{"id":28697,"date":"2026-10-20T13:02:57","date_gmt":"2026-10-20T13:02:57","guid":{"rendered":"https:\/\/www.dlongwood.com\/?post_type=productos&#038;p=28697"},"modified":"2026-10-20T13:08:20","modified_gmt":"2026-10-20T13:08:20","slug":"fusionplex-heme-v3-pan-heme-v2","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/fusionplex-heme-v3-pan-heme-v2\/","title":{"rendered":"FUSIONPlex&#x2122; Heme v3 &amp; Pan-Heme v2"},"content":{"rendered":"\n<!-- Complete HTML ready for WordPress \/ Bricks -->\n\n<style>\n@import url('https:\/\/fonts.googleapis.com\/css2?family=Playfair+Display:wght@600;700&family=Raleway:wght@400;500;600;700&display=swap');\n\n#dlw-fusionplex-heme-en {\n    --dlw-blue-dark: #003a70;\n    --dlw-blue-cyan: #00a1e0;\n    --dlw-light-bg: #f9fbfd;\n    --dlw-grey-bg: #f4f6f8;\n    --dlw-border: #e1e8f0;\n    width: 100% !important;\n    max-width: 720px !important;\n    margin: 0 auto !important;\n    padding: 0 !important;\n   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  color: #ffffff !important;\n    font-family: Arial, sans-serif !important;\n    font-size: 27px !important;\n    font-weight: 400 !important;\n    line-height: 1 !important;\n    cursor: pointer !important;\n}\n\n@media (max-width: 768px) {\n    #dlw-fusionplex-heme-en {\n        width: 100% !important;\n        max-width: 100% !important;\n        overflow: hidden !important;\n    }\n\n    #dlw-fusionplex-heme-en p,\n    #dlw-fusionplex-heme-en .dlw-lead {\n        text-align: left !important;\n    }\n\n    #dlw-fusionplex-heme-en .dlw-lead {\n        padding: 20px !important;\n        font-size: 16px !important;\n    }\n\n    #dlw-fusionplex-heme-en .dlw-section-title {\n        font-size: 25px !important;\n    }\n\n    #dlw-fusionplex-heme-en .dlw-subtitle {\n        font-size: 21px !important;\n    }\n\n    #dlw-fusionplex-heme-en .dlw-prod-img {\n        max-width: 100% !important;\n    }\n\n    #dlw-fusionplex-heme-en .dlw-card-list,\n    #dlw-fusionplex-heme-en .dlw-key-grid,\n    #dlw-fusionplex-heme-en .dlw-presentation-grid {\n        grid-template-columns: 1fr !important;\n    }\n\n    #dlw-fusionplex-heme-en .dlw-key-panel {\n        padding: 22px 18px !important;\n    }\n\n    #dlw-fusionplex-heme-en .dlw-details-summary {\n        padding: 16px 54px 16px 18px !important;\n        font-size: 20px !important;\n    }\n\n    #dlw-fusionplex-heme-en .dlw-details-content {\n        padding: 16px !important;\n    }\n\n    #dlw-fusionplex-modal-en {\n        padding: 16px !important;\n    }\n\n    #dlw-fusionplex-modal-en .dlw-modal-image {\n        max-width: 94vw !important;\n        max-height: 84vh !important;\n    }\n\n    #dlw-fusionplex-modal-en .dlw-modal-close {\n        top: -17px !important;\n        right: -8px !important;\n        width: 38px !important;\n        height: 38px !important;\n        font-size: 24px !important;\n    }\n}\n<\/style>\n\n<div id=\"dlw-fusionplex-heme-en\" class=\"dlw-prod-wrapper\">\n\n    <p class=\"dlw-lead\">\n        RNA-based next-generation sequencing solution for the analytically sensitive identification of known and novel gene fusions, splicing variants, exon-skipping events, SNVs\/Indels and gene expression in haematological malignancy research.\n    <\/p>\n\n    <p>\n        FUSIONPlex Pan-Heme v2 provides broad coverage of 218 genes associated with haematological malignancies, while FUSIONPlex Heme v3 provides more focused coverage of 121 genes targeting alterations frequently found in leukaemia while retaining markers relevant to other haematological diseases.\n    <\/p>\n\n    <div class=\"dlw-figure\">\n        <img decoding=\"async\"\n            src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/10\/1-4.webp\"\n            alt=\"FUSIONPlex Heme v3 and Pan-Heme v2\"\n            class=\"dlw-prod-img\"\n            loading=\"lazy\"\n            tabindex=\"0\"\n            role=\"button\"\n            aria-label=\"Enlarge image\"\n            onclick=\"dlwFusionPlexOpenModalEn(this)\"\n            onkeydown=\"if(event.key==='Enter'||event.key===' '){event.preventDefault();dlwFusionPlexOpenModalEn(this);}\"\n        >\n    <\/div>\n\n    <section class=\"dlw-section\">\n        <h2 class=\"dlw-section-title\">Detailed Description<\/h2>\n\n        <h3 class=\"dlw-subtitle\">Operating Principle<\/h3>\n\n        <p>\n            The Archer FUSIONPlex Heme v3 &amp; Pan-Heme v2 solutions are based on Anchored Multiplex PCR (AMP&#x2122;) chemistry, a proprietary multiplex PCR strategy that uses unidirectional gene-specific primers to enrich target regions and enable the detection of known and unknown alterations. The adapters incorporate molecular barcodes (MBCs, Molecular Barcodes) and sample indices, enabling multiplexed analysis, read deduplication, error correction and high-confidence variant calling.