Devyser BRCA PALB2 NGS is a fast and robust NGS solution designed for the detection of genetic variants in the BRCA1, BRCA2, and PALB2 genes. It offers comprehensive and uniform coverage of all coding exons and exon/intron junctions of both genes. In addition, it includes the detection of single nucleotide variants (SNVs), insertions/deletions (Indels), and copy number variations (CNVs), in both germline and somatic contexts.

Key Features

Comprehensive variant detection: Identifies relevant genetic variants in the BRCA1, BRCA2, and PALB2 genes, including CNVs.
Fast workflow: optimized for rapid results with same-day library preparation and less than 45 minutes of hands-on time.
A single workflow is easily and effectively applied to two applications: germline and somatic analysis.
Dedicated software: Provides automated, user-friendly analysis, with options for batch export and efficient variant analysis without the need for bioinformatics expertise.
Devyser BRCA PALB2 NGS Workflow

Intended Audience / User

Ideal for laboratories that need to comprehensively analyze the BRCA1, BRCA2, and PALB2 genes in a streamlined workflow. The targeted sequencing approach and uniform coverage of target regions maximize the retrieval of relevant data in every sequencing run.

Benefits

Streamlined workflow: easy to implement and suitable for laboratories with varying sample volume needs. Ready-to-use reagents, ensuring a reproducible process and reducing the risk of sample mix-ups or contamination. Compatible with germline and somatic analysis under the same workflow. Intuitive software: facilitates the interpretation of obtained data, reducing the need for bioinformatics intervention.

Additional Considerations

Starting material: Human genomic DNA extracted from whole blood or FFPE tissue. In FFPE samples, it is necessary to previously evaluate concentration and integrity, as initial sample quality can compromise the assay results.

Ordering Information

Devyser BRCA PALB2 Kits
8-A408-8 8 tests
8-A408-24 24 tests
8-A408-96 96 tests
Purification, Sequencing, and Analysis
Purification Devyser Library Clean (8-A204) for library purification.
Sequencing Sequencing on Illumina MiSeq.
Analysis Analysis in Amplicon Suite with Devyser BRCA PALB2 pipeline.

Area:

Hereditary cancer, Molecular Genetics, Solid tumor, Targeted study of specific pathologies

Brand:

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