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Devyser HBOC NGS is a fast and robust NGS solution aimed at the detection of germline variants in 12 genes associated with an increased risk of hereditary breast and ovarian cancer: ATM, BARD1, BRIP1, CDH1, CHEK2, NBN, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53. It offers comprehensive and uniform coverage of all coding exons and exon/intron junctions of both genes. In addition, it includes the detection of single nucleotide variants (SNVs), insertions/deletions (Indels), and copy number variations (CNVs).

Key Features

Comprehensive detection of genetic variants in 12 relevant genes in hereditary breast and ovarian cancer.
Fast workflow: optimized for rapid results with same-day library preparation and less than 45 minutes of hands-on time.
Identification of germline and somatic variants, including CNV detection and 12 internal identity markers.
Dedicated software: Provides automated, user-friendly analysis, with options for batch export and efficient variant analysis without the need for bioinformatics expertise.

Clinical Applications

The panel is intended to identify variants in 12 genes implicated in the risk of developing breast and/or ovarian cancer: ATM, BARD1, BRIP1, CDH1, CHEK2, NBN, PALB2, PTEN, RAD51C, RAD51D, STK11, and TP53.

Intended Audience / User

Ideal for laboratories focused on the targeted analysis of genes related to breast and/or ovarian cancer predisposition.

Benefits

Streamlined workflow: easy to implement and suitable for laboratories with varying sample volume needs. Ready-to-use reagents, ensuring a reproducible process, and 12 sample identity markers are included to help minimize the risk of mix-ups associated with the use of two amplification mixes per sample. Intuitive software: facilitates the interpretation of obtained data, reducing the need for bioinformatics intervention.

Ordering Information

CE-IVD Marked
8-A111-24 24 tests.
8-A111-48 48 tests.
RUO Marked
8-A111-24-RUO 24 tests.
8-A111-48-RUO 48 tests.
Additional Reagents
8-A204 Devyser Library Clean

Area:

Hereditary cancer, Molecular Genetics, Targeted study of specific pathologies

Brand:

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