{"id":7900,"date":"2019-11-07T15:58:32","date_gmt":"2019-11-07T15:58:32","guid":{"rendered":"https:\/\/www.dlongwood.com\/cysticfibrosis-cf-eu2\/"},"modified":"2025-01-21T14:52:12","modified_gmt":"2025-01-21T14:52:12","slug":"cysticfibrosis-cf-eu2","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/cysticfibrosis-cf-eu2\/","title":{"rendered":"Cystic Fibrosis – CF-EU2"},"content":{"rendered":"\n

Cystic\nFibrosis (CF) is the most common life-limiting autosomal recessive disorder in\nthe Caucasian population.<\/p>\n\n\n\n

Yourgene\u00a0CF-EU2v1\u00a0kit is used for diagnosis of quistic fibrosis through qualitative detection of the most common CFTR gene mutations found in european\u00a0population\u00a0in DNA extracted from whole blood (EDTA preserved) and dried bloodspot samples\u200b. \u00a0<\/p>\n\n\n\n

The assay\nidentifies 50 mutations in total and also\u00a0analyzes\nintron\u00a08\u00a0polyT\u00a0tract with accurate\u00a0measurement of the\nadjacent TG repeat.\u00a0Can distinguish between individuals who are\nheterozygous and homozygous for the all mutations and variants with the\nexception of S549R(T>G).<\/p>\n\n\n\n

For maximum coverage in the diagnosis of cystic Fibrosis, Yourgene CF-EU2 kit can be combined with the\u00a0Iberian Panel \u00a0kit<\/a> (12 additional mutations).<\/p>\n\n\n\n

CFTR gene\nmutations have also been associated with male infertility problems such as\nCongenital Unilateral Absence of the Vas Deferens (CUAVD) and Congenital\nBilateral Absence of the Vas Deferens (CBAVD), so Elucigene CF-EU2 kit also\nprovides a useful screening tool for these diseases. (More kits for diagnostic\nof male infertility,\u00a0here<\/a>)<\/p>\n\n\n\n

SPECIFICATIONS<\/strong><\/p>\n\n\n\n

Due to the\nnature of the design of the CF-EU2v1 kit the presence of insertions or\ndeletions between two opposing primers will result in size changes to all the\namplicon produced between these two primers.<\/p>\n\n\n\n

Therefore,\nin addition to the 50 mutations detected by the CF-EU2v1 kit, any insertions\nand deletions within the amplified target sequences can be detected by the\nchange in expected amplicon size in the wild type (B) mix.<\/p>\n\n\n\n