\n        <\/p>\n\n        <p>\n            The approach is designed for RNA fusion analysis, enabling expressed fusion transcripts to be captured and avoiding the technical and economic difficulties associated with sequencing large repetitive intronic regions in DNA-based assays. In combination with de novo assembly and Archer Analysis software, FUSIONPlex enables the sensitive identification of known and novel fusions, including fusions with previously unidentified partners (fusion-agnostic).\n        <\/p>\n\n        <div class=\"dlw-figure\">\n            <img decoding=\"async\"\n                src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/10\/2en-1.webp\"\n                alt=\"FUSIONPlex operating principle using AMP\"\n                class=\"dlw-prod-img\"\n                loading=\"lazy\"\n                tabindex=\"0\"\n                role=\"button\"\n                aria-label=\"Enlarge image\"\n                onclick=\"dlwFusionPlexOpenModalEn(this)\"\n                onkeydown=\"if(event.key==='Enter'||event.key===' '){event.preventDefault();dlwFusionPlexOpenModalEn(this);}\"\n            >\n        <\/div>\n    <\/section>\n\n    <section class=\"dlw-section\">\n        <h2 class=\"dlw-section-title\">Benefits<\/h2>\n\n        <div class=\"dlw-card-list\">\n\n            <div class=\"dlw-card-item\">\n                Enables multiple types of alterations to be characterised in a single workflow, reducing the need for separate assays.\n            <\/div>\n\n            <div class=\"dlw-card-item\">\n                Identifies known and novel fusions, including complex fusions or those with variable partners.\n            <\/div>\n\n            <div class=\"dlw-card-item\">\n                Supports panel content customisation to incorporate new biomarkers or adapt to specific areas of research.\n            <\/div>\n\n            <div class=\"dlw-card-item\">\n                Compatible with manual or automated library preparation; consult the available automation options.\n            <\/div>\n\n            <div class=\"dlw-card-item\">\n                Fast and simple manual workflow: 1.5-day library preparation with 3.5 hours of hands-on time. Uses colour coding and lyophilised reagents for a simple and intuitive workflow.\n            <\/div>\n\n            <div class=\"dlw-card-item\">\n                Integration with Archer Analysis, a secondary analysis platform designed to simplify interpretation and generate high-level and detailed mutation reports.\n            <\/div>\n\n        <\/div>\n    <\/section>\n\n    <section class=\"dlw-section\">\n        <h2 class=\"dlw-section-title\">Technology Used<\/h2>\n\n        <div class=\"dlw-list\">\n            <span class=\"dlw-list-item\">RNA-based next-generation sequencing (NGS).<\/span>\n            <span class=\"dlw-list-item\">Anchored Multiplex PCR (AMP&#x2122;) chemistry.<\/span>\n            <span class=\"dlw-list-item\">Gene-specific primers (GSPs) for targeted enrichment.<\/span>\n            <span class=\"dlw-list-item\">MBC adapters for molecular tagging, read deduplication and error correction.<\/span>\n            <span class=\"dlw-list-item\">Archer Analysis for bioinformatics analysis, visualisation and interpretation support.<\/span>\n            <span class=\"dlw-list-item\">FUSIONPlex panels compatible with libraries generated from RNA or total nucleic acid (TNA), depending on the protocol and application.<\/span>\n        <\/div>\n\n        <div class=\"dlw-figure\">\n            <img decoding=\"async\"\n                src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2026\/10\/3en-1.webp\"\n                alt=\"Technology used by FUSIONPlex Heme v3 and Pan-Heme v2\"\n                class=\"dlw-prod-img\"\n                loading=\"lazy\"\n                tabindex=\"0\"\n                role=\"button\"\n                aria-label=\"Enlarge image\"\n                onclick=\"dlwFusionPlexOpenModalEn(this)\"\n                onkeydown=\"if(event.key==='Enter'||event.key===' '){event.preventDefault();dlwFusionPlexOpenModalEn(this);}\"\n            >\n        <\/div>\n    <\/section>\n\n    <section class=\"dlw-section\">\n        <h2 class=\"dlw-section-title\">Intended Audience\/User<\/h2>\n\n        <div class=\"dlw-audience\">\n            <p>\n                Molecular diagnostics, haematology, haemato-oncology and haematological malignancy genomics laboratories requiring the characterisation of fusions, splicing alterations, SNVs\/Indels and gene expression using NGS.