{"id":8022,"date":"2024-04-04T13:33:05","date_gmt":"2024-04-04T13:33:05","guid":{"rendered":"https:\/\/www.dlongwood.com\/dr-pcr-bcr-abl1-major-is-detection-kit-2\/"},"modified":"2025-05-22T08:37:14","modified_gmt":"2025-05-22T08:37:14","slug":"dr-pcr-bcr-abl1-major-is-detection-kit","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/dr-pcr-bcr-abl1-major-is-detection-kit\/","title":{"rendered":"Dr. PCR BCR-ABL1 Major IS Detection Kit"},"content":{"rendered":"\n<p>Dr. PCR\u2122 BCR-ABL1 Major IS Detection Kit is an in vitro diagnostic solution designed for monitoring patients with Chronic Myeloid Leukemia (CML). The kit is designed for the quantification of BCR-ABL1 (e13a2 and e14a2) and ABL1 transcripts from RNA extracted from whole blood.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen1-1.png\" alt=\"\" class=\"wp-image-18530\" title=\"\"><\/figure><\/div>\n\n\n\n<p>This is a digital PCR technology that stands out for its <strong>simplicity, speed, and degree of automation, including reverse transcription and amplification<\/strong> in a single step within the cartridge, and eliminating the need for calibration curves and replicates. All this reduces manual labor time to a minimum (10-15 min).<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen2.png\" alt=\"\" class=\"wp-image-18532\" title=\"\"><\/figure><\/div>\n\n\n\n<p>The dedicated digital PCR equipment features a simple interface and automatically calculates the <strong>result in %IS and molecular response (MR)<\/strong> in addition to reporting the <strong>absolute number of copies<\/strong> of both targets (BCR-ABL1 and ABL1). Two different devices are available, both desktop and compact in size:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>LOAA OnPoint: suitable for small sample numbers (works with 1 sample at a time)<\/li><li>LOAA-M: suitable for larger numbers of samples and adaptable. It is a modular equipment that allows processing from 1 to 16 samples in parallel (4 per module) with continuous loading.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-gallery aligncenter columns-3 is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\"><ul class=\"blocks-gallery-grid\"><li class=\"blocks-gallery-item\"><figure><a href=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen3.png\"><img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen3.png\" alt=\"\" data-id=\"18534\" data-full-url=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen3.png\" data-link=\"https:\/\/www.dlongwood.com\/?attachment_id=18534\" class=\"wp-image-18534\" title=\"\"><\/a><\/figure><\/li><li class=\"blocks-gallery-item\"><figure><a href=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen4.png\"><img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen4.png\" alt=\"\" data-id=\"18536\" data-full-url=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen4.png\" data-link=\"https:\/\/www.dlongwood.com\/?attachment_id=18536\" class=\"wp-image-18536\" title=\"\"><\/a><\/figure><\/li><li class=\"blocks-gallery-item\"><figure><a href=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen5.png\"><img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen5.png\" alt=\"\" data-id=\"18538\" data-full-url=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen5.png\" data-link=\"https:\/\/www.dlongwood.com\/?attachment_id=18538\" class=\"wp-image-18538\" title=\"\"><\/a><\/figure><\/li><\/ul><\/figure>\n\n\n\n<p>The performance of this solution is excellent, with high sensitivity and precision thanks to the real-time digital PCR technology developed by Optolane. With this approach, a final time reading of each partition is obtained, as well as a real-time reading of it, which allows the elimination of false positives by increasing the precision in targets that are found in low quantities.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen6.png\" alt=\"\" class=\"wp-image-18540\" title=\"\"><\/figure><\/div>\n\n\n\n<p><strong>Key aspects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Automated, fast, and simple solution: 1.5 h &#8211; 10 min of manual labor <\/li><li>Starting sample: RNA extracted from peripheral blood (10 ul, 60-150 ng\/ul) <\/li><li>Includes reverse transcription and dPCR in one step <\/li><li>Automatic calculation of MR, %IS, absolute number of copies <\/li><li>High sensitivity and precision &#8211; LoD: MR 4.6 (0.0025% IS) \/ Measurement range: 50-0.0025 %IS <\/li><li>CE-IVD marking \u00e0 IVDR in progress<\/li><\/ul>\n\n\n\n<p><strong><strong>Components of the kit:<\/strong><\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen9.png\" alt=\"\" class=\"wp-image-18542\" title=\"\"><\/figure><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.dlongwood.com\/wp-content\/uploads\/2024\/04\/Imagen10.png\" alt=\"\" class=\"wp-image-18544\" title=\"\"><\/figure><\/div>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. PCR\u2122 BCR-ABL1 Major IS Detection Kit is an in vitro diagnostic solution designed for monitoring patients with Chronic Myeloid Leukemia (CML). The kit is designed for the quantification of BCR-ABL1 (e13a2 and e14a2) and ABL1 transcripts from RNA extracted from whole blood. This is a digital PCR technology that stands out for its simplicity, [&hellip;]<\/p>\n","protected":false},"featured_media":10000,"template":"","tecnologias":[123],"marcas":[250],"familias":[337,340,336],"class_list":["post-8022","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-digital-pcr","marcas-optolane-technologies-en","familias-minimal-residual-disease","familias-myeloid-line","familias-oncohematology"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/8022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":0,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/8022\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/10000"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=8022"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=8022"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=8022"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=8022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}