Devyser FH

Next-generation sequencing kit for the comprehensive analysis of genes associated with familial hypercholesterolemia, including a polygenic risk score and a SNP panel for statin response.

Detailed Description

Operating Principle

The Devyser FH kit is an amplicon-based NGS library preparation solution with a single-tube protocol that enables targeted amplification and sample indexing within a streamlined workflow. All samples are pooled into a single tube prior to sequencing. Pre-dispensed indices in strips or plates ensure proper sample handling, minimizing errors.

Clinical Applications

The panel is designed to cover the analysis of all relevant genes for the genetic study of familial hypercholesterolemia and facilitates the identification of SNPs associated with statin response. It is highly useful for molecular laboratories or centers requiring a rapid and comprehensive approach to these pathologies.

Benefits

Optimized coverage: panel specifically designed to comprehensively cover clinically relevant regions for the study of familial hypercholesterolemia. Complete solution with support across all protocol steps and through a single vendor. Uniformity: consistent and uniform sequencing performance across libraries. Scalability across multiple Illumina sequencing systems.

Intended Audience/User

Laboratories performing genetic testing for familial hypercholesterolemia that require a fast, easy, and complete workflow with included software for accurate diagnosis of these pathologies.

Key Features

Comprehensive coverage of LDLR, APOB, PCSK9, APOE, STAP1, and LDLRAP1 genes (including CNV detection), and SNPs associated with polygenic risk and statin response.

Less than 45 minutes of hands-on time.

Minimal risk of sample mix-up or contamination thanks to the single-tube design.

Integrated sex detection to minimize sample identification errors.

Simple, standardized, and efficient workflow.

Dedicated software solution available with standardized reporting, facilitating result interpretation.

Ordering Information

RUO Devyser FH Kits

8-A109-24-RUO	24 tests
8-A109-48-RUO	48 tests

Accessories

8-A204	Devyser Library Clean
8-A200	Devyser Index Plate A

Area:

Familial hypercholesterolemia, Hereditary and/or Rare Diseases, Molecular Genetics

Technology:

Next Generation Sequencing (NGS)

Brand:

Devyser

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