\n            <\/p>\n\n            <p>\n                The protocols are intended for research applications (RUO) and must be used together with Archer reagent kits and the corresponding sequencing kits for Illumina or Ion Torrent platforms.\n            <\/p>\n        <\/div>\n    <\/section>\n\n    <section class=\"dlw-section\">\n        <h2 class=\"dlw-section-title\">Key Features<\/h2>\n\n        <div class=\"dlw-key-panel\">\n            <div class=\"dlw-key-grid\">\n\n                <div class=\"dlw-key-item\">\n                    RNA-based NGS solution for research into haematological malignancies.\n                <\/div>\n\n                <div class=\"dlw-key-item\">\n                    Detection of known and novel fusions, splicing variants, exon-skipping, SNVs\/Indels and relative expression.\n                <\/div>\n\n                <div class=\"dlw-key-item\">\n                    AMP&#x2122; chemistry with gene-specific primers and molecular barcodes.\n                <\/div>\n\n                <div class=\"dlw-key-item\">\n                    Broad coverage with Pan-Heme v2: 218 genes.\n                <\/div>\n\n                <div class=\"dlw-key-item\">\n                    Focused Heme v3 option: 121 genes.\n                <\/div>\n\n                <div class=\"dlw-key-item\">\n                    Library preparation in 1.5 days with 3.5 hours of hands-on time.\n                <\/div>\n\n                <div class=\"dlw-key-item\">\n                    Compatible with Archer Analysis for secondary analysis and visualisation.\n                <\/div>\n\n                <div class=\"dlw-key-item\">\n                    Ability to customise content and combine it with other Archer panels.\n                <\/div>\n\n                <div class=\"dlw-key-item\">\n                    Available in standard FUSIONPlex format and FUSIONPlex-HT format for high-volume laboratories.\n                <\/div>\n\n                <div class=\"dlw-key-item\">\n                    For research use only; not suitable for diagnostic procedures.\n                <\/div>\n\n            <\/div>\n        <\/div>\n    <\/section>\n\n    <section class=\"dlw-section\">\n        <details class=\"dlw-details\">\n            <summary class=\"dlw-details-summary\">Presentation Details<\/summary>\n\n            <div class=\"dlw-details-content\">\n\n                <div class=\"dlw-presentation-grid\">\n\n                    <article class=\"dlw-presentation-card\">\n                        <h3 class=\"dlw-presentation-title\">FUSIONPlex\/ FUSIONPlex-HT Pan-Heme v2 Panel<\/h3>\n\n                        <div class=\"dlw-presentation-list\">\n                            <span class=\"dlw-presentation-item\"><strong>Coverage:<\/strong> 218 genes.<\/span>\n                            <span class=\"dlw-presentation-item\"><strong>Contents:<\/strong> 1748 gene-specific primers (GSPs).<\/span>\n                            <span class=\"dlw-presentation-item\"><strong>Recommended reads:<\/strong> 10 million paired-end<\/span>\n                            <span class=\"dlw-presentation-item\"><strong>Product number:<\/strong> 10031718<\/span>\n                        <\/div>\n                    <\/article>\n\n                    <article class=\"dlw-presentation-card\">\n                        <h3 class=\"dlw-presentation-title\">FUSIONPlex\/ FUSIONPlex-HT Heme v3 Panel<\/h3>\n\n                        <div class=\"dlw-presentation-list\">\n                            <span class=\"dlw-presentation-item\"><strong>Coverage:<\/strong> 121 genes.<\/span>\n                            <span class=\"dlw-presentation-item\"><strong>Contents:<\/strong> 1205 GSPs<\/span>\n                            <span class=\"dlw-presentation-item\"><strong>Recommended reads:<\/strong> 7 million paired-end<\/span>\n                        <\/div>\n                    <\/article>\n\n                <\/div>\n\n                <div class=\"dlw-presentation-note\">\n                    <p>\n                        FUSIONPlex Heme v3 and PanHeme v2 can be used as standalone panels, combined with other Archer research panels or customised for specific requirements. It can also be combined with VARIANTPlex&#x2122; Myeloid v2 for comprehensive genomic characterisation and with IMMUNOVerse&#x2122; BCR for immune profiling.