{"id":8522,"date":"2023-02-21T16:33:01","date_gmt":"2023-02-21T16:33:01","guid":{"rendered":"https:\/\/www.dlongwood.com\/genvinset-mthfr-a1298c\/"},"modified":"2025-05-22T10:22:55","modified_gmt":"2025-05-22T10:22:55","slug":"genvinset-mthfr-a1298c","status":"publish","type":"productos","link":"https:\/\/www.dlongwood.com\/en\/product-catalog\/genvinset-mthfr-a1298c\/","title":{"rendered":"Genvinset\u00ae MTHFR A1298C"},"content":{"rendered":"\n

Kit for detecting the A1298C polymorphism of the\u00a0MTHFR<\/em>\u00a0gene by Real Time PCR using TaqMan\u00ae probes technology<\/p>\n\n\n\n

Information about the product<\/strong><\/p>\n\n\n\n

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Although MTHFR protein does not participate in the clotting cascade as other proteins such as FII and FV (and therefore belonging to the well-known group of coagulation factors), the involvement of MTHFR in the folate metabolic pathway may affect thrombophilia development, as well as increased cancer risk or Alzheimer\u2019s disease appearance.<\/p>\n\n\n\n

MTHFR<\/em>\u00a0gen can present different polymorphisms. The most common and studied variant is the MTHFR C677T polymorphism but, also, the MTHFR A1298C mutation has been studied. The frequency of both MTHFR polymorphisms differs among the different ethnicities.<\/p>\n\n\n\n

Intended Use<\/strong><\/p>\n\n\n\n

Genvinset\u00ae MTHFR A1298C is a semi-automated kit for the\u00a0in vitro<\/em>\u00a0qualitative detection of the A1298C polymorphism (NCBI dbSNP rs1801131; NM_001330358.2:c.1409A>C) in the Methylene tetrahydrofolate reductase (MTHFR<\/em>) gene (OMIM: 607093) associated with thrombophilia risk in genomic DNA extracted from whole blood using Real Time PCR technology with specific TaqMan\u00ae probes.<\/p>\n\n\n\n

Patients who can benefit from this determination are those referred by a specialist. The results of this test should not be the only ones on which the therapeutic decision is based and should be used as an aid in the diagnosis together with results of other markers of the disease.<\/p>\n\n\n\n

The intended user of the kit is technical personnel trained to carry out the protocol and the interpretation of results described in the instructions for use.<\/p>\n\n\n\n

Genvinset\u00ae MTHFR A1298C is a kit for the in vitro qualitative detection of the A1298C polymorphism (NCBI dbSNP rs1801131; NM_001330358.2:c.1409A>C) in the Methylene tetrahydrofolate reductase (MTHFR<\/em>) gene (OMIM: 607093) associated with thrombophilia risk in genomic DNA extracted from whole blood using Real Time PCR technology with specific TaqMan\u00ae probes.<\/p>\n\n\n\n

Patients who can benefit from this determination are those referred by a specialist. The results of this test should not be the only ones on which the therapeutic decision is based and should be used as an aid in the diagnosis together with results of other markers of the disease.<\/p>\n\n\n\n

The intended user of the kit is technical personnel trained to carry out the protocol and the interpretation of results described in this document.<\/p>\n\n\n\n

Workflow<\/strong><\/p>\n\n\n\n

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Results<\/strong><\/p>\n\n\n\n

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Limitations<\/strong><\/p>\n\n\n\n

  • Mutations or polymorphisms at annealing primer\/probe sites are possible and may result in the lack of allele definition. Other technologies could be necessary to resolve the typing.<\/li>
  • Data and result interpretation should be revised by qualified personnel.<\/li>
  • This product is an auxiliary tool for the diagnosis of patients with suspected thrombophilia. Use these results in conjunction with clinical data and results of other tests performed on the patient.<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"

    Kit for detecting the A1298C polymorphism of the\u00a0MTHFR\u00a0gene by Real Time PCR using TaqMan\u00ae probes technology Information about the product Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Although MTHFR protein does not participate in the clotting cascade as other proteins such as FII and FV (and therefore belonging to the well-known group […]<\/p>\n","protected":false},"featured_media":8532,"template":"","tecnologias":[275],"marcas":[225],"familias":[307,283,369,296],"class_list":["post-8522","productos","type-productos","status-publish","has-post-thumbnail","hentry","tecnologias-rt-pcr-en","marcas-blackhills-diagnostic-resources-en","familias-hematology-and-blood-bank","familias-molecular-genetics","familias-thrombophilias-hematology","familias-thrombophilias"],"_links":{"self":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/8522","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos"}],"about":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/types\/productos"}],"version-history":[{"count":0,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/productos\/8522\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media\/8532"}],"wp:attachment":[{"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/media?parent=8522"}],"wp:term":[{"taxonomy":"tecnologias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/tecnologias?post=8522"},{"taxonomy":"marcas","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/marcas?post=8522"},{"taxonomy":"familias","embeddable":true,"href":"https:\/\/www.dlongwood.com\/en\/wp-json\/wp\/v2\/familias?post=8522"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}