Significance and detection of chimerism after hematopoietic stem cell transplantation – GenDx

October 28, 12.00-12.30 pm | Online

Dr. Katarina Štingl Janković
University Hospital Centre Zagreb

In this webinar, Dr. Katarina Štingl Janković, University Hospital Centre Zagreb will present the basic concepts about the chimerism analysis procedure, discuss the relevance of the test results in the malignant and non-malignant disease scenarios and briefly review the current methodologies used in this field.

The outcome of the hematopoietic stem cell transplantation (HSCT) depends heavily on timely and precise interventions in the early post-transplantation period, such as donor lymphocyte infusions and changes in the immunosuppresion administration. A decision about the necessity of these interventions can be made only if a very close monitoring of the engraftment is performed.

Chimerism analysis is a powerful tool for achieving this purpose and has become a routine procedure for HSCT patient follow-up, in some cases becoming even a substitute for the minimal residual disease detection.