\n                    <\/p>\n                <\/div>\n\n            <\/div>\n        <\/details>\n    <\/section>\n\n<\/div>\n\n<!-- Image lightbox -->\n<div\n    id=\"dlw-fusionplex-modal-en\"\n    role=\"dialog\"\n    aria-modal=\"true\"\n    aria-label=\"Enlarged image\"\n    aria-hidden=\"true\"\n    onclick=\"if(event.target===this){dlwFusionPlexCloseModalEn();}\"\n>\n    <div\n        class=\"dlw-modal-dialog\"\n        onclick=\"if(event.target===this){dlwFusionPlexCloseModalEn();}\"\n    >\n        <button\n            type=\"button\"\n            class=\"dlw-modal-close\"\n            aria-label=\"Close image\"\n            onclick=\"event.stopPropagation();dlwFusionPlexCloseModalEn();\"\n        >\n            &times;\n        <\/button>\n\n        <img decoding=\"async\"\n            src=\"\"\n            alt=\"Enlarged image\"\n            class=\"dlw-modal-image\"\n            onclick=\"event.stopPropagation();dlwFusionPlexCloseModalEn();\"\n        >\n    <\/div>\n<\/div>\n\n<script>\n(function () {\n    var previousBodyOverflow = \"\";\n\n    window.dlwFusionPlexOpenModalEn = function (imageElement) {\n        var modal = document.getElementById(\"dlw-fusionplex-modal-en\");\n\n        if (!modal || !imageElement || !imageElement.src) {\n            return;\n        }\n\n        var modalImage = modal.querySelector(\".dlw-modal-image\");\n        var closeButton = modal.querySelector(\".dlw-modal-close\");\n\n        if (!modalImage) {\n            return;\n        }\n\n        previousBodyOverflow = document.body.style.overflow || \"\";\n\n        modalImage.src = imageElement.currentSrc || imageElement.src;\n        modalImage.alt = imageElement.alt || \"Enlarged image\";\n\n        modal.classList.add(\"dlw-modal-open\");\n        modal.setAttribute(\"aria-hidden\", \"false\");\n        document.body.style.overflow = \"hidden\";\n\n        if (closeButton) {\n            window.setTimeout(function () {\n                closeButton.focus();\n            }, 0);\n        }\n    };\n\n    window.dlwFusionPlexCloseModalEn = function () {\n        var modal = document.getElementById(\"dlw-fusionplex-modal-en\");\n\n        if (!modal) {\n            return;\n        }\n\n        var modalImage = modal.querySelector(\".dlw-modal-image\");\n\n        modal.classList.remove(\"dlw-modal-open\");\n        modal.setAttribute(\"aria-hidden\", \"true\");\n        document.body.style.overflow = previousBodyOverflow;\n\n        if (modalImage) {\n            modalImage.src = \"\";\n        }\n    };\n\n    function handleEscape(event) {\n        if (event.key !== \"Escape\") {\n            return;\n        }\n\n        var modal = document.getElementById(\"dlw-fusionplex-modal-en\");\n\n        if (modal && modal.classList.contains(\"dlw-modal-open\")) {\n            window.dlwFusionPlexCloseModalEn();\n        }\n    }\n\n    if (!window.dlwFusionPlexEscapeReadyEn) {\n        document.addEventListener(\"keydown\", handleEscape);\n        window.dlwFusionPlexEscapeReadyEn = true;\n    }\n})();\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>RNA-based next-generation sequencing solution for the analytically sensitive identification of known and novel gene fusions, splicing variants, exon-skipping events, SNVs\/Indels and gene expression in haematological malignancy research. FUSIONPlex Pan-Heme v2 provides broad coverage of 218 genes associated with haematological malignancies, while FUSIONPlex Heme v3 provides more focused coverage of 121 genes targeting alterations frequently found [&hellip;]<\/p>\n","protected":false},"featured_media":28687,"template":"","tecnologias":[36],"marcas":[217],"familias":[336,339,340],"class_list":["post-28697","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-next-generation-sequencing-ngs","marcas-archer-dx-en","familias-oncohematology","familias-lymphoid-line","familias-myeloid-line"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28697","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":1,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28697\/revisions"}],"predecessor-version":[{"id":28698,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/28697\/revisions\/28698"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/28687"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=28697"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=28697"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=28697"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=28697"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}