Operating Principle: The Devyser CFTR NGS kit redefines the genetic diagnosis of cystic fibrosis by offering a comprehensive and precise solution, validated for clinical use. With a unique single-tube library preparation approach, this kit optimizes the CFTR gene analysis process, significantly reducing hands-on time and contamination risk while improving diagnostic accuracy.

Clinical Applications

Advances in NGS techniques allow laboratories to perform a comprehensive diagnosis by analyzing the entire CFTR gene, covering known and novel variants. The integrated analysis software, along with databases such as CFTR2, ensures that variants are classified with high reliability.

Benefits

High efficiency and optimal performance: A single tube per sample minimizes the risk of pre-analytical errors and contamination. Ease of use: <45 minutes of hands-on time and a total turnaround time of less than 5 hours, accelerating diagnostic turnaround times. Broad coverage including:
All exonic regions of the gene + a minimum of 20 bp at the 5′ end and 10 bp at the 3′ end of the exon/intron junctions. Promoter region. Clinically relevant deep intronic variants.
Complete solution: Allows the analysis of SNVs and indels, as well as CNVs and identification of specific variants such as poly-T and TG repeats. Adaptability: Integration with validated analysis software increases flexibility for laboratories with different needs. Compatible with DNA samples extracted from peripheral blood and dried blood spots.
Devyser CFTR for NGS

Technology Used

Multiplex PCR technology with targeted enrichment and subsequent library preparation for NGS workflows. The indices added to the samples come pre-dispensed in strip or plate format, minimizing the risk of contamination. Furthermore, the process includes a post-pooling library cleanup for all samples. The entire workflow is CE-IVD validated and supported by validated software solutions, including CNV analysis, enabling you to obtain precise and reliable results.

Intended Audience/User

Ideal for genetics and molecular biology laboratories requiring comprehensive and reliable analysis of the CFTR gene, especially in newborn screening programs, prenatal testing, and genetic counseling.

Key Features

Comprehensive coverage of the CFTR gene, including deep intronic variants and the promoter region.
Direct detection of CNVs and identification of poly-T variants and TG repeats.
Standardized and validated CE-IVD workflow.
Less than 45 minutes of hands-on time.
Minimal risk of sample mix-ups or contamination.
Compatible with validated bioinformatics analysis software.

Ordering Information

CE-IVD Devyser CFTR Kits
8-A101-8 8 tests
8-A101-24 24 tests
8-A101-96 96 tests
RUO Devyser CFTR Kits
8-A103-8 8 tests
8-A103-24 24 tests
8-A103-96 96 tests
Accessories
8-A200 Devyser Index Plate A
8-A204 Devyser Library Clean

Area:

Cystic fibrosis, Molecular Genetics, Targeted study of specific pathologies

Brand:

Consult our experts

Google reCaptcha: Invalid site key.

Related products

Hedera Profiling RNA Test Panel

In‑house targeted enrichment NGS panel for RNA profiling from tissue samples (FFPE). It analyzes 43 genes using a splice‑aware probe design anchored to exon boundaries. Detects fusions in a partner-agnostic manner, complex splicing variants, and gene expression profiles in a single workflow. Detailed Description Principle of operation End‑to‑end solution based on hybrid capture enrichment chemistry…
HederaDx
Next Generation Sequencing (NGS)

Hedera Profiling ctDNA 3

In‑house targeted enrichment NGS panel exclusively for liquid biopsy (cfDNA). It analyzes 43 genes with ESCAT I and II clinical evidence. Includes library preparation through an optimized workflow (DNA‑only) for plasma samples. Detects SNVs, Indels, CNVs, fusions and 36 microsatellite instability (MSI) markers. Detailed Description Principle of operation End‑to‑end solution based on hybridisation and capture…
HederaDx
Next Generation Sequencing (NGS)

Hedera Profiling 1 FFPE Test Panel (HP1)

In‑house targeted enrichment NGS panel for pan‑cancer solid tumor profiling. It analyzes 115 genes (79 with complete CDS) with ESCAT I, II and III clinical evidence. Includes library preparation through a flexible workflow that allows processing FFPE and cfDNA samples together or separately. Detects SNVs, Indels, CNVs, fusions, structural variants and MSI. Detailed Description PRINCIPLE…
HederaDx
Next Generation Sequencing (NGS)

Sepsis Pathogenic Microorganism Detection Kit (Digital PCR)

In vitro diagnostic kit based on droplet digital PCR (dPCR) for the detection of pathogenic microorganisms associated with sepsis from DNA extracted from clinical samples. The kit allows identification and quantification of pathogens without requiring blood culture, covering 21 frequent agents in bloodstream infections. Detailed Description Principle of operation The Sepsis Pathogenic Microorganism Detection Kit…
RainSure
Digital PCR