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KIR Ready Gene

Las células natural killer (células NK) son células efectoras importantes del sistema de inmune innato. En las primeras fases de la respuesta, estas células participan en la eliminación de células infectadas o malignas. Los receptores KIR regulan esta actividad en conjunto con las moléculas HLA, uniéndose a las células diana, y las destruyen en función de si la señal es activadora o inhibidora. Por tanto, las combinaciones de variantes de HLA de clase I y KIR se correlacionan no sólo con el resultado de los trasplantes, sino también con la autoinmunidad (por ejemplo artritis reumatoide, psoriasis), infecciones virales y complicaciones durante el embarazo.

El kit KIR Ready Gene sirve para el tipaje de los genes de los receptores KIR mediante PCR y análisis en gel de agarosa.

Area:

Blood group genotyping, Hematology, Immunology, Medium-low resolution HLA typing

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