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PGTA-ChromInst® (Preimplantation Genetic Testing for Aneuploidies)

CatalogMolecular GeneticsPrenatal Diagnosis

PGT-A (Preimplantation Genetic Testing for Aneuploidies) solution, that combines WGA and library preparation for NGS (MALBAC® technology).

PGTA-ChromInst® (Preimplantation Genetic Testing for Aneuploidies) is a PGT-A solution. It combines in a single step WGA (Whole Genome Amplification) and library preparation for NGS (Next Generation Sequencing), (MALBAC® technology), guaranteeing a uniform and efficient amplification of DNA (MALBAC® technology).

MALBAC® technology 

WGA methods are prone to introduce amplification bias, as they amplify some regions better than others. However, MALBAC® (Multiple Annealing and Looping Based Amplification Cycles) technology results in amplification products that have complementary ends capable of forming loops of DNA, which enhances the quasi-linearity of amplification. In this way, much better amplification uniformity is achieved than with the other WGA methods described to date.

High genome coverage and amplification of >90% of loci is achieved with this technology. In addition, the ADO (Allele Drop Out) rate is <10%. 

Features: 

  • Easy:  
    <1.5hrs hand-on work; WGA and Lib Prep are combined in one step. 
  • Safe:  
    Single tube/well reactions to avoid sample loss and contamination. 
  • Timesaving: 
    The whole process can be finished within 24 hours (9 hours if coupled with Illumina's MiniSeq or MiSeq sequencers, and the auto-analysis bioinformatics platform ChromGO™). 
  • Flexible: 
    Compatible with both Illumina (Miniseq and MiSeq included) and Ion Torrent sequencing platforms. 
  • Accurate: 
    Most advanced single cell WGA technique. 
  • Complete:  
    An entire solution, from sample preparation to report output.

ChromGO™ 

Simple data analysis solution, which allows you to quickly customize your data analysis reports on both online and local servers. 

Features:

  • Intuitive and simple interface. 
  • Versatile: data can be analyzed with different criteria (mosaicism, gender information...).
  • Detailed: details QC (Quality Control), including reads, GC content and CV (coefficient variation) presented in individual files.
  • Flexible: NGS data from different sequencing platforms can be processed.
  • 1M reads/sample for the detection of 10Mb deletions.

Who is it for? 

  • Women with advanced maternal age. 
  • Men with azoospermia. 
  • Patients with recurrent pregnancy losses. 
  • Patients with repeated implantation failures. 
  • Patients with chromosome structural abnormalities, such as reciprocal translocation and Robertsonian translocation. 

Presentations

Product nameNºSize
PGTA-ChromInst®YK-PGT-A-4848 reactions

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    Product families

    • Molecular Genetics
      • Prenatal Diagnosis
      • Triplet Expansion
      • Pharmacogenomics
      • Cystic Fibrosis
      • Other – Genetics
      • Genetic Panels
      • Reproduction
    • Hematology and blood bank
      • Platelet Antibody Testing
      • Cryopreservation
      • Blood Group Genotyping (RBC)
      • Other – Hematology
      • Thrombophilias and Hemochromatosis
    • Immunology and transplantation
      • Alloantibodies Detection
      • HLA-associated diseases
      • Immunosequencing
      • Other – Immunology
      • Chimerism
      • Immune response and biomarkers
      • HLA Typing
    • Microbiology
      • Fungus
      • NGS
      • Sepsis
      • Syndromic
    • Oncology
      • Oncohematology
      • Solid Tumor
    • Preanalytics
      • Sampling and Extraction
      • Blood collection
      • Sample transportation

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