h3>D. Custom panels<\/h3>\n\n                <p>\n                    Unlimited flexibility for precision medicine. Combine mutation markers (DNA) and surface proteins specifically designed for your clinical cohort, accelerating the discovery of rare clones and resistance mechanisms.\n                <\/p>\n\n                <div class=\"dlw-inline-link-wrap\">\n                    <a href=\"https:\/\/designer.missionbio.com\/\" class=\"dlw-inline-link\" target=\"_blank\" rel=\"noopener noreferrer\">\n                        Custom panels\n                    <\/a>\n                <\/div>\n            <\/article>\n\n        <\/div>\n    <\/section>\n\n    <div class=\"dlw-cta-wrap\">\n        <a href=\"https:\/\/www.missionbio.com\/capabilities\/dna-protein\" class=\"dlw-cta\" target=\"_blank\" rel=\"noopener noreferrer\">\n            Learn more\n        <\/a>\n    <\/div>\n\n<\/div>\n\n<!-- Image lightbox -->\n<div\n    id=\"dlw-tapestri-modal-en\"\n    role=\"dialog\"\n    aria-modal=\"true\"\n    aria-label=\"Enlarged image\"\n    aria-hidden=\"true\"\n    onclick=\"if(event.target===this){dlwTapestriCloseModalEn();}\"\n>\n    <div\n        class=\"dlw-modal-dialog\"\n        onclick=\"if(event.target===this){dlwTapestriCloseModalEn();}\"\n    >\n        <button\n            type=\"button\"\n            class=\"dlw-modal-close\"\n            aria-label=\"Close image\"\n            onclick=\"event.stopPropagation();dlwTapestriCloseModalEn();\"\n        >\n            &times;\n        <\/button>\n\n        <img decoding=\"async\"\n            src=\"\"\n            alt=\"Enlarged image\"\n            class=\"dlw-modal-image\"\n            onclick=\"event.stopPropagation();dlwTapestriCloseModalEn();\"\n        >\n    <\/div>\n<\/div>\n\n<script>\n(function () {\n    var previousBodyOverflow = \"\";\n\n    window.dlwTapestriOpenModalEn = function (imageElement) {\n        var modal = document.getElementById(\"dlw-tapestri-modal-en\");\n\n        if (!modal || !imageElement || !imageElement.src) {\n            return;\n        }\n\n        var modalImage = modal.querySelector(\".dlw-modal-image\");\n        var closeButton = modal.querySelector(\".dlw-modal-close\");\n\n        if (!modalImage) {\n            return;\n        }\n\n        previousBodyOverflow = document.body.style.overflow || \"\";\n\n        modalImage.src = imageElement.currentSrc || imageElement.src;\n        modalImage.alt = imageElement.alt || \"Enlarged image\";\n\n        modal.classList.add(\"dlw-modal-open\");\n        modal.setAttribute(\"aria-hidden\", \"false\");\n        document.body.style.overflow = \"hidden\";\n\n        if (closeButton) {\n            window.setTimeout(function () {\n                closeButton.focus();\n            }, 0);\n        }\n    };\n\n    window.dlwTapestriCloseModalEn = function () {\n        var modal = document.getElementById(\"dlw-tapestri-modal-en\");\n\n        if (!modal) {\n            return;\n        }\n\n        var modalImage = modal.querySelector(\".dlw-modal-image\");\n\n        modal.classList.remove(\"dlw-modal-open\");\n        modal.setAttribute(\"aria-hidden\", \"true\");\n        document.body.style.overflow = previousBodyOverflow;\n\n        if (modalImage) {\n            modalImage.src = \"\";\n        }\n    };\n\n    function handleEscape(event) {\n        if (event.key !== \"Escape\") {\n            return;\n        }\n\n        var modal = document.getElementById(\"dlw-tapestri-modal-en\");\n\n        if (modal && modal.classList.contains(\"dlw-modal-open\")) {\n            window.dlwTapestriCloseModalEn();\n        }\n    }\n\n    if (!window.dlwTapestriEscapeReadyEn) {\n        document.addEventListener(\"keydown\", handleEscape);\n        window.dlwTapestriEscapeReadyEn = true;\n    }\n})();\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>Short description The Tapestri\u00ae platform enables the simultaneous integration of three biological dimensions from the same individual cell: DNA, RNA and surface proteins. This unprecedented multi-omics capability provides a direct and functional view of how specific genetic alterations (genotype) shape transcriptional expression and protein behaviour (phenotype), without the need to reconcile data from separate platforms. 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