Devyser BRCA PALB2 NGS is a fast and robust NGS solution designed for the detection of genetic variants in the BRCA1, BRCA2, and PALB2 genes. It offers comprehensive and uniform coverage of all coding exons and exon/intron junctions of both genes. In addition, it includes the detection of single nucleotide variants (SNVs), insertions/deletions (Indels), and copy number variations (CNVs), in both germline and somatic contexts.
Key Features
Comprehensive variant detection: Identifies relevant genetic variants in the BRCA1, BRCA2, and PALB2 genes, including CNVs.
Fast workflow: optimized for rapid results with same-day library preparation and less than 45 minutes of hands-on time.
A single workflow is easily and effectively applied to two applications: germline and somatic analysis.
Dedicated software: Provides automated, user-friendly analysis, with options for batch export and efficient variant analysis without the need for bioinformatics expertise.
Intended Audience / User
Ideal for laboratories that need to comprehensively analyze the BRCA1, BRCA2, and PALB2 genes in a streamlined workflow. The targeted sequencing approach and uniform coverage of target regions maximize the retrieval of relevant data in every sequencing run.
Benefits
Streamlined workflow: easy to implement and suitable for laboratories with varying sample volume needs.
Ready-to-use reagents, ensuring a reproducible process and reducing the risk of sample mix-ups or contamination.
Compatible with germline and somatic analysis under the same workflow.
Intuitive software: facilitates the interpretation of obtained data, reducing the need for bioinformatics intervention.
Additional Considerations
Starting material: Human genomic DNA extracted from whole blood or FFPE tissue.
In FFPE samples, it is necessary to previously evaluate concentration and integrity, as initial sample quality can compromise the assay results.
Ordering Information
Devyser BRCA PALB2 Kits
| 8-A408-8 | 8 tests |
| 8-A408-24 | 24 tests |
| 8-A408-96 | 96 tests |
Purification, Sequencing, and Analysis
| Purification | Devyser Library Clean (8-A204) for library purification. |
| Sequencing | Sequencing on Illumina MiSeq. |
| Analysis | Analysis in Amplicon Suite with Devyser BRCA PALB2 pipeline. |
